ABSTRACT:
The blood glucose level of the body tends to increase slightly after the age of 50. The coriander (Coriandrum sativum L) is a member of the Apiaceae family and it grows in a wide range conditions and can be used as antidiabetic. The purpose of this study was to determine the effect of coriander water extract on the blood sugar levels of white rats (Rattus norvegicus strain wistar). The method of this study involved experimental animals, specifically 20 Rattus norvegicus strain wistar ranging from 150-200grams with an age between 2-3 months. The mice were injected with an alloxan solution to induce a diabetic condition and then they were divided into four groups and treated. The treatments were 0.5% Na CMC, glibenclamide 0.45mg/Kg b.w, coriander extract of 100mg/Kg b.w and coriander extract of 200mg/Kg b.w for 15 days. The blood glucose level of the mice was measured on days 0, 1, 5, 10 and 15. The results showed that the 0.5% CMC placebo had no effect in terms of reducing the glucose level of the rats, Glibenclamide 0.45mg/Kg b.w had an effect in terms of reducing the blood glucose level, as did coriander extract 100mg/Kg b.w and 200mg/Kg b.w among the alloxan-diabetic mice.
Cite this article:
Ainun Sajidah, Evi Risa Mariana, Zainab. Effect of Coriandrum sativum L on Blood Glucose Levels among Alloxan- Diabetic Mice (Rattus norvegicus strain wistar). Research Journal of Pharmacy and Technology. 2022; 15(2):736-0. doi: 10.52711/0974-360X.2022.00122
Cite(Electronic):
Ainun Sajidah, Evi Risa Mariana, Zainab. Effect of Coriandrum sativum L on Blood Glucose Levels among Alloxan- Diabetic Mice (Rattus norvegicus strain wistar). Research Journal of Pharmacy and Technology. 2022; 15(2):736-0. doi: 10.52711/0974-360X.2022.00122 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2022-15-2-42
REFERENCES:
1. Clarke S, Foster J. A history of blood glucose meters and their role in self-monitoring of diabetes mellitus. British Journal of Biomedical Science. 2012;69(2):83-93. doi: 10.1080/09674845.2012.12002443
2. Mergenthaler P, Lindauer U, et al. Sugar for the brain: the role of glucose in physiological and pathological brain function. Trends in Neurosciences. 2013;36(10):587-97. doi:10.1016/j.tins.2013.07.001
3. Meigs JB, Wilson PW, et al. Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease. The Journal of Clinical Endocrinology & Metabolism. 2006;91(8):2906-12. doi: 10.1210/jc.2006-0594
4. Benton D, Parker PY. Breakfast, blood glucose, and cognition. The American Journal of Clinical Nutrition. 1998;67(4):772S-8S. doi: 10.1093/ajcn/67.4.772S
5. Kalra S, Sharma SK. Diabetes in the Elderly. Diabetes Therapy. 2018;9(2):493-500. doi: 10.1007/s13300-018-0380-x
6. Lewis MT, Lujan HL,et al. Obesity and inactivity, not hyperglycemia, cause exercise intolerance in individuals with type 2 diabetes: Solving the obesity and inactivity versus hyperglycemia causality dilemma. Medical Hypotheses. 2019;123:110-4. doi: 10.1016/j.mehy.2019.01.013
7. Masih J, Bansal A, Amit TK, Painkara U. Epidemiological Profile of Diabetics. Research Journal of Pharmacology and Pharmacodynamics. 2013;5(3):4.
8. Seidemann J. World spice plants: economic usage, botany, taxonomy: Springer Science and Business Media; 2005.
9. Laribi B, Kouki K, et al. Coriander (Coriandrum sativum L.) and its bioactive constituents. Fitoterapia. 2015;103:9-26. doi: 10.1016/j.fitote.2015.03.012
10. Gil A, De La Fuente EB, et al. Coriander essential oil composition from two genotypes grown in different environmental conditions. Journal of Agricultural and Food Chemistry. 2002;50(10):2870-7. doi: 10.1021/jf011128i
11. Al-Rowais NA. Herbal medicine in the treatment of diabetes mellitus. Saudi Medical Journal. 2002;23(11):1327-31.
12. Otoom S, Al-Safi S,et al. The use of medicinal herbs by diabetic Jordanian patients. Journal of Herbal Pharmacotherapy. 2006; 6(2): 31-41. doi: 10.1300/J157v06n02_03
13. Lal A, Kumar T, et al. Hypolipidemic effect of Coriandrum sativum L. in triton-induced hyperlipidemic rats. 2004.
14. Momin AH, Acharya SS, et al. Coriandrum sativum-review of advances in phytopharmacology. International Journal of Pharmaceutical Sciences and Research. 2012;3(5):1233. doi: 10.13040/IJPSR.0975-8232.3(5).1233-39
15. Bhat S, Kaushal P, et al. Coriander (Coriandrum sativum L.): Processing, nutritional and functional aspects. African Journal of Plant Science. 2014;8(1):25-33. doi: 10.5897/AJPS2013.1118
16. Sureshkumar C, Meera R, et al. Antinociceptive, Anti-inflammatory activity of Coriander sativum Leaves. Research Journal of Pharmacy and Technology. 2010;3(3):744-7.
17. Sundar S, Padmalatha K, et al. Anti-microbial Activity of Aqueous Extract of Natural Preservatives-Cumin, Cinnamon, Coriander and Mint. Asian Journal of Research in Chemistry. 2016; 9(7):843.
18. Kaur M, Sidhu GK. A Pre-experimental Study to Assess the Effectiveness of Coriander Seeds Water on Leucorrhoea among Women (15–45 years) residing in selected Rural Areas of District Ludhiana (Punjab). International Journal of Nursing Education and Research. 2017; 5(3): 263-8. doi: 10.5958/2454-2660.2017.0
19. Kunzemann J, Herrmann K. Isolation and identification of flavon (ol)-O-glycosides in caraway (Carum carvi L.), fennel (Foeniculum vulgare Mill.), anise (Pimpinella anisum L.), and coriander (Coriandrum sativum L.), and of flavon-C-glycosides in anise. I. Phenolics of spices (author's transl). Zeitschrift fur Lebensmittel-untersuchung und-Forschung. 1977;164(3):194-200. doi: 10.1007/BF01263030.
20. Zheljazkov VD, Pickett KM, et al. Cultivar and sowing date effects on seed yield and oil composition of coriander in Atlantic Canada. Industrial Crops and Products. 2008;28(1):88-94. doi: 10.1016/j.indcrop.2008.01.011
21. Matos MJ, et al. Coumarins—an important class of phytochemicals. Phytochemicals-isolation, characterisation and role in human Health. 2015:113-40. doi: 10.5772/59982
22. Saifi A, Chauhan R, et al. Development of a polyherbal formulation FMST and evaluation for antidiabetic activity in alloxan induced diabetic rats. Asian Journal of Pharmaceutical Research. 2017;7(1):01-7. doi: 10.5958/2231-5691.2017.00001.6
23. Control Naodaf. Peraturan Badan Pengawas Obat dan Makanan Nomor 32 tahun 2019 tentang Persyaratan Keamanan dan Mutu Obat Tradisional. In: National Agency of Drug and Food Control I, Editor. 2019.
24. Huber L, Gillespie T. Modeling leaf wetness in relation to plant disease epidemiology. Annual review of phytopathology. 1992;30(1):553-77. doi: 10.1146/annurev.py.30.090192.003005
25. Beyzi E, Karaman K,et al. Change in some biochemical and bioactive properties and essential oil composition of coriander seed (Coriandrum sativum L.) varieties from Turkey. Industrial Crops and Products. 2017;109:74-8.
26. Ludwiczuk A, Skalicka-Woźniak K,et al. Terpenoids. Pharmacognosy: Elsevier; 2017. p. 233-66.
27. Lawrence B, Reynolds R. Progress in Essential Oils em Perfumer & Flavorist. Allures Bussiness Media Carol Stream; 2000.
28. Sharma M, Sharma R. Coriander. Handbook of Herbs and Spices: Elsevier; 2012. p. 216-49.
29. Illés V, Daood H,et al. Extraction of coriander seed oil by CO2 and propane at super-and subcritical conditions. The Journal of Supercritical Fluids. 2000;17(2):177-86. doi: 10.1016/S0896-8446(99)00049-2
30. Sogara PPU. Pengaruh ekstrak etanol buah ketumbar (coriandrum sativum l.) Terhadap penurunan kadar gula darah tikus putih yang diinduksi aloksan. Pharmacon. 2014; 3(3). doi: 10.35799/pha.3.2014.5417
31. Handayani PA, Juniarti ER. Ekstraksi minyak ketumbar (coriander oil) dengan pelarut etanol dan N-heksana. Jurnal Bahan Alam Terbarukan. 2012;1(1). doi: 10.15294/jbat.v1i1.2538
32. Elliott BD, Langer O,et al. Insignificant transfer of glyburide occurs across the human placenta. American Journal of Obstetrics and Gynecology. 1991;165(4):807-12. doi: 10.1016/0002-9378(91)90421-m
33. Koren G. Glyburide and fetal safety; transplacental pharmacokinetic considerations. Reproductive Toxicology. 2001;15(3):227-9. doi: 10.1016/s0890-6238(01)00122-8
34. Nitin M, Firdous A,et al. Pharmacodynamic Drug Interaction of Ethionamide with Glibenclamide in Normal and Diabetic Rats. Research journal of Pharmacology and Pharmacodynamics. 2013;5(4):IV.
35. Nazira S, Thadeus MS, et al. Uji efektivitas ekstrak biji ketumbar (Coriandrum sativum l.) terhadap gambaran histopatologi ginjal tikus hiperkolesterolemia diabetes. Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan. 2020;4(2):357-68. doi: 10.24912/jmstkik.v4i2.8249
36. Franz MJ, Bantle JP, et al. Evidence-based nutrition principles and recommendations for the treatment and prevention of diabetes and related complications. Diabetes Care. 2002;25(1):148-98. doi: 10.2337/diacare.26.2007.s51
37. Sharma D, Prashar D, et al. Bird’s Eye View on Herbal Treatment of Diabetes. Asian Journal of Pharmaceutical Research. 2012;2(1):1-6.
38. Dattatraya SK, Dattatray SK, et al. Formulation and Evaluation of Herbal Antidiabetic Tablet. Asian Journal of Research in Pharmaceutical Sciences. 2020;10(3):145-8. doi: 10.22270/jddt.v1i1.24
39. Pawar M, Patil N, et al. Anti-diabetic uses of some Common Herbs in Pastoral Region of Dhule District of Maharashtra. Research Journal of Pharmaceutical Dosage Forms and Technology. 2013;5(2):62-4.
40. Raju K, Rose AS, et al. Formulation and evaluation of anti diabetic herbal syrup. In vitro. 2020;3:w2. doi: 10.5958/0975-4385.2020.00023.0