Khairil Azwan, Resni Mona, Jannathul Firdous, Dina Keumala Sari, Pamela Rosie David, Noorzaid Muhamad
Khairil Azwan1, Resni Mona1, Jannathul Firdous1, Dina Keumala Sari3, Pamela Rosie David2, Noorzaid Muhamad1*
1Cluster for Integrative Physiology and Molecular Medicine (CIPMM), Faculty of Medicine, Royal College of Medicine Perak, Universiti Kuala Lumpur, Jalan Greentown, 30450 Ipoh, Perak, Malaysia.
2Department of Anatomy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
3Nutrition Department, Faculty of Medicine, Universitas Sumatera Utara, Indonesia.
Volume - 15,
Issue - 2,
Year - 2022
Metabolic syndrome is a grouping of several medical conditions plaguing the modern world today. Excessive visceral fat is strongly associated with abdominal obesity which is one of the characteristics of metabolic syndrome. In general, an unbalanced, rich diet plays an important role in the proliferation of adipocytes. Our aim is to observe which diet contributes to the deposition of visceral fat such as the mesenteric fat. For eight weeks, thirty-five Sprague Dawley rats were divided into five groups and were fed five different types of diets. The five diets are normal rat chow, high sugar, high starch, high protein and high fat rat (palm oil-based) feed formula. Besides the formularized rat feeds, the rats were given tap water ad libitum. The result showed high fat diet promotes mesenteric fat proliferation when compared to other rat feed formula. Present study showed that high-fat diet promotes mesenteric fat proliferation when compared to other diets.
Cite this article:
Khairil Azwan, Resni Mona, Jannathul Firdous, Dina Keumala Sari, Pamela Rosie David, Noorzaid Muhamad. Eight weeks consumption of high-fat diet promotes Mesenteric fat deposition when compared to other rat diets. Research Journal of Pharmacy and Technology. 2022; 15(2):571-4. doi: 10.52711/0974-360X.2022.00093
Khairil Azwan, Resni Mona, Jannathul Firdous, Dina Keumala Sari, Pamela Rosie David, Noorzaid Muhamad. Eight weeks consumption of high-fat diet promotes Mesenteric fat deposition when compared to other rat diets. Research Journal of Pharmacy and Technology. 2022; 15(2):571-4. doi: 10.52711/0974-360X.2022.00093 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2022-15-2-13
1. Manjula B, Rayappa Hunasagi and Shivalinge Gowda KP. Anti-Obesity Activity of Ethanolic Extract of Moringa oleifera Seeds in Experimental Animals. Research J. Pharmacology and Pharmacodynamics. 2011; 3(6): 318-328.
2. Rohit Gundamaraju Diana Vivian Atigari, DS Helen Sheeba, Ramesh C. Evaluation of anti-obesity activity of Lantana camara var Linn on butter induced Hyperlipidemia in Rats. Research J. Pharmacology and Pharmacodynamics. 2012; 4(5): 315-318.
3. Malik VS, Willett WC, Hu FB. Global obesity: trends, risk factors and policy implications. Nat Rev Endocrinol. 9(1); 2013: 13-27.
4. Preeti Tiwari. Antihyperlipidemic Potential of Balarishta Prepared by Traditional and Modern Methods in High Fat Diet Induced Hyperlipidemic rats. Asian J. Res. Pharm. Sci. 2014; 4(11): 07-11.
5. Seema Thakur, Neha Srivastava. Nutraceuticals: A Review. Asian J. Res. Pharm. Sci. 2016; 6(2): 85-94. doi: 10.5958/2231-5659.2016.00012.6
6. Ritu Rana. How to approach ‘Fat-tax’ on food to tackle Non-communicable diseases in India: A Review. Res. J. Humanities and Social Sciences. 2019; 10(2):291-297. doi: 10.5958/2321-5828.2019.00052.4
7. Panchal SK, Brown LJ. Rodent models for metabolic syndrome research. Biomed Biotechnol. 2011: 351982.
8. Buettner R, Schölmerich J, Bollheimer LC. High-fat diets: modeling the metabolic disorders of human obesity in rodents. Obesity (Silver Spring). 15(4); 2007:798-808.
9. A. Sowmya, T. Ananthi. Hypolipidemic activity of Mimosa pudica Linn on Butter Induced Hyperlipidemia in Rats. Asian J. Res. Pharm. Sci. 2011; 1(4): 123-126.
10. Abhijit Ray. Application of Lipase in Industry. Asian J. Pharm. 2012; 2(2): 33-37.
11. Nitin Mahurkar, S.M Sayeed ul hasan, S. Mutaal Quadri. Antihyperlipidemic Effect of Polyherbal Formulation (PHF) in High Fat Diet Induced Hyperlipidemia. Res. J. Pharm. Dosage Form. and Tech. 2015; 7(1): 11-14. doi: 10.5958/0975-4377.2015.00003.8
12. Ravindra Babu. S, Priyanka Goud. K. Evaluation of Anti-Hyperlipidemic and Anti Oxidant Activity of Ethanolic Extract of Delonix Elata on High fat diet Induced Rats. Res. J. Pharmacognosy and Phytochem. 2018; 10(3): 241-245. doi: 10.5958/0975-4385.2018.00039.0
13. Ashwini Gangoni, Suneetha B, Sunanda S, Ravindrababu S. Hypolipidemic and Antioxidant Activity of Methanolic Leaf Extract of Ochna obtusata on High Fat Diet Induced Obesity in Rats. Research Journal of Pharmacology and Pharmacodynamics. 2015; 7(1): 1-4. doi: 10.5958/2321-5836.2015.00001.4
14. Marques C, Meireles M, Norberto S, Leite J, Freitas J, Pestana D, Calhau, C. High-fat diet-induced obesity Rat model: a comparison between Wistar and Sprague-Dawley Rat. Adipocyte. 5(1); 2015: 11–21.
15. Grundleger ML, Thenen SW. De-creased insulin binding, glucose trans-port and glucose metabolism in soleus muscle of rats fed a high fat diet. Diabetes. 31; 1982:232–23721.
16. Oakes ND, Cooney GJ, Camilleri S,Chisholm DJ, Kraegen, EW. Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding. Diabetes. 46; 1997:1768–1774
17. Lozano I, Van der Werf R, Bietiger W. High-fructose and high-fat diet-induced disorders in rats: impact on diabetes risk, hepatic and vascular complications. Nutr Metabolism. 13; 2016: 15.
18. Cuthbertson, Daniel; Smith, Kenneth; Babraj, John; Leese, Graham; Waddell, Tom Atherton, Philip; Wackerhage, Henning; Taylor, Peter M, Rennie, Michael J. Anabolic deficits underlie amino acid resistance of wasting, aging muscle. The FASEB Journal. 19 (3); 2005: 422–424.
19. Lin YW, Park SW, Lin YL, Burton FH, Wei LN. Cellular retinoic acid binding protein 1 protects mice from high-fat diet-induced obesity by decreasing adipocyte hypertrophy. Int J Obes (Lond). 44(2); 2020:466-474.
20. Poret, JM, Souza-Smith, F, Marcell SJ, Gaudet DA, Tzeng TH, Braymer HD, Harrison-Bernard LM, Primeaux SD. High fat diet consumption differentially affects adipose tissue inflammation and adipocyte size in obesity-prone and obesity-resistant rats. International Journal of Obesity. 42(3); 2005: 535–541.
21. Sarah A, Stanley. Nature vs. nurture in adipocyte responses to high-fat feeding, Science Translational Medicine. 8(348); 2016: 348ec116.
22. Cinti S, Fantuzzi G, Mazzone T. The adipose organ Nutrition and health: adipose tissue and adipokines in health and disease . Totowa: Human Press Inc 19; 2007: 3–19.
23. Nivoit P, Morens V, Van Assche FA, Jansen E, Poston L, Remacle C, Reusens B. Established diet-induced obesity in female rats leads to offspring hyperphagia, adiposity and insulin resistance. Diabetologia 52(6); 2009: 1133-1142.
24. De Sousa AG, Cercato C, Mancini MC, Halpern A. Obesity and obstructive sleep apnea-hypopnea syndrome. Obes Rev 9(4); 2004: 340-354.