Author(s): V. Vyshali, N. Lalitha Jyotsna, Vasudha Bakshi, Syed Ismail, Dibyalochan Mohanty, T. Kavitha, M. Manoj

Email(s): dibyalochan.mohanty@gmail.com

DOI: 10.52711/0974-360X.2021.00802   

Address: V. Vyshali1, N. Lalitha Jyotsna1, Vasudha Bakshi2, Syed Ismail1, Dibyalochan Mohanty2, T. Kavitha1, M. Manoj1
1Department of Biotechnology, Anurag University (Formerly Lalitha College of Pharmacy) Venkatapur (V), Ranga Reddy - 500088, Telangana, India.
2Department of Pharmaceutics, Anurag University (Formerly Lalitha College of Pharmacy) Venkatapur (V), Ranga Reddy - 500088, Telangana, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 9,     Year - 2021


ABSTRACT:
In this study extraction of curcuminoids from turmeric was explored by various methods of extraction. For extraction soxhelet, ultrasonication and distillation methods were employed for separation of curcuminoids from turmeric powder under more or less varying same parameters. The results were analyzed and compared with reference method. The UV-Vis spectroscopy, HPLC and TLC were used for the confirmation and quantification of extract. The TLC analysis showed the three bands denoted the presence of three curcuminoids. The UV-Vis spectral analysis specified the absorption peak at 425nm. The HPLC studies implied the existence of three peaks for sonicated extract. The interpretation of the observation emphasized that the yield of extraction was higher for sonication method than remaining other extraction methods under varying parameters. Hence sonication method was considered as optimized extraction method which was time saving and less energy consuming favorable extraction method. The emphasized characteristics of improved extraction methods including cost-effectiveness (due to much saving in time and energy consumption) and environmentally benign nature make them more favourable extraction methods.


Cite this article:
V. Vyshali, N. Lalitha Jyotsna, Vasudha Bakshi, Syed Ismail, Dibyalochan Mohanty, T. Kavitha, M. Manoj. Optimization of Extraction of Curcuminoids from Turmeric Powder (Curcuma longa). Research Journal of Pharmacy and Technology. 2021; 14(9):4615-0. doi: 10.52711/0974-360X.2021.00802

Cite(Electronic):
V. Vyshali, N. Lalitha Jyotsna, Vasudha Bakshi, Syed Ismail, Dibyalochan Mohanty, T. Kavitha, M. Manoj. Optimization of Extraction of Curcuminoids from Turmeric Powder (Curcuma longa). Research Journal of Pharmacy and Technology. 2021; 14(9):4615-0. doi: 10.52711/0974-360X.2021.00802   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-9-16


REFERENCES:
1.    Sri Vasavi Reddy A, J. Suresh, A Review on Curcuma longa. Research Journal of Pharmacy and Technology. 2012; 5(2): 158-165.
2.    Arnab Samanta, Amitava Roy. Study of Various Formulations for Enhancement of Systemic Bioavailability of Curcumin. Research J. Pharm. and Tech. 2018; 11(2): 661-666.
3.    Anand P, Nair HB. Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo. Biochem. Pharmacol. 2010; 79(3): 330-338.
4.    Bong P. Spectral and Photophysical Behaviors of Curcumin and Curcuminoids. Bull. Korean Chem. Soc. 2000; 21(1): 81-86.
5.    Goel A, Kunnumakkara AB, Aggarwal BB. Curcumin as “curcumin”. from kitchen to clinic. Biochem. Pharma. 2008; 75(4): 787-809.
6.    Hatcher H, Planalp R, Cho J. Curcumin: from ancient medicine to current clinical trials. Cell. Mol. Life. Sci. 2008; 65: 1631-52.
7.    Lin JK, Pan MH, Recent studies on the biofunctions and biotransformations of curcumin. Biofactors. 2000; 13: 153–158.
8.    K.N. Pushpakumari, Naijo Varghese Purification and separation of individual curcuminoids from spent turmeric oleoresin, a by- product from curcumin production industry. IJPSR 2014; 5(8): 3246-3254.
9.    Deepak V. Dandekar, V. G. Gaikar. Hydrotropic Extraction of Curcuminoids from Turmeric. Separation Science and Technology. 2003; 38:5, 1185-1215.
10.    Om Prakash, Debarshi Kar Mahapatra. Development of a New Isolation Technique and Validated RP-HPLC method for Quercetin and Kaempferol from Azadirachta indica leaves. Asian J. Pharm. Ana. 2018; 8(3): 164-168.
11.    Yadav DK. Purity Evaluation of Curcuminoids in the Turmeric Extract Obtained by Accelerated Solvent Extraction. JAOAC Int. 2017; 100(3): 586-591
12.    Alupului, A., Călinescu, I. Microwave extraction of active principles from medicinal plants. UPB Science Bulletin. 2012; Series B 74.
13.    Anand. P. Curcumin and cancer: an “old-age” disease with an “age-old” solution. Cancer Letters. 2008; 267: 133-164.
14.    Azmir, Jetal Techniques for extraction of bioactive compounds from plant materials: a review. Journal of Food Engineering. 2013; 117: 426-436.
15.    Patil SS, Bhasarkar S. Extraction of curcuminoids from Curcuma longa: comparative study between batch extraction and novel three phase partitioning Prep Biochem Biotechnol. 2019; 49(4): 407-418.
16.    Bairwa, K., Grover, J. Recent developments in chemistry and biology of curcumin analogues. RSC advances. 2014; 4: 13946- 13978.
17.    Bar-Sela, G., Epelbaum, R. Curcumin as an anti-cancer agent: review of the gap between basic and clinical applications. Current Medicinal Chemistry. 2010; 17: 190-197.
18.    Chemat, F., Tomao, V. Ultrasound assisted extraction in food analysis. Hand Book of Food Analysis Instruments. 2008; 85-103.
19.    Chang, W.Y., Bin-Yusoff. Extraction of essential oil from Curcuma longa. Journal of Food Chemistry and Nutrition. 2014; 2, 01-10.
20.    Cravotto, G. Improved extraction of vegetable oils under high-intensity ultrasound and/or microwaves. Ultrasonics Sonochemistry. 2008; 15: 898-902.
21.    De Castro, M. L, Soxhlet extraction of solid materials: an outdated technique with a promising innovative future. Analytica Chimica Acta. 1998; 369, 1-10.
22.    Duvoix, A. Chemopreventive and therapeutic effects of curcumin. Cancer Letters. 2005; 223: 181-190.
23.    Sana Ilahi Mulla, Rutuja Rajendra Shah. Antibacterial Activity of Some Traditional Plants. Research J. Pharm. and Tech, 2018; 11(2): 766-768
24.    Aparna Satapathy, Mandava V. Rao. Protective effect of Curcumin on 2, 4- Dichlorophenoxy acetic acid exerted Hepatotoxicity in Mice. Research J. Pharm. and Tech. 2018; 11(2): 637-642.
25.    Sereya Koneru, G. Devala Rao. Development and Validation of Analytical Method for Standardization of Curcumin Using RP-HPLC Method in Prepared Extract. Research J. Pharm. and Tech. 2018; 11(4) 1580-1583.
26.    Y. Thejeswari, S. Rubesh Kumar. Amelioration and Affirmation for the Assessment of Curcumin in API and Ayurvedic Herbal Formulation Haridra Capsule by UFLC Discrete Method. Research J. Pharm. and Tech 2013; 6(9): 1051-1057.
27.    Li, M., Ngadi, M. O. Optimisation of pulsed ultrasonic and microwave-assisted extraction for curcuminoids by response surface methodology and kinetic study. Food Chemistry. 165: 29-34 (2014).
28.    Jayandran. M, Muhamed Haneefa. M. Synthesis, Characterization and Antimicrobial Activities of Turmeric Curcumin and Curcumin Stabilized Zinc Nanoparticles - A Green Approach. Research J. Pharm. and Tech. 2015; 8(4): 445-451.
29.    Tomar Hemant. Curcuma longa: Review of Advances in Pharmacology. Research Journal of Pharmacy and Technology. 2012; 5(9): 1141-1144.
30.    Rubesh Kumar S, Ram Kishan J. Simultaneous Spectrophotometric Estimation of Curcuminoids and Ascorbic Acid in Bulk Drug and Ayurvedic Polyherbal Tablet Dosage Form. Asian J. Research Chem. 3(3): July- Sept. 2010; Page 678-681.
31.    Panchawat S., Sisodia S.S. Comparative Evaluation/Optimization of Soxhlet, Ultrasonic and Microwave Assisted Extraction of Ficus religiosa Linn. Research J. Pharmacognosy and Phytochemistry.  2010; 2(4): 309-312
32.    MD Wandhare, UA Deokate. Comparative Estimation of Curcumin Content from Marketed Herbal Anti Rheumatic Tablets Formulation. Asian J. Research Chem. 2009; 2(3): 340-343
33.    Praveen Kumar Gupta, J.K. Pandit. Preparation of Diclofenac Diethylamine Nanoemulsions by Ultrasonication-Stability and Process Parameter Evaluation under Various Conditions. Research J. Pharma. Dosage Forms and Tech. 2011; 3(6): 285-293.
34.    Yogini S. Jaiswal, Pratima A. Tatke. Isolation and Quantitative Analysis of a Bioactive Polyphenol - Catechin in Anacardium occidentale Linn. (Leaves and Testa) by HPLC Analysis. Research J. Pharmacognosy and Phytochemistry. 2010; 2(5): 372-376.
35.    RS Jadhav, PN Kendre. RP- HPLC Method for Simultaneous Estimation of Ofloxacin and Ornidazole from Bulk and Tablets. Research J. Science and Tech. 2009; 1(1):43-46.
36.    Ch. M.M. Prasada Rao, Ravikumar Konda. Estimation of Nevirapine Anhydrous Bulk Formulation by Using IR, RP-HPLC, GC Methods. Research J. Pharm. and Tech. 2010; .3 (4): 1088-1092.
37.    V. Agrahari, M. Bajpai, S. Nanda. Essential Concepts of Mobile Phase Selection for Reversed Phase HPLC. Research J. Pharm. and Tech, 2013; 6(5): 459-464.
38.    Jadhao M.P, Bhusari KP, Shrikhande BK, Ghormade JM, Shrikhande VN. Development and Quantification 0f HPTLC Method for the Estimation of Kutkin in Picrorrhiza kurroa. Research J. Pharm. and Tech. 2009; 2 (4): 768-770.
39.    Patel Vishakha. D., Raj Hasumati. Ranolazine: A Review on Analytical Method and Its Determination in Synthetic Mixture. Asian J. Pharm. Ana. 2015; 5(4): 214-218.

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