Author(s):
Ni NyomanYuliani, Jefrin Sambara, Sandeep Poddar, Urmisha Das
Email(s):
sandeeppoddar@lincoln.edu.my
DOI:
10.52711/0974-360X.2022.00878 
Address:
Ni NyomanYuliani1, Jefrin Sambara1, Sandeep Poddar2, Urmisha Das2
1Department of Pharmacy, Kupang Health Polytechnic of Health Ministry, Indonesia
2Lincoln University College, Wisma Lincoln, No, 12-18, Jalan SS 6/12, 47301 Petaling Jaya, Selangor D. E., Malaysia
*Corresponding Author
Published In:
Volume - 15,
Issue - 11,
Year - 2022
ABSTRACT:
Introduction: Katuk Leaf (Sauropus androgynus L. Merr.) from Kupang, East Nusa Tenggara, Indonesia is a type of plant that contains chalcone which is used as an antioxidant. This study aims to formulate a gel preparation from Katuk Leaf extract using various concentrations of CMC-Na and carbopol 940, to see the stability of the physical properties of the Katuk leaf extract gel Sauropus androgynus (L.) Merr. Methods: Katuk Leaf Extract was obtained by percolation method using 70% ethanol as solvent. The gels were made in formulas 1, 2, 3, 4, and 5 with a concentration of CMC-Na and carbopol 940 at 0:10; 1:9; 2:8; 9:1; 10:0 ratio. Antioxidant activity was tested with DPPH, observed for its physical stability including organoleptic, homogeneity, viscosity, pH dispersion, adhesion, and gel stability using the process of freeze thaw action. Results: The results showed that the concentration of carbopol 940 increased viscosity and adhesion and decreased dispersion and pH, while CMC-Na increased dispersion and pH and decreased viscosity and adhesion in the physical properties of the Katuk Leaf extract gel. Test results with IC50 extracts of Katuk Leaves at 73.815 ppm, showed that the formula 3 with a concentration of carbopol 940 and CMC-Na at 2: 8 percent by ratio, is a gel with antioxidant activity being most effective with the value of the IC50 100.814. Conclusion:So, it can be concluded that the stability of the physical properties of the gel shows the formula 3 with concentration carbopol 940 and CMC-Na at 2%: 8% gel with the best stability of physical properties.
Cite this article:
Ni NyomanYuliani, Jefrin Sambara, Sandeep Poddar, Urmisha Das. Formulation and characterization of Sauropus androgynous (L) Merr leaf extract Gel in Combination with CMC-Na and Carbopol 940 Using DPPH Method. Research Journal of Pharmacy and Technology. 2022; 15(11):5211-6. doi: 10.52711/0974-360X.2022.00878
Cite(Electronic):
Ni NyomanYuliani, Jefrin Sambara, Sandeep Poddar, Urmisha Das. Formulation and characterization of Sauropus androgynous (L) Merr leaf extract Gel in Combination with CMC-Na and Carbopol 940 Using DPPH Method. Research Journal of Pharmacy and Technology. 2022; 15(11):5211-6. doi: 10.52711/0974-360X.2022.00878 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2022-15-11-63
REFERENCES:
1. Widiawati W. Perbedaan Hasil PenyembuhanKulitWajahBerjerawat Antara Masker LidahBuayaDengan Masker Non LidahBuaya. Jurnal Tata Rias. 2014 28; 3(01).
2. Kusantati H. Prihatin PT. Wiana W. Tata kecantikankulit. Direktorat Pembinaan Sekolah Menengah Kejuruan, Jakarta. 2008.
3. Jusuf NK. Menua K. Majalah Kedokteran Nusantara, 2, 2005. 184-188.
4. Sembiring BB. Manoi F. Identifikasi Mutu Tanaman Ashitaba. Buletin Penelitian Tanaman Rempah dan 2011 22(2) 177-185. DOI: http://dx.doi.org/10.21082/bullittro.v22n2.2011.%25p
5. Lieberman HA. Rieger MM. Banker GS. Editors Pharmaceutical Dosage Forms--disperse Systems. Dekker; 1988. https://doi.org/10.1002/jps.2600790927
6. Sharon N. Anam S. Yuliet Y. Formulasi Krim Antioksidan Ekstrak Etanol Bawang Hutan (Eleutherine palmifolia L. Merr). Natural Science: Journal of Science and Technology. 2013 30; 2(3).
7. Voigt R. Buku Pelajaran Teknologi Farmasi, diterjemahkan oleh Soendani NS, Yogyakarta. Universitas Gajah Mada Press. 1994. Online Access:http://katalogdisperpusipprovjambi.perpusnas.go.id/detail-opac?id=10904
8. Safitri FI. Nawangsari D. Febrina D. Overview: Application of Carbopol 940 in Gel. InInternational Conference on Health and Medical Sciences (AHMS 2020) 2021 27 (pp. 80-84). Atlantis Press. DOI https://doi.org/10.2991/ahsr.k.210127.018
9. Rowe RC. Sheskey P J. Quinn M E. Handbook of pharmaceutical excipients. Libros Digitales-Pharmaceutical Press; 2009.506-509
10. Husni A. Putra DR. Lelana IY. Aktivit Asantioksidan Padina Sp. Pada Berbagai Suhu Dan Lama Pengeringan. Jurnal Pascapanen dan Bioteknologi Kelautan dan Perikanan. 2014 25; 9(2):165-73. DOI: http://dx.doi.org/10.15578/jpbkp.v9i2.109
11. He JR. Zhu JJ. Yin SW. Yang XQ. Bio accessibility and intracellular antioxidant activity of phloretin embodied by gliadin/sodium carboxymethyl cellulose nanoparticles. Food Hydrocolloids. 2022 1; 122:107076. https://doi.org/10.1016/j.foodhyd.2021.107076
12. Patil SB. Naikwade NS. Magdum CS. Awale VB. Some medicinal plants used by people of Sangli district, Maharashtra. Asian Journal of Pharmaceutical Research. 2011;1(2):53-54 Available at: http://ischolar.info/index.php/Ajpr/article/view/152430
13. Venkateshwarlu G. Ragyanaik E. Swapna K. Santhosh A. Santhosh CH. Vitex trifolia-An Important Medicinal Plant: A Review of Its Folklore Medicine and Traditional Uses. Asian Journal of Pharmaceutical Research. 2014;4(2):70-1.
14. Venkateshwarlu G. Eslavath R. Santhosh A. Suma G. Rajeshwari E. Ramesh CH. Rephanus sativa-An Important Medicinal Plant: A Review of Its Folklore Medicine and Traditional Uses. Asian Journal of Pharmaceutical Research. 2014;4(3):160-1. Availableon: https://asianjpr.com/AbstractView.aspx?PID=2014-4-3-6
15. Qureshi MS. Reddy AV. Kumar GS. Nousheen L. Ethnobotanical study on Medicinal Plants used by Traditional Health Practitioners and Villagers of Garhphulghar Gram, Chhattisgarh, India. Asian Journal of Pharmaceutical Research 2017; 7(2):98-105. DOI: 10.5958/2231-5691.2017.00017.X
16. Aseena R. Zaidi SZ. Rasheed N. Mohammad AS. Anti-Asthmatic, Analgesic and Anti-Convulsant activities of the medicinal plant Bryonia laciniosa. Linn. Contributors. Asian Journal of Pharmaceutical Research. 2017 1;7(4). DOI: http://dx.doi.org/10.5958/2231-5691.2017.00040.5
17. Patil NB. Patil KB. Kshirsagar SS. Medicinal plant is new Horizones in Spinocerebellar ataxia. Asian Journal of Pharmaceutical Research. 2020;10(1):29-30. DOI : http://dx.doi.org/10.5958/2231-5691.2020.00006.4
18. Rohini CK, Rajesh YC. A review on phytopharmacological profile of traditionally used medicinal plant Parkiabiglandulosa (Mimosaceae). Asian Journal of Pharmaceutical Research. 2020; 10(1):34-8. DOI: 10.5958/2231-5691.2020.00008.8
19. Madhu C. Swapna J. Neelima K. Shah MV. A comparative evaluation of the antioxidant activity of some medicinal plants popularly used in India. Asian Journal of Research in Pharmaceutical Science. 2012; 2(3):98-100. Available at: http://ischolar.info/index.php/Ajrps/article/view/59769
20. Venkateshwarlu G. Eslavath R. Santhosh A, Suma G. Ramakka D. Sankirthi S. Ficus religiosa-an Important Medicinal Plant: A Review of Its Folklore Medicine and Traditional Uses. Asian Journal of Research in Pharmaceutical Science. 2014; 4(1):26-7.
21. Soni S. Kumar P. Verma VS. Sharma M. Significance of Indian medicinal plants used for treatment of dementia. Asian Journal of Research in Pharmaceutical Science. 2014; 4(4):202-5.
22. Surya M, Zuriati Z, Poddar S. Nursing aromatherapy using lavender with rose essence oil for post-surgery pain management. Enfermeria clinica. 2020 1; 30:171-4. DOI https://doi.org/10.1016/j.enfcli.2020.02.001
23. Dey, S. R., Dutta, S., and De, M. (2020). Neuro-Steroid Compound Found by GC-MS Analysis of The Methanolic Extract of The Leaves of Aegle marmelos (L) Corr. International Journal of Advancement in Life Sciences Research, 3(4), 51-56. DOI https://doi.org/10.31632/ijalsr.20.v03i04.006
24. Poddar S. Dietary intervention with iron and black tea infusion in reducing cytotoxicity of arsenic. IJEB Vol.42(09) 2004: 900-903.
25. Hamzah FN. Sujarwo W. Septama AW. Mozef T. Antioxidant and Xanthine Oxidase Inhibitory Activities of Kecapi (Sandoricum koetjape (Burm. f) Merr.) Leaf Extract. InIOP Conference Series: Materials Science and Engineering 2020 1 (Vol. 833, No. 1, p. 012012). IOP Publishing.
26. Priscilia B. Novita H. Elya B. Antioxidant and antibacterial assay against fish pathogen bacteria of Kjellbergiodendron celebicum (Koord.) Merr. leaf extract. Pharmacognosy Journal. 2020;12(1). DOI:10.5530/pj.2020.12.26
27. Hikmawanti NP. Fatmawati S. Asri AW. The Effect of Ethanol Concentrations as The Extraction Solvent on Antioxidant Activity of Katuk (Sauropus androgynus (L.) Merr.) Leaves Extracts. In IOP Conference Series: Earth and Environmental Science 2021 1 (Vol. 755, No. 1, p. 012060). IOP Publishing. DOI: 10.1088/1755-1315/755/1/012060