Author(s): Sofi N Stiani, Anas Subarnas, Taofik Rusdiana


DOI: 10.52711/0974-360X.2021.00514   

Address: Sofi N Stiani1,2, Anas Subarnas3, Taofik Rusdiana1
1Department of Pharmaceutics and Pharmaceutical Technology, Padjadjaran University, Indonesia.
2Pharmacy Study Program, STIKes Salsabila, Serang Banten, Indonesia.
3Department of Pharmacology and Clinical Pharmacy, Padjadjaran University, Indonesia.
*Corresponding Author

Published In:   Volume - 14,      Issue - 6,     Year - 2021

Apigenin is a flavonoid belonging to a flavone subclass that is reported to have many benefits and less toxic than other flavonoid groups. Objective: The purpose of this study is to evaluate antinephrolithiasis activity of modified Hot Melt Extrusion (HME) apigenin formulas with Soluplus® and Kollidon® VA 64 polymers in rats. Method: In this study, rats were administered ethylene glycol 0.75% and ammonium chloride 2% as inducing agents for formation of kidney stone. Rats in each group were given the formulas of apigenin without HME, or apigenin with HME soluplus® polymer and apigenin with HME Kollidon® VA 64 polymer every day for seven days. The concentration of calcium oxalate in the kidney and the urine was measured using the atomic absorption spectrophotometer (AAS). Urine volume and urine pH were also measured. Result: The results of this study indicated that the apigenin formulas with HME soluplus® polymers can shed kidney stones at a dose of 4.8mg/kg of body weight. Its effect was stronger than the apigenin formula with Kollidon®. Conclusion: The formula of Apigenin with HME Soluplus® polymers is better than that of Kollidon® polymers in removing kidney stones with the ratio of 10:90 at a dose of 4.8mg/kg.

Cite this article:
Sofi N Stiani, Anas Subarnas, Taofik Rusdiana. Anticalculi Activities of Apigenin Hot Melt Extrusion Results with Soluplus® and Kollidon® VA 64 Polymers on Wistar Rats. Research Journal of Pharmacy and Technology. 2021; 14(6):2931-6. doi: 10.52711/0974-360X.2021.00514

Sofi N Stiani, Anas Subarnas, Taofik Rusdiana. Anticalculi Activities of Apigenin Hot Melt Extrusion Results with Soluplus® and Kollidon® VA 64 Polymers on Wistar Rats. Research Journal of Pharmacy and Technology. 2021; 14(6):2931-6. doi: 10.52711/0974-360X.2021.00514   Available on:

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