Author(s):
Sonia Dhiman, Thakur Gurjeet Singh*, Shivangi Anand, Priyanka Yadav
Email(s):
gurjeetthakur@gmail.com
DOI:
10.52711/0974-360X.2021.00449 
Address:
Sonia Dhiman, Thakur Gurjeet Singh*, Shivangi Anand, Priyanka Yadav
Chitkara College of Pharmacy, Chitkara University, Punjab, India.
*Corresponding Author
Published In:
Volume - 14,
Issue - 5,
Year - 2021
ABSTRACT:
Zidovudine is one of the chief nucleoside analogue and reverse inhibitor licensed for HIV infection which is placed along with a group of retroviruses. The present research study on Zidovudine solid dosage form surveyed the feasibility utilizing solid lipid nanoparticles (SLNs) for controlled drug delivery of zidovudine embracing glyceryl behenate as lipidic material, tween 80 as a stabilizer and blend of sodium chelate with poloxamer as surfactant. The SLNs were prepared utilizing high pressure homogenization followed by ultrasonication method. The prepared SLNs were characterized by particle size analysis, polydispersity index, zeta potential, DSC, TEM, IR spectroscopy, and X-ray diffractometry. Narrow size distribution of the particles was marked having polydispersity index values under 0.8. The high zeta potential of the different SLN formulations additionally showed their physical stability. Differential scanning calorimetry and powder X-ray diffraction showed decline in crystallinity of drug in the nanoparticle formulation. In vitro release study showed sustained release for up to 12 hours in the SLN formulations prepared. The current study results revealed that zidovudine SLN formulation prepared by high pressure homogenization followed by ultrasonication is a suitable method for controlled drug delivery system.
Cite this article:
Sonia Dhiman, Thakur Gurjeet Singh*, Shivangi Anand, Priyanka Yadav. Formulation and Evaluation of Solid Lipid Nanoparticles for controlled delivery of Zidovudine. Research Journal of Pharmacy and Technology. 2021; 14(5):2548-6. doi: 10.52711/0974-360X.2021.00449
Cite(Electronic):
Sonia Dhiman, Thakur Gurjeet Singh*, Shivangi Anand, Priyanka Yadav. Formulation and Evaluation of Solid Lipid Nanoparticles for controlled delivery of Zidovudine. Research Journal of Pharmacy and Technology. 2021; 14(5):2548-6. doi: 10.52711/0974-360X.2021.00449 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-5-33
REFERENCES:
1. Kumar V, Verma AK, Yadav DC. A Review on Solid Lipid Nano Particles (SLNS). Research Journal of Pharmacy and Technology. 2019;12(11): 5605-13.
2. Soumya RS, Sherin S, Raghu KG, Abraham A. Allicin functionalized locust bean gum nanoparticles for improved therapeutic efficacy: An in silico, in vitro and in vivo approach. International journal of biological macromolecules. 2017; 109: 740-47.
3. Rajpurohit VS, Rakha P, Goyal S, Durejab H, Arorac G, Nagpal M. Formulation and characterization of solid dispersions of glimepiride through factorial design. Iranian Journal of Pharmaceutical Sciences. 2011; 7(1): 7-16.
4. Choudhary A, Aggarwal G, Zakir F, Kumar V. Mini review: journey of solid dispersion technique from bench to scale. International research journal of pharmacy. 2011; 2(8): 46-51.
5. Brahmankar DM, Jaiswal SB. Biopharmaceutical and pharmacokinetics A treatise. 2nd Edition, Vallabh Prakashan. 2009.
6. Khan W, Ansari VA, Hussain Z, Siddique NF. Nanoemulsion: A Droplet Nanocarrier System for Enhancing Bioavailability of Poorly Water Soluble Drugs. Research Journal of Pharmacy and Technology. 2018;11(11): 5191-6.
7. Verma S, Rawat A, Kaul M, Saini S. Solid dispersion: a strategy for solubility enhancement. International journal of pharmacy and technology. 2011; 3(2): 1062-1099.
8. Kalia Anupama, Poddar Mayur. Solid dispersion: An approach towards enhancing dissolution rate. Journal of Pharmacy and Pharmaceutical Sciences. 2011; 3(4): 9-19.
9. Sharada CH, Channabasavaraj KP, Srikanth A, Babu JG, Panditi VR, Reddy YB. Validated RP-HPLC Method for the Quantitative Estimation of Zidovudine in Bulk and Pharmaceutical Dosage Forms. Research Journal of Pharmacy and Technology. 2010;3(3): 773-5.
10. Gupta PK, Pandit JK, Narain PJ, Gupta RN, Gupta SK. Preparation of Diclofenac Diethylamine Nanoemulsions by Ultrasonication-Stability and Process Parameter Evaluation under Various Conditions. Research Journal of Pharmaceutical Dosage Forms and Technology. 2011;3(6): 285-93.
11. Sawicki E, Schellens JH, Beijnen JH, Nuijen B. Inventory of oral anticancer agents: Pharmaceutical formulation aspects with focus on the solid dispersion technique. Cancer treatment reviews. 2016; (50): 247-63.
12. Narang A, Shrivastava A. Melt extrusion solid dispersion technique. Drug Development and Industrial Pharmacy. 2002; 26(8): 111-5.
13. Chokshi R, Zia H. Hot-melt extrusion technique: a review. Iranian Journal of Pharmaceutical Research. 2010; (20): 3-16.
14. Perissutti B, Newton JM, Podczeck F, Rubessa F. Preparation of extruded carbamazepine and PEG 4000 as a potential rapid release dosage form. European journal of pharmaceutics and biopharmaceutics. 2002; 53(1): 125-32.
15. Tsinontides SC, Rajniak P, Pham D, Hunke WA, Placek J, Reynolds SD. Freeze drying—principles and practice for successful scale-up to manufacturing. International journal of pharmaceutics. 2004; 280(1-2): 1-6.
16. Nadig S, Jacob JT. A stability indicating RP-HPLC assay method for simultaneous estimation of abacavir, Lamivudine, Nevirapine and Zidovudine in pharmaceutical dosage form. Research Journal of Pharmacy and Technology. 2016;9(11): 1985-90.
17. Shanmugam S, Rajan SB, Ayyappan T, Sundaramoorthy K, Vetrichelvan T. Formulation and evaluation of sustained release matrix tablet of zidovudine using different polymers. Research Journal of Pharmaceutical Dosage Forms and Technology. 2011;3(1): 17-23.
18. Vinod R, Kumar PA, Yadav AS, Rao BS, Kulkarni SV. Formulation and Evaluation of Controlled Release Microspheres of Zidovudine. Research Journal of Pharmaceutical Dosage Forms and Technology. 2010;2(1): 96-9.
19. Bala R, Madaan R, Vibhu A, Arora S. Isolation and Evaluation of Hibiscus Rosa-Sinensis leaf Mucilage as Super disintegrant, European Journal of Pharmaceutical and Medical Research. 2016; 3(8): 434-440.
20. Westesen K. Novel lipid-based colloidal dispersions as potential drug administration systems-expectations and reality. Coll Polym Sci. 2010; 278: 609-618.
21. Puncochova K, Heng JY, Beranek J, Stepanek F. Investigation of drug–polymer interaction in solid dispersions by vapour sorption methods. International journal of pharmaceutics. 2014; 469(1): 159-67.
22. Chang D, Jankunee M, Barauskas J, Tiberg F, Nylander T. Adsorption of lipid liquid crystalline nanoparticles on cationic, hydrophilic, and hydrophobic surfaces. ACS Applied Materials and Interfaces.2012; 2643-2651.
23. Neves JD, Amiji M, Bahia MF, Sarmento B. Nanotechnology-based systems for the treatment and prevention of HIV/AIDS. Advanced Drug Delivery Reviews vol.62. 2010; 458-477.
24. Kaerger JS. Processing of spherical crystalline particles via a novel solution atomisation and crystallization by sonication (SAXS) technique. Pharmaceutical Research. 2004; 372-381.
25. Shukla D, Chkraborty S, Singh S, Mishra B. Lipid based oral multiparticulate formulations advantages, technological advances and industrial applications. Expert Opinion on Drug Delivery, vol.8. 2011; 207-224.
26. Lohiya K. Overview on osmotically controlled drug delivery system. Research Journal of Pharmaceutical Dosage Forms and Technology. 2017;9(2): 67-70.
27. Gawai MN, Surwade K, Phadatare SD. Emphasis on Controlled Drug Delivery System-A Review. Research Journal of Pharmaceutical Dosage Forms and Technology. 2018;10(4): 215-9.
28. Bele MH, Derle DV. Analysis of patents pertaining to super disintegrants used in tablet manufacturing. Journal of Intellectual Property Rights. 2008; 18(1): 601-04.
29. Beneke CE, Viljoen AM, Hamman JH. Polymeric plant-derived excipients in drug delivery. Molecules. 2009; 14(7): 2602-20.
30. Jensen CE, Dos Santos RA, Denadai AM, Santos CF, Braga AN, Sinisterra RD. Pharmaceutical composition of valsartan: β-Cyclodextrin: physico–chemical characterization and anti-hypertensive evaluation. Molecules. 2010; 15(6): 4067-84.
31. Sunil KJ, Awasthi AM, Jain NK, Agarwal GP. Calcium silicate based microspheres of repaglinide for gastro retentive floating drug delivery: preparation and in vitro characterization. J. Controlled Release. 2005; 300-309.