Author(s): Nanda Rachmad Putra Gofur, Aisyah Rachmadani Putri Gofur, Rizki Nur Rachman Putra Gofur, Mega Kahdina, Hernalia Martadila Putri, Soesilaningtyas


DOI: 10.52711/0974-360X.2022.00151   

Address: Nanda Rachmad Putra Gofur1, Aisyah Rachmadani Putri Gofur2, Rizki Nur Rachman Putra Gofur3, Mega Kahdina3, Hernalia Martadila Putri2, Soesilaningtyas4
1Department of Health, Faculty of Vocational Studies, Universitas Airlangga, Indonesia.
2Narizma Healthcare, Surabaya, Indonesia.
3HVA Hospital, Pare Kediri, East Java.
4Deptartment of Dental Nursing, Politeknik Kesehatan Kementrian Kesehatan, Indonesia.
*Corresponding Author

Published In:   Volume - 15,      Issue - 2,     Year - 2022

Background: Lichenoid reaction as the result of hypersensitivity from drug might be had similir clinical appearance to idiopathic lichen planus. Lichenoid drug reaction is termed as a condition of the oral cavity having an identifiable etiology, which is clinically and histologically similar to oral lichen planus and also manifest on genital. A number of drugs have been described as a causative factor of those reactive lesions. Objectives : The aim of this study is to finding mechanism of oral-genital lichenoid reaction caused by drugs. Problem Statement: Potential Pathway of Oral-genital lichenoid reaction caused by drugs. Discussion: Oral lichenoid lesions could be impact from medication and contact antigenic reaction. Clinical condition these two look similar to oral lichen planus, also its pathology. Studies of LDR caused by angiotensin-converting enzyme (ACE) inhibitors, antimalaria, antituberculosis, antitumor and non-steroidal anti-inflammatory drugs (NSAIDs) have been found. Conclusion: OLR is a disease condition with definite identifiable aetiology. Cell-mediated immune dysregulation has been associated with pathogenesis, explaining oral and genital manifestation.

Cite this article:
Nanda Rachmad Putra Gofur, Aisyah Rachmadani Putri Gofur, Rizki Nur Rachman Putra Gofur, Mega Kahdina, Hernalia Martadila Putri, Soesilaningtyas. Oral-Genital Lichenoid Reaction: A Rare Hypersensitives to Drug, A Review. Research Journal of Pharmacy and Technology. 2022; 15(2):903-7. doi: 10.52711/0974-360X.2022.00151

Nanda Rachmad Putra Gofur, Aisyah Rachmadani Putri Gofur, Rizki Nur Rachman Putra Gofur, Mega Kahdina, Hernalia Martadila Putri, Soesilaningtyas. Oral-Genital Lichenoid Reaction: A Rare Hypersensitives to Drug, A Review. Research Journal of Pharmacy and Technology. 2022; 15(2):903-7. doi: 10.52711/0974-360X.2022.00151   Available on:

1.    Schmouchkovitch A, Herry H, Thuillier P, Kerlan V, Fleuret C, Le Toux G, et al. 2017. Oral and vulvo-vaginal lichenoid reactions due to mitotane (Lysodren): A case report. Medicine (Baltimore) 2017;96:e5075.
2.    Sarode SC, Sarode GS, Kalele K. 2012. Oral lichenoid reaction: A review. Int J Oral Maxillofac Pathol 2012;3:17-26
3.    A. Tamil Selvan, C. Jothibaskara Mohan, S. Karpagam Kumara Sundari, R. Suthakaran. Study on Role of Postmarketing Surveillance in New Drug Development. Asian J. Management 4(1): Jan.-Mar. 2013 page 12-15
4.    Evaluation of plasma drug concentration of Vasavaleha. Asian J. Pharm. Ana. 3(1): Jan.-Mar. 2013; Page 01-02.
5.    Nagaraj T, Saxena S, Nigam H, Biswas A, Sahu P. 2018. Oral lichenoid reaction on right buccal mucosa: A case report. J Adv Clin Res Insights 2018;5:56-57
6.    Kamath VV, Setlur K, Yerlagudda K. 2015. Oral lichenoid lesions - a review and update. Indian J Dermatol. Jan-Feb;60(1):102. doi: 10.4103/0019-5154.147830. PMID: 25657414; PMCID: PMC4318020.
7.    Sushil D. Patil, Prajkta Varpe, Sayali Chaure, Sanjay Kshirsagar. Comparison Study of Conventional and Microwave Assisted Force Degradation by RP-HPLC Method of Pharmaceutical Drug and Dosage form. Asian J. Pharm. Ana. 2017; 7(4): 218-224.
8.    P Ravi Kumar, Y Padmavathi , P Niveditha , N. Raghavendra Babu.. Development and Validation of Difference Spectrophotometric Method for the Quantitative Estimation of Mesalamine in Bulk Drug and Dosage forms. Asian J. Pharm. Ana. 2017; 7(4): 225-228.
9.    Ismail SB, Kumar KS, Zain RB. 2007. Oral lichen planus and lichenoid reactions: etiopathogenesis, diagnosis, management and malignant transformation. J Oral Sci 2007;49:89- 106
10.    Bäckman K, Jontell M. 2007. Microbial-associated oral lichenoid reactions. Oral Dis 2007;13:402-6
11.    Santosh V. Gandhi, Parag L. Khairnar1, Atul P. Chaudhari. Application of Multivariate Calibration Methods for Simultaneous Determination of Drugs in Fixed Dose Combination.Asian J. Pharm. Ana. 2018; 8(1):01-06
12.    Tomasz W. Kamiński, Małgorzata Karbowska, Dariusz Pawlak. A Review of the Pharmacological properties of potential drugs for the treatment of stuttering from the past to the future. Asian J. Pharm. Res. 2018; 8(2):104-109.
13.    Sugerman PB, Savage NW, Walsh LJ, Zhao ZZ, Zhou XJ, Khan A, Seymour GJ, Bigby M. 2002. The pathogenesis of oral lichen planus. Crit Rev Oral Biol Med 13, 350-365.
14.    Amy DPD, Akram Shalabi, Ori Finfter, Yonatan Birenzweig, Yehuda Zadik. 2020. Severe chronic nonlichenoid oral mucositis in pembrolizumab-treated patients: new cases and a review of the literature, Immunotherapy, 10.2217/imt-2019-0162, (2020).
15.    Saurat, J.-H.; Lipsker, D.; Thomas, L.; Borradori, L.; Lachapelle, J.-M. 2017. Dermatologie Et Infections Sexuellement Transmissibles, 6th ed.; Elsevier-Masson: Paris, France.
16.    Lombardi, T.; Küffer, R. 2016.  Concept actuel du lichen plan oral. Le diagnostic facile au début, peut devenir très difficile dans les lichens anciens. La Presse Médicale 2016, 45, 227–239
17.    Guggina LM, Yanes DA, Choi JN. 2017. Inverse lichenoid drug eruption associated with nivolumab. JAAD Case Rep 2017;3:7-9.
18.    Giuliani, M.; Troiano, G.; Cordaro, M.; Corsalini, M.; Gioco, G.; Muzio, L.L.; Pignatelli, P.; Lajolo, C. 2019. Rate of malignant transformation of oral lichen planus: A systematic review. Oral Dis. 2019, 25, 693–709
19.    Helen McParland and Saman Warnakulasuriya. 2012. “Oral Lichenoid Contact Lesions to Mercury and Dental Amalgam—A Review,” Journal of Biomedicine and Biotechnology, vol. 2012, Article ID 589569, 8 pages.
20.    Sachin C Sarode, Gargi S Sarode, Ketki Kalele. 2012. Oral Lichenoid Reaction: A Review. International Journal of Oral and Maxillofacial Pathology; 2012:3(4):17-26.
21.    Moraes PC, Noce CW, Thomaz LA, Cintra ML, Correa ME. 2011. Pigmented lichenoid drug eruption secondary to chloroquine therapy: An unusual presentation in lower lip. Minerva Stomatol 2011;60:327-32.  
22.    Postlewait LM, Ethun CG, Tran TB, et al. 2016. Outcomes of adjuvant mitotane after resection of adrenocortical carcinoma: a 13-institution study by the US Adrenocortical Carcinoma Group. J Am Coll Surg 2016;222:480–90.
23.    Sciubba JJ. 2011. Autoimmune oral mucosal disease. Dent Clint North Am. 2011;5(1): 89-103
24.    Handono K, Gofur NRP, Nurdiana N, Kalim H. 2020. Gingivitis on Systemic Lupus Erythematosus (SLE) patients: A Pilot study Research J. Pharm. and Tech. 2020; 13(11):5466-5470. DOI: 10.5958/0974-360X.2020.00954.3
25.    Gofur NRP, Handono K, Nurdiana N, Kalim H. 2020. Association of Th – Tc Protein CD28+ and Periodontal Inflammation among Indonesian Women with SLE Disease. Sys Rev Pharm 2020; 11(6): 580 586
26.    Gofur NRP. 2020 Impact of SARS-CoV-2 on periodontal tissue manifestation. J Int Oral Health 2020;12:S90-2.
27.    Gofur NRP, Handono K, Nurdiana N and Kalim H. Periodontitis is associated with disease severity and anti-double stranded DNA antibody and interferon-gamma levels in patients with systemic lupus erythematosus, Journal of Taibah University Medical Sciences, 2019; 21;14(6):560-565.
28.    Van der Meij E H, Schepman K P, Van der Waal I. 2003. The possible premalignant character of oral lichen planus and oral lichenoid lesions – A prospective study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003; 96: 164–171.
29.    Manohar D. Kengar, Kiran K. Patole, Akshay K. Ade, Sumesh M. Kumbhar, Chetan D. Patil, Ashutosh R. Ganjave. Introduction to Pharmacovigilance and Monitoring. Asian J. Pharm. Res. 2019; 9(2): 116-122.
30.    Al-Hashimi I, Schifter M, Lockhart PB, Wray D, Brennan M, Migliorati CA, et al. 2007. Oral lichen planus and oral lichenoid lesions: Diagnostic and therapeutic considerations. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;103:1-12.  
31.    Dudhia BB, Dudhia SB, Patel PS, Jani YV. Oral lichen planus to oral lichenoid lesions: Evolution or revolution. J Oral Maxillofac Pathol [serial online] 2015 [cited 2019 Nov 22];19:364-70. Available from:
32.    Hirota SK, et al. 2011. Analysis of a possible association between oral lichen planus and drug intake. A control study. Med Oral Patol Oral Cir Bucal 2011;16:e750–6.
33.    Akshay R. Yadav, Shrinivas K. Mohite. Cancer- A Silent Killer: An Overview. Asian J. Pharm. Res. 2020; 10(3):213-216.
34.    Sarika V. Khandbahale. A Review- Nanosuspension Technology in Drug Delivery System. Asian J. Pharm. Res. 2019; 9(2): 130-138.
35.    Sarika S. Lokhande. Microemulsions as Promising Delivery Systems: A Review. Asian J. Pharm. Res. 2019; 9(2): 90-96.
36.    Manisha Dhondising Rajput, Y. B. Rajput, L. D. Rajput. A Review on Adverse Drug Reaction. Asian J. Pharm. Res. 2020; 10(3):221-225.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Recent Articles


Not Available