Author(s): Jalaiah M., Jaya Sharma, Pankaj Sharma

Email(s): jali.pharma@gmail.com

DOI: 10.52711/0974-360X.2023.00111   

Address: Jalaiah M.1,2*, Jaya Sharma3, Pankaj Sharma4
1Research Scholar, Department of Pharmacology, Apex University, Jaipur - 303002, Rajasthan, India.
2Associate Professor, Department of Pharmacology, QIS College of Pharmacy, Ongole - 523001, Andhra Pradesh, India.
3Professor and Principal, Department of Pharmacy, Apex University, Jaipur - 303002, Rajasthan, India.
4Registrar and Dean, Department of Pharmacy, Apex University, Jaipur - 303002, Rajasthan, India.
*Corresponding Author

Published In:   Volume - 16,      Issue - 2,     Year - 2023


ABSTRACT:
Chemobrain is a typical adverse effect of chemotherapeutics agents that affects 15–80 percent of cancer patients. Doxorubicin, an antineoplastic drug, has been associated with severe neurotoxicity manifested as a loss in cognitive skills, most likely due to oxidative stress in brain. Krill oil (KO) is a unique, naturally occurring nutrient derived from a type of Antarctic krill, Euphausia superba that is commonly used as a dietary supplement and is well known for anti-inflammatory, hypolipidemic, anti-depressant and improvement of cognitive function, protection of neurodegeneration, neuroprotective and antioxidant qualities. The current study was aimed at evaluating krill oil's potential neuroprotection and memory improving benefits against Doxorubicin-induced cognitive and neurobiological defects. A novel object recognition task and Morris water maze test were conducted to evaluate the protective effect of krill oil against doxorubicin-induced memory deficits in rats. In female Wistar rats, cognitive impairment was produced by administering ten cycles of Doxorubicin (2.5mg/kg, intra peritoneal, once every five days). Krill oil (50mg/kg and 100mg/kg) was given orally starting one week prior to the doxorubicin treatment and continued throughout the study. Krill treatment (50mg/kg and 100mg/kg) significantly protected against Doxorubicin induced memory impairment. Co-administration of both doses of krill oil resulted in significantly lower the levels of tumour necrosis factor (TNFa), and acetyl cholinesterase activity. Furthermore, doxorubicin-induced oxidative and inflammatory insults in the frontal cortex and hippocampal areas of the brain were prevented by krill oil. In conclusion, krill oil may be a promising adjuvant treatment option for reducing adverse effects associated to doxorubicin treatment.


Cite this article:
Jalaiah M., Jaya Sharma, Pankaj Sharma. Krill Oil attenuates doxorubicin induced cognitive impairment by inhibiting oxidative stress markers in the brains of wistar rats. Research Journal of Pharmacy and Technology 2023; 16(2):652-8. doi: 10.52711/0974-360X.2023.00111

Cite(Electronic):
Jalaiah M., Jaya Sharma, Pankaj Sharma. Krill Oil attenuates doxorubicin induced cognitive impairment by inhibiting oxidative stress markers in the brains of wistar rats. Research Journal of Pharmacy and Technology 2023; 16(2):652-8. doi: 10.52711/0974-360X.2023.00111   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2023-16-2-30


REFERENCES:
1.    Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., and Jemal, A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians. 2018; 68(6): 394-424. doi.org/10.3322/ caac.21492.
2.    Siegel, R. L., Miller, K. D., and Jemal, A. Cancer statistics, 2019. CA: a cancer journal for clinicians. 2019; 69(1): 7-34. doi.org/10.3322/ caac.21565.
3.    Ahles, T. A., and Saykin, A. J. Breast cancer chemotherapy-related cognitive dysfunction. Clinical breast cancer. 2002; 3(3): S84-S90. doi.org/ 10.3816/CBC.2002.s.018
4.    Nelson, C. J., Nandy, N., and Roth, A. J. Chemotherapy and cognitive deficits: mechanisms, findings, and potential interventions. Palliative and supportive care. 2007; 5(3): 273-280. doi.org/10.1017/S1478951507000442
5.    Bender, C. M., Sereika, S. M., Berga, S. L., Vogel, V. G., Brufsky, A. M., Paraska, K. K., and Ryan, C. M. Cognitive impairment associated with adjuvant therapy in breast cancer. PsychoOncology. Journal of the Psychological, Social and Behavioral Dimensions of Cancer. 2006; 15(5): 422-430. doi.org/ 10.1002/pon.964
6.    Myers, J. S. The possible role of cytokines in chemotherapy-induced cognitive deficits. In Chemo Fog. 2010; (pp. 119-123): Springer, New York, NY.doi.org/ 10.1007/978-1-4419-6306-2_15
7.    Singal, P., Li, T., Kumar, D., Danelisen, I., and Iliskovic, N. Adriamycin-induced heart failure: mechanisms and modulation. Molecular and cellular biochemistry. 2000; 207(1-2): 77-86. doi.org/10.1023/A:1007094214460
8.    Kim, H. D., Lee, S. B., Ko, S. C., Jung, W. K., Kim, Y. M., and Kim, S. B. Anti-inflammatory effect of ozonated krill (Euphausia superba) oil in lipopolysaccharide-stimulated RAW 264.7 macrophages. Fisheries and Aquatic Sciences. 2018; 21(1): 15. doi.org/10.1186/s41240-018-0092-1
9.    Cicero, A. F., Rosticci, M., Morbini, M., Cagnati, M., Grandi, E., Parini, A., and Borghi, C. Lipid-lowering and anti-inflammatory effects of omega 3 ethyl esters and krill oil: a randomized, cross-over, clinical trial. Archives of medical science: AMS. 2016; 12(3): 507. doi: 10.5114/aoms.2016.59923
10.    Wibrand, K., Berge, K., Messaoudi, M., Duffaud, A., Panja, D., Bramham, C. R., and Burri, L. Enhanced cognitive function and antidepressant-like effects after krill oil supplementation in rats. Lipids in health and disease. 2013; 12(1): 6. doi.org/10.1186/ 1476-511X-12-6
11.    Burri, L. Krill oil supplementation and cognitive function. In Diet and Nutrition in Dementia and Cognitive Decline. 2015 Jan 1; (pp. 1031-1038). Academic Press. doi.org/10.1016/B978-0-12-407824-6.00096-3
12.    Mansour, S. Z., Moustafa, E. M., Hassan, A. A., and Thabet, N. M. Protective role of Krill oil against estrogen deficiency induced neurodegeneration in ovariectomized rats. Indian journal of experimental biology. 2017; 55: 279285. doi.org/nopr.niscair.res.in/handle/123456789/ 41727
13.    Jayanth P. C., Prasanna Kumar Kar, M. Niranjan Babu. Evaluation of Nootropic activity Potential of Krill Oil in Diazepam Induced Amnesic Mice. Research Journal of Pharmacology and Pharmacodynamics.2016; 8(3): 111-114.. doi: 10.5958/2321-5836.2016.00020.3
14.    Li, Q., Wu, F., Wen, M., Yanagita, T., Xue, C., Zhang, T., and Wang, Y. The Protective Effect of Antarctic Krill Oil on Cognitive Function by Inhibiting Oxidative Stress in the Brain of Senescence Accelerated Prone Mouse Strain 8 (SAMP8) Mice. Journal of food science. 2018; 83(2): 543-551. doi.org/10.1111/ 1750-3841.14044
15.    Shin, J. W., Seol, I. C., and Son, C. G. Interpretation of animal dose and human equivalent dose for drug development. The Journal of Korean Medicine. 2010; 31(3): 1-7. doi/koreascience.or.kr/article/ JAKO201025665646491
16.    Ramalingayya, G. V., Cheruku, S. P., Nayak, P. G., Kishore, A., Shenoy, R., Rao, C. M., and Krishnadas, N. Rutin protects against neuronal damage in vitro and ameliorates doxorubicin-induced memory deficits in vivo in Wistar rats. Drug design, development and therapy. 2017; 11: 1011. doi: 10.2147/DDDT.S103511
17.    Nagaraju B, Chandrasekhar K, Uma Sankar G, GSN Koteswarao, Umasankar K, A. Ankarao..Neuroprotective effect of Conessinin on Elevated oxidative stress induced Alzheimers’disease in rats. Research Journal of Pharmacy and Technology. 2020; 13(6): 2703-2707. doi: 10.5958/0974-360X.2020.00481.3
18.    Vaishali J. Mahadik, Monika N. Chavare, S. S. Patil, Kiran A. Wadkar. Cognition Enhancing potential of Sesbania grandiflora fruit extract in Scopolamine induced Amnesia in mice. Research Journal of Pharmacy and Technology. 2020; 13(11): 5057-5062. doi: 10.5958/0974-360X.2020.00886.0
19.    Moron MS, Depierre JW, Mannervik B. Levels of glutathione, gluta thione reductase and glutathione S-transferase activities in rat lung and liver. Biochim Biophys Acta. 1979; 582(1): 67–78. doi.org/10.1016/0304-4165(79)90289-7
20.    Misra HP, Fridovich I. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. Journal of Bio Chemistry. 1972; 247(10): 3170–3175. doi.org/10.1016/S0021-9258(19)45228-9
21.    Aebi H. Catalase. Methods in Enzymatic Analysis. New York, NY: Academic Press; 1974: 673–678. doi.org/10.1016/b978-0-12-091302-2.50032-3
22.    Pragati Khare, Kamal Kishore, Dinesh Kumar Sharma. Catalase and Superoxide Dismutase (SOD) activity in Swiss Albino mice treated with Ethanolic leaf extract of Bauhinia variegata. Research Journal of Pharmacy and Technology. 2019; 12(9): 4259-4262. doi:10.5958/0974-360X.2019.00732.7
23.    Sedlak J, Lindsay RH. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman’s reagent. Analytical Biochemistry. 1968; 25(1): 192–205. DOI: 10.1016/ 0003-2697(68)90092-4
24.    Christie LA, Acharya MM, Parihar VK, Nguyen A, Martirosian V, Limoli CL .Impaired cognitive function and hippocampal neurogenesis following cancer chemotherapy. Clinical Cancer Research. 2012; 18(7): 1954–1965. doi.org/10.1158/1078-0432.CCR-11- 2000
25.    Kitamura Y, Hattori S, Yoneda S et al. Doxorubicin and cyclophosphamide treatment produces anxiety-like behavior and spatial cognition impairment in rats: possible involvement of hippocampal neurogenesis via brain-derived neurotrophic factor and cyclin D1 regulation. Behavarial Brain Research. 2015; 292: 184–193. doi. org/10.1016/j.bbr.2015.06.007
26.    Hayslip J, Dressler EV, Weiss H et al. Plasma TNF-α and soluble TNF receptor levels after doxorubicin with or without coadministration of mesna—a randomized, cross-over clinical study. PLoS One. 2015 Apr 2014; 10(4): 1–14. doi.org/10.1371/ journal.pone. 0124988
27.    Aluise CD, Sultana R, Tangpong J et al .Chemo brain (chemo fog) as a potential side effect of doxorubicin administration: role of cytokine-induced, oxidative/nitrosative stress in cognitive dysfunction. Advances in Experimental Medical Biology. 2010; 147–156: doi.org/10.1007/978-1-4419-6306-2_19
28.    Keeney J. Doxorubicin-induced, TNF-α-mediated brain oxidative stress, neurochemical alterations, and cognitive decline: insights into mechanisms of chemotherapy induced cognitive impairment and its prevention. Theses and Dissertations--Chemistry. 2013. doi.uknowledge.uky.edu/ chemistry_etds/27
29.    Mohamed H. Sherif, Al-Shimaa M. Abas, Lobna A. Zaitoun. Ginger extract protect Iodinated Contrast Media Nephrotoxicity in rats through modulation of Oxidative Stress, Cystain C, NGAL and TNF α. Research Journal of Pharmacy and Technology 2018; 11(12): 5439-5448. doi: 10.5958/0974-360X.2018.00992.7
30.    Yamana Srikanth, T Tamilanban, V Chitra. Medicinal plants Targeting Alzheimer’s disease - A Review. Research Journal of Pharmacy and Technology. 2020; 13(7): 3454-3458. doi:10.5958/0974-360X.2020.00613.7
31.    Rahul P. Jadhav, Manohar D. Kengar, Omkar V. Narule, Vikranti W. Koli, Suraj B. Kumbhar. A Review on Alzheimer’s Disease (AD) and its Herbal Treatment of Alzheimer’s Disease. Asian Journal of Research in Pharmaceutical Sciences. 2019; 9(2): 112-122. doi: 10.5958/2231-5659.2019.00017.1
32.    Joshi G, Sultana R, Tangpong J et al. Free radical mediated oxidative stress and toxic side effects in brain induced by the anti-cancer drug adriamycin: insight into chemobrain. Free Radical Research. 2005; 39(11): 1147–1154. doi.org/10.1080/ 10715760500143478
33.    Shyamala Nayak, Nayanatara Arun Kumar, Anupama Hegde, Rekha D Kini, Vandana Blossom, Roopesh Poojary. Neuroprotective role of Allium cepa and Allium sativum on Hippocampus, striatum and Cerebral cortex in Wistar rats. Research Journal of Pharmacy and Technology. 2021; 14(5): 2406-1. doi: 10.52711/0974-360X.2021.00424
34.    Dose J, Matsugo S, Yokokawa H et al (2016) Free radical scavenging and cellular antioxidant properties of astaxanthin. International Journal of Molecular Science. 2016; 17(1). doi.org/10.3390/ijms17010103

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