Jalaiah M., Jaya Sharma, Pankaj Sharma
Jalaiah M.1,2*, Jaya Sharma3, Pankaj Sharma4
1Research Scholar, Department of Pharmacology, Apex University, Jaipur - 303002, Rajasthan, India.
2Associate Professor, Department of Pharmacology, QIS College of Pharmacy, Ongole - 523001, Andhra Pradesh, India.
3Professor and Principal, Department of Pharmacy, Apex University, Jaipur - 303002, Rajasthan, India.
4Registrar and Dean, Department of Pharmacy, Apex University, Jaipur - 303002, Rajasthan, India.
Volume - 16,
Issue - 2,
Year - 2023
Chemobrain is a typical adverse effect of chemotherapeutics agents that affects 15–80 percent of cancer patients. Doxorubicin, an antineoplastic drug, has been associated with severe neurotoxicity manifested as a loss in cognitive skills, most likely due to oxidative stress in brain. Krill oil (KO) is a unique, naturally occurring nutrient derived from a type of Antarctic krill, Euphausia superba that is commonly used as a dietary supplement and is well known for anti-inflammatory, hypolipidemic, anti-depressant and improvement of cognitive function, protection of neurodegeneration, neuroprotective and antioxidant qualities. The current study was aimed at evaluating krill oil's potential neuroprotection and memory improving benefits against Doxorubicin-induced cognitive and neurobiological defects. A novel object recognition task and Morris water maze test were conducted to evaluate the protective effect of krill oil against doxorubicin-induced memory deficits in rats. In female Wistar rats, cognitive impairment was produced by administering ten cycles of Doxorubicin (2.5mg/kg, intra peritoneal, once every five days). Krill oil (50mg/kg and 100mg/kg) was given orally starting one week prior to the doxorubicin treatment and continued throughout the study. Krill treatment (50mg/kg and 100mg/kg) significantly protected against Doxorubicin induced memory impairment. Co-administration of both doses of krill oil resulted in significantly lower the levels of tumour necrosis factor (TNFa), and acetyl cholinesterase activity. Furthermore, doxorubicin-induced oxidative and inflammatory insults in the frontal cortex and hippocampal areas of the brain were prevented by krill oil. In conclusion, krill oil may be a promising adjuvant treatment option for reducing adverse effects associated to doxorubicin treatment.
Cite this article:
Jalaiah M., Jaya Sharma, Pankaj Sharma. Krill Oil attenuates doxorubicin induced cognitive impairment by inhibiting oxidative stress markers in the brains of wistar rats. Research Journal of Pharmacy and Technology 2023; 16(2):652-8. doi: 10.52711/0974-360X.2023.00111
Jalaiah M., Jaya Sharma, Pankaj Sharma. Krill Oil attenuates doxorubicin induced cognitive impairment by inhibiting oxidative stress markers in the brains of wistar rats. Research Journal of Pharmacy and Technology 2023; 16(2):652-8. doi: 10.52711/0974-360X.2023.00111 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2023-16-2-30
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