Author(s):
Mahesh Hari Kolhe, Ritu Mehra Gilhotra, Govind Sarangdhar Asane
Email(s):
kolhe.mh@gmail.com
DOI:
10.52711/0974-360X.2021.00393 
Address:
Mahesh Hari Kolhe1,2*, Ritu Mehra Gilhotra3, Govind Sarangdhar Asane4
1Research Scholar, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Mahal, Jagatpura, Jaipur, Rajasthan, India- 302017.
2Department of Pharmaceutics, Pravara Rural College of Pharmacy, Pravaranagar, Ahmednagar, Maharashtra, India – 413736.
3Principal and Dean, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Mahal, Jagatpura, Jaipur, Rajasthan, India- 302017.
4St. John Institute of Pharmacy and Research, Palghar, Maharashtra, India- 401404.
*Corresponding Author
Published In:
Volume - 14,
Issue - 4,
Year - 2021
ABSTRACT:
Atenolol is beta blocker absorbed through GIT use for heart diseases. Single tablets, floating tablets and sustained released formulations studied are insufficient to produce effective dose to enhance bioavailability and effectiveness. Our study is focused on development of capsule dosage form containing immediate release (IR) and floating extended release (ER) tablets for monitoring release of atenolol in single dosage form. Two different tablets for IR and ER were prepared in three different combinations (Batch). Pre-formulation and post formulation parameters found to be within acceptable limits of formulation. Release behavior of individual tablets and capsule containing two tablets were studied. Among the batches, capsules containing smaller amount of atenolol in IR and large amount of Atenolol in ER (batch II) showed impressive drug release pattern. This formulation was stable even after a month and achieved optimum release behavior of immediate release and sustained release. This study could be used for effective treatment for different heart complications and reduce toxicity due to high plasma concentration in increased dose frequency.
Cite this article:
Mahesh Hari Kolhe, Ritu Mehra Gilhotra, Govind Sarangdhar Asane. Development of Capsule containing Immediate Release Tablet and Extended Release Floating Tablet for Monitoring Release of Atenolol. Research Journal of Pharmacy and Technology. 2021; 14(4):2216-0. doi: 10.52711/0974-360X.2021.00393
Cite(Electronic):
Mahesh Hari Kolhe, Ritu Mehra Gilhotra, Govind Sarangdhar Asane. Development of Capsule containing Immediate Release Tablet and Extended Release Floating Tablet for Monitoring Release of Atenolol. Research Journal of Pharmacy and Technology. 2021; 14(4):2216-0. doi: 10.52711/0974-360X.2021.00393 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-4-69
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