Author(s):
Nilesh K. Patel, Bhumika H. Rana, Dhruti M. Patel, Amitkumar J. Vyas, Ashok B. Patel, Ajay I. Patel
Email(s):
ranabhumika777@gmail.com
DOI:
10.52711/0974-360X.2021.00789
Address:
Dr. Nilesh K. Patel1, Bhumika H. Rana1*, Dhruti M. Patel1, Dr. Amitkumar J. Vyas1, Dr. Ashok B. Patel1, Dr. Ajay I. Patel1
B.K. Mody Government Pharmacy College, Rajkot, Gujrat, India.
*Corresponding Author
Published In:
Volume - 14,
Issue - 9,
Year - 2021
ABSTRACT:
RP- UPLC method was developed and validated for the simultaneous determination of Rabeprazole sodium and Mosapride citrate in tablet dosage form. The separation was achieved on a BEH C18 (50mm × 2.1mm× 1.7µm) column using mobile phase of Ammonium acetate buffer: Acetonitrile (60:40% v/v). The flow rate was 0.4 ml/min and detection was carried out at 270nm and column oven 35ºC. Rabeprazole sodium and Mosapride citrate was subjected to stress condition including Acidic, Alkaline, Oxidation, Photolysis and Thermal degradation. This method was validated as per ICH (Q2R1) guideline.
Cite this article:
Nilesh K. Patel, Bhumika H. Rana, Dhruti M. Patel, Amitkumar J. Vyas, Ashok B. Patel, Ajay I. Patel. Stability Indicating RP-UPLC Method for Simultaneous Estimation of Rabeprazole Sodium and Mosapride Citrate in Tablet Dosage form. Research Journal of Pharmacy and Technology. 2021; 14(9):4535-9. doi: 10.52711/0974-360X.2021.00789
Cite(Electronic):
Nilesh K. Patel, Bhumika H. Rana, Dhruti M. Patel, Amitkumar J. Vyas, Ashok B. Patel, Ajay I. Patel. Stability Indicating RP-UPLC Method for Simultaneous Estimation of Rabeprazole Sodium and Mosapride Citrate in Tablet Dosage form. Research Journal of Pharmacy and Technology. 2021; 14(9):4535-9. doi: 10.52711/0974-360X.2021.00789 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-9-3
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