Author(s):
Dipak Chandrakant Kulkarni, Anima Sunil Dadhich, Mukthinuthalapati Mathrusri Annapurna
Email(s):
adadhich@gitam.edu
DOI:
10.52711/0974-360X.2023.00797 
Address:
Dipak Chandrakant Kulkarni1, Anima Sunil Dadhich1*, Mukthinuthalapati Mathrusri Annapurna2
1Department of Chemistry, GITAM School of Science, Visakhapatnam, India.
2GITAM School of Pharmacy, GITAM (Deemed to be University), Visakhapatnam, India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 10,
Year - 2023
ABSTRACT:
The combination of Ezetimibe and Rosuvastatin is used for lowering the cholesterol along with proper diet. A new stability indicating RP-UFLC method has been developed and validated for the estimation of Ezetimibe and Rosuvastatin in tablet dosage forms. Shimadzu Model CBM-20A/20 Alite UFLC system with Phenomenex C18 column (PDA detector) was used for the present chromatographic study. Both the drugs obeyed Beer-Lambert’s law over the concentration range 0.1-150 mg/ml and the linear regression equations are found to be y = 43364x + 8195.5 and y = 49468x – 7194 (R² = 0.9999) (R² = 0.9999) Ezetimibe and Rosuvastatin respectively. The LOD and LOQ values were found to be 0.0287 mg/ml and 0.0957 mg/ml for Ezetimibe and for that of Rosuvastatin the LOD and LOQ values were found to be 0.0291 mg/ml and 0.0892 mg/ml for respectively. Stress degradation studies were performed and the method was validated as per ICH guidelines.
Cite this article:
Dipak Chandrakant Kulkarni, Anima Sunil Dadhich, Mukthinuthalapati Mathrusri Annapurna. A new stability indicating RP-UFLC method for the simultaneous estimation of Ezetimibe and Rosuvastatin combined dosage forms (Tablets). Research Journal of Pharmacy and Technology 2023; 16(10):4917-3. doi: 10.52711/0974-360X.2023.00797
Cite(Electronic):
Dipak Chandrakant Kulkarni, Anima Sunil Dadhich, Mukthinuthalapati Mathrusri Annapurna. A new stability indicating RP-UFLC method for the simultaneous estimation of Ezetimibe and Rosuvastatin combined dosage forms (Tablets). Research Journal of Pharmacy and Technology 2023; 16(10):4917-3. doi: 10.52711/0974-360X.2023.00797 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2023-16-10-67
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