Author(s): Neelottama Kushwaha, C.S. Sharma

Email(s): neelottama@gmail.com

DOI: 10.52711/0974-360X.2022.00039   

Address: Neelottama Kushwaha1,2*, C.S. Sharma3
1Department of Pharmacy, Pranveer Singh Institute of Technology, Kanpur-209305, UP., India.
2Ph.D. Scholar, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Bhupal Nobles’ University, Udaipur, Rajasthan-313001, India.
3Associate Professor, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Bhupal Nobles’ University, Udaipur, Rajasthan-313001, India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 1,     Year - 2022


ABSTRACT:
A series of 6-(chloromethyl)-N2-(1-(4-substituted phenyl)-3-phenyl-1H-pyrazol-4-yl) methylene)-N4-aryl-1, 3, 5-triazine - 2, 4-diamine 7(Aa-Gd) were synthesized using the appropriate synthetic procedure and characterized by spectral analysis. All the synthesized compounds were evaluated for their antibacterial and antifungal activities. The antibacterial activity was evaluated against Gram-positive strains (Staphylococcus aureus, Streptococcus aureus) and Gram-negative strains (Escherichia coli, Pseudomonas aeruginosa) using benzyl penicillin and streptomycin as standard drugs. Further, these compounds were studied for antifungal activity against three strains of fungi (Candida albicans, Aspergillus fumigate and Aspergillus flavus) using Ketoconazole as a standard drug. In the presented study all the synthesized compounds showed significant antibacterial and antifungal activities.


Cite this article:
Neelottama Kushwaha, C.S. Sharma. Synthesis of Novel 6-(chloromethyl) - N2- (1 - (4-substituted phenyl) - 3-phenyl - 1H-pyrazol - 4-yl) methylene)-N4- aryl-1, 3, 5-triazine - 2, 4-diamine derivatives and their Antimicrobial Activity. Research Journal of Pharmacy and Technology. 2022; 15(1):236-4. doi: 10.52711/0974-360X.2022.00039

Cite(Electronic):
Neelottama Kushwaha, C.S. Sharma. Synthesis of Novel 6-(chloromethyl) - N2- (1 - (4-substituted phenyl) - 3-phenyl - 1H-pyrazol - 4-yl) methylene)-N4- aryl-1, 3, 5-triazine - 2, 4-diamine derivatives and their Antimicrobial Activity. Research Journal of Pharmacy and Technology. 2022; 15(1):236-4. doi: 10.52711/0974-360X.2022.00039   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2022-15-1-39


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