Author(s): Annapurna Anusha Kotwala, M. Komala

Email(s): komala.sps@velsuniv.ac.in

DOI: 10.52711/0974-360X.2022.00763   

Address: Annapurna Anusha Kotwala*, M. Komala*
Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies (VISTAS), Chennai - 600117, Tamilnadu, India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 10,     Year - 2022


ABSTRACT:
Clofarabine is a second-generation purine nucleoside analogue with antineoplastic activity. The objective of this study was to prepare the Clofarabine nanoparticles loaded as OLEO-ALGINATE-ESTER conjugate, that OLEO-ALGINATE-ESTER conjugate could self-assemble to form nanoparticles when dissolved in water and the sparingly soluble Clofarabine could be entrapped within nanoparticles that stabilizes the Clofarabine in aqueous medium. Clofarabine loaded OLEO-ALGINATE-ESTER nanoparticles (Clofarabine-OLEO-ALGINATE-ESTER Nps) were prepared by simple ultra-sonication method. Meanwhile, the physiochemical characteristics of Clofarabine-OEA-Nps including particle-size and its distribution, zeta potential, drug entrapment efficiency and in-vitro drug release studies were determined. Furthermore, the cytotoxicity and cellular uptake of conjugated nanoparticles in to cancer cell linings were investigated.


Cite this article:
Annapurna Anusha Kotwala, M. Komala. Fabrication and Cytotoxic activity of Sodium Alginate Ester Nanoparticles Loaded with Clofarabine on MCF-7 cell linings. Research Journal of Pharmacy and Technology2022; 15(10):4547-2. doi: 10.52711/0974-360X.2022.00763

Cite(Electronic):
Annapurna Anusha Kotwala, M. Komala. Fabrication and Cytotoxic activity of Sodium Alginate Ester Nanoparticles Loaded with Clofarabine on MCF-7 cell linings. Research Journal of Pharmacy and Technology2022; 15(10):4547-2. doi: 10.52711/0974-360X.2022.00763   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2022-15-10-36


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