Thimmasetty J, Shashank NN, Abdul Raheem T, Shwetha SKK, Tanmoy G
Thimmasetty J1, Shashank NN1, Abdul Raheem T1*, Shwetha SKK1, Tanmoy G2
1Deptartment of Pharmaceutics, Bapuji Pharmacy College, Davangere, Karnataka, India.
2Department of Pharmaceutics, Faculty of Pharmacy, MS Ramaiah University of Applied Sciences, Bangalore, Karnataka, India.
Volume - 14,
Issue - 9,
Year - 2021
The present investigation was designed to prepare and characterize BCS class II drug modafinil cocrystals for its solubility enhancement and other properties. Hansen solubility parameter (HSP) was used for prediction of cocrystal formation. Coformers/excipients namely boric acid, cinnamic acid, salicylic acid, and tartaric acid were used in the preparation of cocrystals by liquid assisted grinding method with 1:1 molar ratio of drug and coformer. The prepared cocrystals were subjected to characterization by performing melting point determination, solubility analysis at its saturation point, and drug release by in vitro method. Furthermore, characterization was also done by Fourier Transform IR spectroscopy, Differential Scanning Calorimetry, PXRD and Scanning Electron Microscopy. The formation of modafinil cocrystals by using cinnamic acid and salicylic acid and the formation of modafinil complexes with boric acid and tartaric acid were confirmed by collectively assessing the results. Moreover, a drastic improvement in the solubility revealed the importance of preparing pharmaceutically useful cocrystals of marketed active pharmaceutical ingredients (APIs). However, the increased dissolution rates were seen with cocrystals but not with the complexes. Thus solid state manipulation technique can be used to improve the physicochemical properties of an API using HSP as a successful tool for the prediction of cocrystal formation among the partners.
Cite this article:
Thimmasetty J, Shashank NN, Abdul Raheem T, Shwetha SKK, Tanmoy G. Modafinil Cocrystals for Altered Physicochemical Properties. Research Journal of Pharmacy and Technology. 2021; 14(9):4891-6. doi: 10.52711/0974-360X.2021.00850
Thimmasetty J, Shashank NN, Abdul Raheem T, Shwetha SKK, Tanmoy G. Modafinil Cocrystals for Altered Physicochemical Properties. Research Journal of Pharmacy and Technology. 2021; 14(9):4891-6. doi: 10.52711/0974-360X.2021.00850 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-9-64
1. Sinha AS, Maguire AR, Lawrence SE. Cocrystallization of nutraceuticals. Crystal Growth and Design 2015; 15(2): 984-1009.
2. Raheem Thayyil A, Juturu T, Nayak S, Kamath S. Pharmaceutical co-crystallization: Regulatory aspects, design, characterization, and applications. Advanced Pharmaceutical Bulletin 2020; 10(2): 203-12.
3. Jino ET, Usha YN Jagadish PC, Koteshwara KB. Design and characterization of valsartan co-crystals to improve its aqueous solubility and dissolution behaviour. Research Journal of Pharmacy and Technology 2017; 10(1): 26-30.
4. Yadav AV, Shete AS, Dabke AP, Kulkarni PV, Sakhare SS. Co-crystals: A novel approach to modify physicochemical properties of active pharmaceutical ingredients. Indian Journal Pharmaceutical Science 2009; 71(4): 359-70.
5. Mohammad MA, Alhalaweh A, Velaga SP. Hansen solubility parameter as a tool to predict cocrystal formation. International Journal of Pharmaceutics 2011; 407(1): 63-71.
6. Dauvilliers Y, Roth T, Guinta D, Alvarez-Horine S, Dynin E, Black J. Effect of sodium oxybate, modafinil, and their combination on disrupted nighttime sleep in narcolepsy. Sleep Medicine 2017; 40: 53-7.