Objective: The aim of the present study was to increase the absolute bioavailability of famotidine, enhanced patient compliance in the treatment of peptic ulcer by increasing its gastric residence time and controlled local release of drug upto 12 hours. Materials and Methods: Hydrodynamically balanced capsules of famotidine were prepared, consisting of floating matrix granules, which formed hydrogels. Effects of different formulation variables namely hypromellose (HPMC 4000 cps, HPMC 5600 cps, HPMC 15000 cps), effervescent agent (potassium bicarbonate) and mixing time were studied. Optimization study included 23 full factorial design with t50% and t80% as the kinetic parameters (response variable). Matrix characterization included scanning electron microscopy. All prepared formulations were evaluated to various parameters such as micromeritics properties, % buoyancy and in vitro drug release studies. Results and Discussion: The optimized formulation (F4) remains buoyant for more than 12 hrs. The in-vitro drug release study indicated that increasing the viscosity of HPMC resulted in sustained drug release with long floating duration. SEM studies showed definite entrapment of the drug in the matrix and hydrogel formation. Results showed a pH independent but polymer viscosity dependent drug release profile. The release kinetics followed Higuchi model and mechanism of release was found to be non-Fickian diffusion. Conclusion: Famotidine-loaded hydrodynamically balanced capsules were successfully prepared and prove to be useful for prolonged gastric residence of the drug, better bioavailability, patient compliance and improve delivery for enhanced anti-ulcer activity.
Cite this article:
Ritesh Kumar, Kashmira J. Gohil. Hydrodynamically Balanced Capsule of Famotidine: An Improved Delivery via Gastroretentive Hydrogels. Research Journal of Pharmacy and Technology. 2021; 14(9):4573-9. doi: 10.52711/0974-360X.2021.00795
Ritesh Kumar, Kashmira J. Gohil. Hydrodynamically Balanced Capsule of Famotidine: An Improved Delivery via Gastroretentive Hydrogels. Research Journal of Pharmacy and Technology. 2021; 14(9):4573-9. doi: 10.52711/0974-360X.2021.00795 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-9-9
1. Gilman AG, Rall TW and Taylor P. Goodman and Gillman’s The Pharmacological Basis of Therapeutics. McGraw- Hill, New York. 1990.
2. Kumar R, Philip A. Gastroretentive dosage forms for prolonging gastric residence time. International Journal of Pharmaceutical Medicine. 2007; 21(2): 157-1571.
3. Kumar S, Rahaman A, Tyagi LK, Chandra A. Floating drug delivery system: A novel approach for gastroretentive drug delivery. Research Journal of Pharmacy and Technology. 2011; 4(7): 1026-1032.
4. Suradkar P, Mishra R, Nandgude T. Overview on trends in development of gastroretentive drug delivery system. Research Journal of Pharmacy and Technology. 2019; 12(11): 5633-5640.
5. Chauhan YS, Kataria U, Dashora A. Importance of floating drug delivery system. Research Journal of Pharmaceutical Dosage Forms and Technology. 2018; 10(4): 220-232.
6. Kumar R. Development and in vitro evaluation of sustained release floating matrix tablets of metformin hydrochloride. International Journal of Pharmaceutical Sciences and Research. 2010; 1(8): 96-101.
7. Kumar R, Gautam PK, Chandra A. Formulation and evaluation of multiple unit floating beads of antiulcer drug. Asian Journal of Pharmaceutics. 2018; 12 (2): S681-S690.
8. Daharwal SJ, Thakur VD, Shrivastava S, Sahu BP. Designing and optimization of medicated chewing gum of ambroxol HCl by using 32 factorial design. Asian Journal of Pharmaceutical Research. 2013; 3(3): 118-120.
9. Martin A. Physical pharmacy. B I Waverly Pvt Ltd, New Delhi. 1996.
10. Aulton ME. Pharmaceutics: The Science of Dosage form Design. Churchill Livingstone, London. 2002.
11. Gayakwad BP, Barhate SD, Jain MS. Citric acid cross linked cellulose based hydrogel for drug delivery. Asian Journal of Pharmaceutical Research. 2017; 7(4): 247-255.
12. Kumar R, Gupta S, Chandra A, Gautam PK. Floating tablets: A realistic approach in gastroretentive drug delivery system. International Journal of Pharmaceutical Research & Bioscience. 2016; 5: 1-20.
13. Lokhande SS. Recent trends in development of gastro-retentive floating drug delivery system: A Review. Asian Journal of Pharmaceutical Research. 2019; 9(2): 91-96.
14. Singh BN, Kim KH. Floating drug delivery systems: An approach to oral controlled drug delivery via gastric retention. Journal of Controlled Release. 2000; 63: 235-259.
15. Baggi RB. A principal component analysis-based method for testing deviation from ideal zero order release: An orthodox approach. Asian Journal of Pharmacy and Technology. 2019; 9(1): 15-22.
16. Kumar R, Chandra A, Gautam PK. Development and validation of UV spectrophotometric method for quantitative estimation of famotidine in bulk and tablet dosage form. Asian Journal of Pharmaceutical & Clinical Research. 2017; 10 (8): 381-385.
17. Yang L, Fassihi R. Zero order release kinetics from self correcting floatable configuration drug delivery system. Journal of Pharmaceutical Sciences. 1996; 85: 170-173.
18. Patel N, Patel J, Moin Modasiya. Formulation and in vitro evaluation of glipizide as floating drug delivery system. Asian Journal of Pharmacy and Technology. 2012; 2(2): 67-73.
19. Mulye NV, Turco SJ. A simple model based on first order kinetics to explain release of highly water soluble drugs from porous dicalcium phosphate dihydrate matrices. Drug Development and Industrial Pharmacy. 1995; 21(8): 943-953.
20. Higuchi T. Mechanism of sustained action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. Journal of Pharmaceutical Sciences. 1963; 52 (12): 1145-1149.
21. Korsmeyer RW, Gurny R, Doelker EM, Buri P, Peppas NA. Mechanism of solute release from porous hydrophilic polymers. International Journal of Pharmaceutics. 1983; 15 (1): 25-35.
22. Kumar R, Chandra A, Garg S. Formulation and in vitro evaluation of sustained release gastroretentive tablets of metformin hydrochloride. International Journal of Therapeutic Application. 2012; 7: 13-17.
23. Garg R, Gupta GD. Development and characterization of cellulose and eudragit gastroretentive floating microspheres of acyclovir. Research Journal of Pharmacy and Technology. 2009; 2(1): 101-105.
24. Kumar R, Gautam PK, Chandra A. Formulation and evaluation of famotidine microballoons with enhanced anti-ulcer activity. International Journal of Applied Pharmaceutics. 2018; 10(3): 131-140.
25. Bolton S. Pharmaceutical statistics practical and clinical applications. Marcel Decker Inc, New York. 2004.
26. Kumar R, Chandra A, Saloni S, Gautam PK. Advanced multiple unit controlled release floating beads: A review. World Journal of Pharmaceutical Research. 2017; 6(15): 238-259.
27. Mehta M, Neeta, Pandey P, Mahajan S, Satija S. Gastroretentive drug delivery systems: An overview. Research Journal of Pharmacy and Technology. 2018; 11(5): 2157-2160.
28. Kumar R, Kamboj S, Chandra A, Gautam PK. Microballoons: An advance avenue for gastroretentive drug delivery system - A review. UK Journal of Pharmaceutical and Biosciences. 2016; 4(4): 19-30.
29. Waghmare SS, Kadam TV, Darekar AB, Saudagar RB. A review: Floatable gastroretentive drug delivery system. Asian Journal of Pharmaceutical Research. 2015; 5(1): 51-60.