Author(s):
Prafulla Tathe, Vaibhav P. Uplanchiwar, Sachin M. Hiradeve, Sushil Yadaorao Raut, Gayatri Katole, Mayuri Deshmukh, Namrata Mane, Vijendra B. Fulzele, Mohd. Hashim Mansoori
Email(s):
vaibhavuplanchiwar@gmail.com
DOI:
10.52711/0974-360X.2023.00799 
Address:
Prafulla Tathe1*, Vaibhav P. Uplanchiwar2, Sachin M. Hiradeve2, Sushil Yadaorao Raut4, Gayatri Katole2, Mayuri Deshmukh2, Namrata Mane2, Vijendra B. Fulzele3, Mohd. Hashim Mansoori3
1Research Scholar, Shri Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, Churu Rd, Vidyanagari, Churela - 333001, Rajasthan, India.
2Nagpur College of Pharmacy, Wanadongari, Hingna Road, Nagpur - 441110, Maharashtra, India.
3School of Pharmacy, G H Raisoni University, G H Raisoni Nagar, Saikheda, Dist: Chhindwara - 480106, Madhya Pradesh, India.
4Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research,
Sant Tukaram Nagar, Pimpri, Pune, Maharashtra, India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 10,
Year - 2023
ABSTRACT:
While dealing with the herbal drugs for various chaoses, flavonoids and saponin established their position and hepatoprotection is fine example among all health related issues. So, the study was executed taking into considerations of edible herbal constituents to check the potency of fruits extract of Sesbania grandiflora (FESG) on thioacetamide induced hepatotoxicity in experimental animals. In experimentation, the petroleum ether (PE) extracts at 100, 200 and 400mg/kg/p.o was fed to rats before intoxicated with thioacetamide (100 mg/kg). To check the efficacy of plant material, the diverse factors were assessed like SGOT, SGPT, SALP, bilirubin, protein, cholesterol, albumin and triglyceride and to confirm the study, liver histopathology was also determined. The obtained result parameters authenticated the strength of plant material via assessed factors with endorsement by histopathological study. The shielding outcome of this extract was due to the occurrence of phenol, flavonoids, and various antioxidants and due to existence of quercetin in it.
Cite this article:
Prafulla Tathe, Vaibhav P. Uplanchiwar, Sachin M. Hiradeve, Sushil Yadaorao Raut, Gayatri Katole, Mayuri Deshmukh, Namrata Mane, Vijendra B. Fulzele, Mohd. Hashim Mansoori. Assessment of Antihepatotoxic potential of Sesbania grandiflora fruits extract against Organosulfur compound- thioacetamide induced hepatopathy in experimental rodents. Research Journal of Pharmacy and Technology 2023; 16(10):4929-4. doi: 10.52711/0974-360X.2023.00799
Cite(Electronic):
Prafulla Tathe, Vaibhav P. Uplanchiwar, Sachin M. Hiradeve, Sushil Yadaorao Raut, Gayatri Katole, Mayuri Deshmukh, Namrata Mane, Vijendra B. Fulzele, Mohd. Hashim Mansoori. Assessment of Antihepatotoxic potential of Sesbania grandiflora fruits extract against Organosulfur compound- thioacetamide induced hepatopathy in experimental rodents. Research Journal of Pharmacy and Technology 2023; 16(10):4929-4. doi: 10.52711/0974-360X.2023.00799 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2023-16-10-69
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