Author(s): Vikram Kumar Sahu, Dewi Melani Hariyadi, Sribatsa Lanchhana Dash, Nitin Sharma, Ritu Karwasra

Email(s): vikramsahuknp@gmail.com

DOI: 10.52711/0974-360X.2023.00849   

Address: Vikram Kumar Sahu1*, Dewi Melani Hariyadi2, Sribatsa Lanchhana Dash3, Nitin Sharma4, Ritu Karwasra5
1Pharmaceutics Department, Maharana Pratap College of Pharmacy, Kanpur, India 209217.
2Pharmaceutics Department, Faculty of Pharmacy, Universitas Airlangga, Indonesia, 60115.
3Department of Pharmaceutical Sciences, Utkal University, Vani Vihar, Bhubaneswar - 751004, Odisha, India.
4Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Sector - 125, Noida, 201313, India.
5Central Council for Research in Unani Medicine, Ministry of AYUSH, Janakpuri, New Delhi, 11005 8, India.
*Corresponding Author

Published In:   Volume - 16,      Issue - 11,     Year - 2023


ABSTRACT:
Galantamine is a drug of choice for the treatment of Alzheimer's disease and possesses antioxidant, anti-inflammatory and cholinomimetic as non-FDA-approved indications. This study designed to explore the impact of Galantamine to attenuate cisplatin-induced neurotoxicity and oxidative stress. Experimental animals were segregated into five groups viz-a-viz group I as normal control, II as cisplatin control, and III-V as galantamine at varying doses, low (2.5mg/kg), medium (5mg/kg) and higher (10mg/kg). All the samples were orally administered, daily for 14 days. Cisplatin was injected intraperitoneally on day 8 to all groups except normal control. Assessment of neurotoxicity was done by measurement of a balance of antioxidant (GSH, SOD) and pro-oxidant (MDA), histopathological investigations. Dose-dependent significant (p<0.05) reduction in neurotoxicityhas been found by galantamine with reduction (p<0.01) in oxidant stress markers. Pronouncedreduction in apoptosis and elevation of disturbed hematological, and biochemical alterations were also observed with significance of p<0.001 in galantamine groups. We have observed that galantaminedose-dependentlyattenuates neurotoxicity, and oxidative stress, reversed the histopathological alterations and inhibits activated pro-inflammatory mediators (TNF-a). The research work provides drug repurposing of galantamine and providespreliminary ground for the treatment and management of cisplatin-induced neurotoxicity towards the clinical domain.


Cite this article:
Vikram Kumar Sahu, Dewi Melani Hariyadi, Sribatsa Lanchhana Dash, Nitin Sharma, Ritu Karwasra. Protective effect of Galantamine on attenuating Cisplatin-induced Neurotoxicity: An In-vitro and In-vivo approach. Research Journal of Pharmacy and Technology. 2023; 16(11):5239-4. doi: 10.52711/0974-360X.2023.00849

Cite(Electronic):
Vikram Kumar Sahu, Dewi Melani Hariyadi, Sribatsa Lanchhana Dash, Nitin Sharma, Ritu Karwasra. Protective effect of Galantamine on attenuating Cisplatin-induced Neurotoxicity: An In-vitro and In-vivo approach. Research Journal of Pharmacy and Technology. 2023; 16(11):5239-4. doi: 10.52711/0974-360X.2023.00849   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2023-16-11-43


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