ABSTRACT:
The occurrence of diverse secondary metabolites have been reported from different species of Drymaria. The present study was carried out to identify the bio compounds that are present in the ethanolic extract of Drymaria cordata an ethno medicinal plant by GC-MS analysis and to ascertain its utility by the local tribes as a plant possessing medicinal properties. Nine bioactive compounds were identified. The major compounds are 1,2-Benzenedicarboxylicacid, diisooctylester (46.88%), 1,8-Octanediol (31.25%), Myo-Inosito1, 4-C-methy1- (7.81%) and 2-Octen-1-ol (7.81%) along with few minor compounds. These bioactive compounds are known to possess various properties that are of pharmacological significance and can be harnessed for human benefits.
Cite this article:
Indira M. N. GC-MS Analysis of bioactive compounds in Ethanolic extract of Drymaria cordata (L.) Willd. ex Roem. and Schult. Research Journal of Pharmacy and Technology. 2022; 15(9):4192-5. doi: 10.52711/0974-360X.2022.00703
Cite(Electronic):
Indira M. N. GC-MS Analysis of bioactive compounds in Ethanolic extract of Drymaria cordata (L.) Willd. ex Roem. and Schult. Research Journal of Pharmacy and Technology. 2022; 15(9):4192-5. doi: 10.52711/0974-360X.2022.00703 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2022-15-9-63
REFERENCES:
1. Ullah R. Alqahtani AS. Noman OMA. Alqahtani AM. Ibenmoussa S. Bourhia M. A review on ethno-medicinal plants used in traditional medicine in the Kingdom of Saudi Arabia. Saudi Journal of Biological Sciences. 2020; 27(10):2706-2718. https://doi.org/10.1016/j.sjbs.2020.06.020
2. Suntar, I. Importance of ethnopharmacological studies in drug discovery: role of medicinal plants. Phytochemistry Reviews. 2020; 19. https://doi.org/10.1007/s11101-019-09629-9
3. Hsieh PW. Chang FR. Yen HF. Wu YC. Anemonin and twonorsesquiterpenes from Drymaria diandra. Biochemical Systematics and Ecology. 2003; 31:541-543. http://dx.doi.org/10.1016/S0305-1978(02)00182-5
4. Dominguez XA. Marroquin J. Gutierrez M. Triterpene acetates and D-(+)-Pinitol from Drymaria drumondii. Phytochemistry. 1975; 14:815-816. DOI: 10.1016/0031-9422(75)83046-9
5. Vargas D. Dominguez XA. Askar KA. Gutierrez M. Hostettmann K. Norditerpenes and norditerpene glycosides from Drymaria arenarioides. Phytochemistry. 1988; 27(5):1532-1534. https://doi.org/10.1016/0031-9422(88)80233-4
6. Indira MN. Tejavathi DH. Growth Response of in vitro regenerated Drymaria cordata (L.) Willd. Ex Roem. and Schult. to inoculation with Arbuscular Mycorrhizal fungi. 2021; 15(5): 452-458. doi.org/10.5530/ctbp.2021.3s.39
7. Akindele AJ. Ibe IF. Adeyemi OO. Analgesic and antipyretic activities of Drymaria cordata (Linn.) Willd (Caryophyllaceae) extract. African Journal of Traditional Complementary and Alternative Medicine. 2012; 9(1): 25-35. http://dx.doi.org/10.4314/ajtcam.v9i1.4
8. Balangcod TD. Balangcod AKD. Ethnomedical knowledge of plants and healthcare practices among the Kalanguya tribe in Tinoc, Ifugao, Luzon, Philippines. Indian Journal of Traditional Knowledge. 2011; 10(2):227-238.
9. Adeyemi OO. Akindele AJ. Ndubuisi N. Anti-inflammatory activity of Drymaria cordata extract. Journal of Natural Remedies. 2008; 8(1):93-100. doi:10.18311/jnr/2008/303
10. Dutta U. Sarma GC. Medicinal plants used by the local fringe communities of Chirang Reserve Forest, BTAD, Assam. Indian Journal of Research. 2013; 2(2):262-265. doi:10.15373/22501991/FEB2013/95
11. Veitch NC. Grayer RJ. Flavonoids and their glycosides, including anthocyanins. Natural Products Reports. 2008; 25:555-611. doi: 10.1039/b718040n
12. Hsieh PW. Chang FR. Lee KH. Hwang TL. Chang SM. Wu YC. A new anti-HIV alkaloid, Drymaritin, and a new C-glycoside flavonoid, diandraflavone, from Drymaria diandra. Journal of Natural Products. 2004; 67(7):1175-1177. http://dx.doi.org/10.1021/np0400196
13. Wetzel I. Allmendinger L. Bracher F. Revised structure of the alkaloid Drymaritin. Journal of Natural Products. 2009; 72(10):1908-10. doi: 10.1021/np900515b
14. Ding Z. Zhou J. Tan N. Teng R. Two new cyclic peptides from Drymaria diandra. Planta Medica.2000; 66(4):386-8. doi: 10.1055/s-2000-8543
15. Bhattacharyya R. Medhi KK. Borkataki S. Phytochemical analysis of Drymaria cordata (L.) Willd. Ex Schult. (Whole plant) used by tea tribes of erstwhile Nagaon district of Assam, India. International Journal of Pharmaceutical Sciences and Research. 2019; 10(9):4264-69. doi:10.13040/IJPSR.0975-8232.
16. Kafle S. Basnyat R. Rajbhandari M. Phytochemical analysis, antioxidant, antimicrobial activities and GC-MS profiling of Drymaria Diandra Blume. Scientific World. 2021; 14(14):90-98. https://doi.org/10.3126/sw.v14i14.35000
17. Mukherjee PK. Bhattacharya S. Saha K. Giri SN. Pal M. Saha BP. Antibacterial evaluation of Drymaria cordata Willd. (Family-Caryophyllaceae) extract. Phytotherapy Research. 1997; 11:249-250. http://dx.doi.org/10.1002/(SICI)1099-1573(199705)11:3<249::AID-PTR69>3.0.CO;2-W
18. Barua CC. Roy JD. Buragohain B. Barua AG, Borah P and Lahkar M. Analgesic and anti-nociceptive activity of hydroethanolic extract of Drymaria cordata Willd. Indian Journal of Pharmacology. 2011; 43(2):121-5. https://www.ijp-online.com/text.asp?2011/43/2/121/77337
19. Mukherjee PK. Saha K. Bhattacharya S. Giri SN. Pal M. Saha BP. Studies on antitussive activity of Drymaria cordata Willd. (Caryophyllaceae). Journal of Ethnopharmacology. 1997; 56:77-80. http://dx.doi.org/10.1016/S0378-8741(97)01512-2
20. Barua CC. Roy JD. Buragohain B. Talukdar A. Barua AG. Borah P. Lahkar M. CNS depressant and anti- convulsant activity of hydroethanolic extract of Drymaria cordata Willd. Journal of Veterinary Pharmacology and Toxicology. 2012; 11(1-2):8-12.
21. Singh. S. Chakaraborthy GS. Evaluation of Anti-asthmatic and Antioxidant potentials of seed extract of Strychnos nux vomica L. Research J. Pharm. and Tech. 2020; 13(1): 114-118. doi: 10.5958/0974-360X.2020.00023.2
22. Vignesh Balaji. E, Tamil Selvan. A, Srinivasan. A, Nandhini. S. Punica granatum root (s): Phytocompounds analysis, anti-oxidant and anti-microbial activity. Asian J. Pharm. Ana. 2019; 9(3):123-127. doi: 10.5958/2231-5675.2019.00023.1
23. Saha D. Paul S. Pharmacognostic studies of aerial part of methanolic extract of Tridax procumbens. Asian J. Pharm. Tech. 2012; 2(3): 107-109.
24. Khan MY. Aziz I. Ahmad I. Roy M. Verma VK. A natural cure to arthritis by phytomedicines – A review. Asian J. Res. Pharm. Sci. 2015; 5(4): 216-220. doi: 10.5958/2231-5659.2015.00031.4
25. Rahman MS. Anwar MN. Fungitoxic and cytotoxic activity of a novel compound 1,2-benzenedicarboxylic acid, diisooctyl ester of Plumbago zeylanica Linn. Asian Journal of Microbiology, Biotechnology and Environmental Sciences. 2006; 8(3): 461-464.
26. Shettima AY. Karumi Y. Sodipo OA. Usman H. Tijjani MA. Gas Chromatography–Mass Spectrometry (GC-MS) Analysis of bioactive components of ethyl acetate root extract of Guiera senegalensis J.F. Gmel. Journal of Applied Pharmaceutical Science. 2013; 3(03):146-150. doi: 10.7324/JAPS.2013.30328
27. Tangavelou AC. Viswanathan MB. Balakrishna K. Patra A. Phytochemical analysis in the leaves of Chamaecrista nigricans (Leguminosae). Pharmaceutica Analytica Acta. 2018; 9(3):582. doi: 10.4172/2153-2435.1000582
28. Caputo M. Bona E. Leone I. Samà MT. Nuzzo A. Ferrero A. Aimaretti G. Marzullo P. Prodam F. Inositols and metabolic disorders: From farm to bedside. Journal of Traditional and Complementary Medicine. 2020; 10(3):252-259. doi: 10.1016/j.jtcme.2020.03.005
29. PubChem Compound Summary for CID 5318599, trans-2-Octen-1-Ol. National Center for Biotechnology Information. 2021. https://pubchem.ncbi.nlm.nih.gov/compound/trans-2-Octen-1-Ol.
30. Zawirska-Wojtasiak R. Jankowska B. Piechowska P. Mildner-Szkudlarz S. Vitamin C and aroma composition of fresh leaves from Kalanchoe pinnata and Kalanchoe daigremontiana. Scientific Reports. 2019; 9:19786. https://doi.org/10.1038/s41598-019-56359-1
31. Mihailovi V. Vukovi N. Niiforovi N. Soluji S. Mladenovi M. Maškovi P. Stankovi MS. Studies on the antimicrobial activity and chemical composition of the essential oils and alcoholic extracts of Gentiana asclepiadea L. Journal of Medicinal Plants Research. 2011; 5(7):1164-1174.
32. Chachaiya PK. Mehta G. Evaluation of secondary metabolites in wheat grain (Triticum Sp.) grown in humid south eastern plain zone of Rajasthan (India). International Journal of Agriculture, Environment and Biotechnology. 2019; 12(3):249-260. doi: 10.30954/0974-1712.08.2019.8
33. Kiruthika KA. Sornaraj R. Screening of bioactive components of the flower Datura metel using the GC-MS technology. International Journal of Pharm Tech Research. 2011; 3(4):2025-2028.
34. Olowofolahan AO. Oyebode OT. Olorunsogo OO. GCMS analysis of partially purified chloroform sub fractions of methanol extract of Drymaria cordata (Linn) and their effects on mitochondrial membrane permeability transition pore. Archives of Basic and Applied Medicine. 2020; 8:3-11.
35. Kolhe RC. Chaudhari RY. A review of phytopharmacological profile of traditionally used medicinal plant Parkia biglandulosa (Mimosaceae). Asian Journal of Pharmaceutical Research. 2020; 10(1):34-38. doi: 10.5958/2231-5691.2020.00008.8
36. Indriati DW. Tumewu L. Widyawaruyanti A. Khairunisa SQ. The activities of methanol extract, hexane and ethyl acetate fractions from Ficus fistulosa in HIV inhibition in vitro. Research J. Pharm. and Tech. 2020; 13(1): 187-190. doi: 10.5958/0974-360X.2020.00038.4
37. Sonawane S. Bharati D. Undale VR. Bhosale AV. Central Nervous System depressant activity of ethanol extract of aerial parts of Cynodon dactylon (L.) Pers. (Durva) in mice. Research J. Pharmacognosy and Phytochemistry. 2009; 1(2): 119-122.
38. Gunasekaran B.Muralidharan P. Pandiselvi A. Amutha P. Preliminary phytochemical screening and antioxidant activities of ethanolic extract of Caesalpina sappan Linn. Research J. Pharm. and Tech. 2008; 1(3): 179-181.
39. Ramasubramaniaraja R. Pharmacognostical phytochemical including GC-MS investigation of ethanolic leaf extract of Abutilon indicum (Linn.). Asian J. Pharm. Ana. 2011; 1(4): 88-92.
40. Jenifer DR. Malathy BR. Jemmy C.H. In silico study of secondary metabolites from leaf extract of Plumbago zeylanica. Research J. Pharm. and Tech. 2020; 13(1): 86-90. doi: 10.5958/0974-360X.2020.00016.5
41. Jose BE, Panneerselvam P. Identification of phytochemical constituents within the Leaf extracts of Azima tetracantha Lam using Gas Chromatography-Mass Spectrometry Res. J. Pharmacology and Pharmacodynamics. 2019; 11(1):17-22. doi: 10.5958/2321-5836.2019.00004.1