Author(s):
Ashwin Kumar Saxena, Aditya Sharma, Navneet Verma
Email(s):
ashwinpharma04@gmail.com
DOI:
10.52711/0974-360X.2021.00602 
Address:
Ashwin Kumar Saxena1*, Aditya Sharma1, Navneet Verma2
1School of Pharmaceutical Sciences, IFTM University, Moradabad - 244102, Uttar Pradesh, India.
2Pharmacy Academy, IFTM University, Moradabad-244102, Uttar Pradesh, India.
*Corresponding Author
Published In:
Volume - 14,
Issue - 6,
Year - 2021
ABSTRACT:
Therapeutic research and development are increasingly focusing on delivery systems which enhance desirable objectives while minimizing side effects. Nowadays Dose dumping is a major problem of single particulate dosage forms. So there is a need of extended release Multi-particulate drug delivery systems. Microspheres are multiparticulate drug delivery systems which are prepared to obtain prolonged or controlled drug delivery to improve bioavailability, stability and to target the drug to specific site at a predetermined rate. In strict sense, they are spherical empty particles. The pharmaceutical scientists have achieved a great success in developing most therapeutic systems with suitable natural polymer. Multi-particulate drug delivery systems are developed to address the challenges of drug development. A well designed drug delivery system can overcome some of the problems of conventional therapy and enhance the therapeutic efficacy of given drug. It is the reliable means to deliver the drug to the target site specifically. They received much attention for prolonged release as well as targeting to treat various diseases. This Current review outlines the transient account of classification, methods of preparations, its application and also the evaluation characterization for their efficiency of microspheres.
Cite this article:
Ashwin Kumar Saxena, Aditya Sharma, Navneet Verma. Microspheres as Therapeutically effective Multiparticulate Drug Delivery System: A Systemic Review. Research Journal of Pharmacy and Technology. 2021; 14(6):3461-0. doi: 10.52711/0974-360X.2021.00602
Cite(Electronic):
Ashwin Kumar Saxena, Aditya Sharma, Navneet Verma. Microspheres as Therapeutically effective Multiparticulate Drug Delivery System: A Systemic Review. Research Journal of Pharmacy and Technology. 2021; 14(6):3461-0. doi: 10.52711/0974-360X.2021.00602 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-6-92
REFERENCES:
1. Kaur T, Bhawandeep G, Sandeep Kumar, Gupta GD. Mouth dissolving tablets: a novel approach to drug delivery. Int J Curr Pharm Res. 2011; 3(1):1-7.
2. Sirisha KVR, Vijayasri K, Devanna N, Kamalakar. Formulation and in vitro evaluation of Esomeprazole delayed release multiparticulate capsules. Int J Res Pharm Sci. 2013; 4(3):328-35.
3. Gandhi B, Baheti J. Multiparticulates drug delivery systems: a review. Indian J Pharm Chem Sci. 2013; 2(3):1620-1626.
4. Jamini M, Rawat S, A review on microsphere. Res j pharm boil chem sci. 2013; 4(1):1223-1233.
5. Patel NR, Patel DA, Bharadia PD, Pandya V, Modi D. Microsphere as a novel drug delivery. Int J Pharm Life Sci. 2011; 2(8): 992-997
6. Singh C, Purohit S, Singh M, Pandey BL. Design and evaluation of microspheres: A Review. JDDR. 2013; 2(2):18-27.
7. Prasanth VV, Moy AC, Mathew ST, Mathapan R. Microspheres An overview. Int J Res Pharm Biomed Sci. 2011; 2:332.
8. Prasad SG, Gupta VRM, Devanna N, Jayasurya K. Microspheres as drug delivery system: A review. JGTPS. 2014; 5(3):1961-1972.
9. Microsphere Selection Bangs laboratories inc, Tech Notes 201 A, 1-4 Available from URL: http://www.bangslabs.com/sites/def ault/files/bangs/do cs/pdf/201A.pdf
10. Save T, Venkatachalam P. Bioadhesive tablets of Nifedipine: Standardization of a novel buccoadhesive erodible carrier. Drug Delivery Ind pharm. 1994; 20(19):3005-3014.
11. Lopez CR, Portero A, Vila-Jato JC, Alonso MJ. Design and Evaluation of Chitosan/ Ethylcellulose mucoadhesive bilayered devices for buccal drug delivery. J Control Rel. 1998; 55:143-152.
12. Kunchu K, Veera RA. Albumin Microspheres: A Unique system as drug delivery carriers for non-steroidal anti-inflammatory drugs. International Journal of Pharmaceutical Sciences Review and Research. 2010; 5(2):10-17.
13. Available from URL: https://www.britannica.com/science/polymer
14. Patel NR, Patel DA, Bharadia PD, Pandya V, Modi D. Microsphere as a novel drug delivery. International Journal of Pharmacy & Life Sciences. 2011, 2(8):992-997.
15. Diane J. Burgress and Anthony J. Hickey , The University of North Carolina at Chapel Hill, Carolina, U.S.A, Encyclopedia of Pharmaceutical Technology, 2328-2337.
16. Li SP, Kowalski CR, Feld KM, Grim WM. Recent Advances in Microencapsulation Technology and Equipment. Drug Delivery Ind. Pharm. 1988; 14:353-376.
17. Available from URL: https://www.Pharmainfo. Net/Reviews/Bioadhesive microspheresreview.
18. Dutta P, Sruti J, Patra CN, Rao MEB. Floating microspheres: Recent trends in the development of gastrorententive floating drug delivery system. Int J Pharm Sci Nanotech. 2011; 4(1):1296-1306.
19. Mukund JY, Kantilal BR, Sudhakar RN. Floating microspheres: A review. Braz J Pharm Sci. 2012; 48(1):17-30.
20. Kawatra M, Jain U, Ramana J, Recent advances in floating microspheres as gastro-retentive drug delivery system: A review. IJRAPR. 2012; 2(3):5-23.
21. Singh C, Purohit S, Singh M, Pandey BL, Design and evaluation of microspheres: A Review. JDDR. 2013; 2(2):18-22.
22. Ramteke KH, Jadhav VB, Dhole SN. Microspheres: As carrieres used for novel drug delivery system. IOSRPHR. 2012; 2(4):44-48.
23. Saralidze K, Leo H, Menno KL, Knetsch W. Polymeric Microspheres for Medical Applications. Materials. 2010; 3:3357-3364.
24. Trivedi P, Verma AML, Garud N. Preparation and Characterization of Acclofenac Microspheres. Asian Journal of Pharmaceutics. 2008; 2(2):110-115.
25. Khar RK, Vyas SP. Targeted and Controlled Drug Delivery- Novel Carrier Systems., 1st edition, CBS Publications and Distributors, New Delhi, 2002.
26. Tiwari AK. Formulation and evaluation of floating microsphere h2 receptor blocker ranitidine hcl by ionic gelation method. International Journal of Pharmaceutical Science and Research. 2012; 3(8):118-123
27. Madhura V, Dhoka. Preparation of CefpodoximeProxetil -Polymeric Microspheres by the Emulsion Solvent Diffusion Method for taste masking. International Journal of Pharm Tech Research. 2011; 3(1):411-419.
28. Mazumder B. Preparation and in vitro evaluation of chlorpheniramine maleate loaded microspheres. International Journal of Pharm Tech Research. 2009; 1(3):905-913.
29. Patel B, Modi V, Patel K, Patel M. Preparation and evaluation of ethyl cellulose microspheres prepared by emulsification-solvent evaporation method. International Journal For Research In Management And Pharmacy. 2012; 1(1):83-91.
30. Bansal H, Kaur SP, Gupta AK. Microsphere: Methods of preparation and applications: A comparative study. Int J Pharm Sci Rev Res. 2011; 10(1):69-78.
31. Orienti I, Aiedeh KE, Bertasi GV, Zecchi V. Indomethacin loaded chitosan microspheres, correlation between the erosion process and release kinetics. Microencapsule. 1996; 13:463-472.
32. Thanoo BC, Sunny MC, Jayakrishnan A. Cross-linked chitosan microspheres: Preparation and evaluation as a matrix for the controlled release of pharmaceuticals. J Pharm Pharmacol. 1995; 44:283-286.
33. Deore BV, Mahajan HS, Deore UV. Development and characterization of sustained release microspheres by quasi emulsion solvent diffusion method. International Journal of Chem Tech Research. 2009; 1(3):634-642.
34. Alagusundaram M, Chetty CMS, Umashankari K, Badarinath AV, Lavanya C, Ramkanth S. Microspheres as a novel drug delivery sytem- A review. Int J Chem Tech Res. 2009; 1(3):526-534.
35. Mathew ST, Devi GS, Prasanth VV, Vinod B. NSAIDs as microspheres, The Internet Journal of Pharmacology. 2008; 6(1):67-73.
36. Mani S, Kumar NK. Preparation and evaluation of ethyl cellulose microspheres of ibuprofen for sustained drug delivery International Journal of Pharma Research and Development. 2010; 2(8):120-121.
37. Lohade AA, Singh DJ, Parmar JJ, Hegde DD, Menon MD, Soni PS, Samad A, Gaikwad RV, Albumin microspheres of Fluticasone propionate inclusion complexes for pulmonary delivery. IJPS. 2007; 707-709.
38. Felix K. Albumin as a drug carrier: Design of prodrugs, drug conjugates and nanoparticles. Journal of Controlled Release. 2008; 132:171-183
39. Thakkar H, Sharma RK, Mishra AK, Chuttani K, Murthy RR. Albumin Microspheres as Carriers for the Antiarthritic Drug Celecoxib. AAPS Pharm Sci Tech. 2005; 6(1):65-73.
40. Yadav A, Preparation and characterization of intra gastric gastro-retentive delivery system of diltiazem hydrochloride. Journal of Drug Delivery Research. 2011; 482-485
41. Rathod UC. Statistical Evaluation and Optimization of Influence of Stirring Speed and Polymer Concentration on Hollow Microspheres of Diltiazem HCl. Scholars Research Library, Der Pharmacia Lettre. 2012; 4(3):972-978.
42. Behera BC. Characterization of Glipizide-Loaded Polymethacrylate Microspheres Prepared by an Emulsion Solvent Evaporation Method. Tropical Journal of Pharmaceutical Research. 2008; 7(1):879-88.
43. Nachts S, Martin K. In: The microsponges a novel topical programmable delivery formulation, Marcel Dekker Inc. New York, 1990.
44. Hafeli U. Physics and Chemistry Basic of Biotechnology: Focus on biotechnology. Review: Radioactive Microspheres for Medical Application, 7:213-248
45. Li SP, Kowalski CR, Feld KM, Grim WM. Recent Advances in Microencapsulation Technology and Equipment. Drug Delivery Ind. Pharm. 1988; 14:353-76.