Author(s): Ghufran Th. Sadeek, Zainab Faiyq Saeed, Mohanad Yakdhan Saleh


DOI: 10.52711/0974-360X.2023.00163   

Address: Ghufran Th. Sadeek1, Zainab Faiyq Saeed2, Mohanad Yakdhan Saleh1*
1Department of Chemistry, College of Education for Pure Science, University of Mosul. Mosul – Iraq.
2Department of Physiology, Biochemistry, and Pharmacology, College of Veterinary Medicine, University of Mosul.
*Corresponding Author

Published In:   Volume - 16,      Issue - 2,     Year - 2023

This class of compounds, which is known as Hydrazide has great significance in organic chemistry. This is the reason why methods of preparation of different types of compounds that are useful in many fields are studied here. It is characterized by containing an active group, which is (-CONHNH2), which consists of two nitrogen atoms attached to four substitutes, and at least one of these substitutes must be an (acyl) or (aryl) group. It is known that these compounds have very important medical, pharmaceutical and industrial functions and applications. Some of them have been employed in the treatment of many common and dangerous diseases, such as respiratory diseases and malaria. In addition, they are highly useful in preparing some important drugs used in the treatment of some chronic diseases related to blood vessels and muscle spasms, showing a wide variety of biological activities, including antibacterial, mitigating, anticonvulsant, antiviral, and antiprotozoal activity. Moreover, they may be used as raw materials in preparing many classes of heterocyclic compounds, including oxadiazole and diazole compounds. Finally, they show significance in industrial applications, particularly in the manufacture of dyes, agricultural pesticides, and growth stimulants for plants and Agricultural crops.

Cite this article:
Ghufran Th. Sadeek, Zainab Faiyq Saeed, Mohanad Yakdhan Saleh. Synthesis and Pharmacological Profile of Hydrazide Compounds. Research Journal of Pharmacy and Technology 2023; 16(2):975-2. doi: 10.52711/0974-360X.2023.00163

Ghufran Th. Sadeek, Zainab Faiyq Saeed, Mohanad Yakdhan Saleh. Synthesis and Pharmacological Profile of Hydrazide Compounds. Research Journal of Pharmacy and Technology 2023; 16(2):975-2. doi: 10.52711/0974-360X.2023.00163   Available on:

1.    Backes G.L.; Neumann D.M.; Jursic B.S. Synthesis and antifungal activity of substituted salicylaldehyde hydrazones, hydrazides, and sulfohydrazides. Bioorg. Med. Chem. 2014, 22, 4629-4636.
2.    Küçükgüzel S.G.; Mazi A.; Sahin F.; Öztürk S.; Stables J. Synthesis and biological activities of diflunisal hydrazide-hydrazones. Eur. J. Med. Chem. 2003, 38, 1005-1013.
3.    Popiołek Ł.; Biernasiuk A. Synthesis and investigation of antimicrobial activities of nitrofurazone analogs Containing hydrazide-hydrazone moiety. Saudi Pharm. J. 2017, 25, 1097-1102.
4.    Rollas S.; Gulerman N.; Erdeniz H. Synthesis and antimicrobial activity of some new hydrazones of 4-fluorobenzoic acid hydrazide and 3-acetyl-2, 5-disubstituted-1, 3,4-oxadiazolines. IL Farm. 2002, 57, 171-174.
5.    Nasr T.; Bondock S.; Youns M. Anticancer activity of new coumarins substituted hydrazide-hydrazine Derivatives. Eur. J. Med. Chem. 2014, 76, 539-548.
6.    He H.; Wang X.; Shi L.; Yin W.; Yang Z.; He H.; Liang Y. Synthesis, antitumor activity and mechanism of Action of novel 1, 3-thiazole derivatives containing hydrazide-hydrazone and carboxamide moiety. Bioorg. Med. Chem. Lett. 2016, 26, 3263-3270.
7.    Nasr T.; Bondock S.; Rashed H.M.; Fayad W.; Youns M.; Sakr T.M. Novel hydrazide-hydrazone and amide Substituted coumarins derivatives: Synthesis, cytotoxicity screening, microarray, radiolabeling and in vivo Pharmacokinetic studies. Eur. J. Med. Chem. 2018, 151, 723-739.
8.    Velezheva V.; Brennan P.; Ivanovo P.; Kornienko A.; Lyubimov S.; Kazarian K.; Nikonenko B.; Majorov K.; Apt A. Synthesis and ant tuberculosis activity of indole-pyridine derived hydrazides, hydrazide-hydrazones, And thiosemicarbazones. Bioorg. Med. Chem. Lett. 2016, 26, 978-985.
9.    Pavan F.R.; Maia P.I.S.; Leite S.R.A.; Deflon V.M.; Batista A.A.; Sato D.N.; Franzblau S.G.; Leite C.Q.F. Thiosemicarbazones, semicarbazones, dithiocarbazates and hydrazide/hydrazones: Anti-Mycobacterium Tuberculosis activity and cytotoxicity. Eur. J. Med. Chem. 2010, 45, 1898-1905.
10.    Bedia K.K.; Elçin O.; Seda U.; Fatma K.; Nathaly S.; Sevim R.; Dimoglo A. Synthesis and characterization of novel hydrazide-hydrazones and the study of their structure-ant tuberculosis activity. Eur. J. Med. Chem. 2006, 41, 1253-1261.
11.    Senkarde S.S.; Kaushik-Basu N.; Durmaz ˙I.; Manvar D.; Basu A.; Atalay R.; Küçükgüzel S.G. Synthesis Of novel diflunisal hydrazide-hydrazones as anti-hepatitis C virus agents and hepatocellular carcinoma Inhibitors. Eur. J. Med. Chem. 2016, 108, 301-308.
12.    Kratzl K. and Berger, "Zur synthesis alkylierter 1- phenyl hydrazine" Monatshefte fur chemie und verwandte teile anderer wissenschaften, vol. 107, No.5-8, pp.83-87, (1958).
13.    Katrizky A. R. Barczynski, and Ostercamp D. L., "Mechanisms of heterocycles ring formation .part 5.A carbon 13 nuclear magnatic resonance study pyrazolinone synthesis by the reaction of β -Ketoester with substituted hydrazine's." journal of the chemical society, Perkin transactions(1987), Vol. 2, No.8,p.969,
14.    Licandro E. and Perdicchia D. "N-acyl hydrazine future perspectives offered by new synthesis and chemistry, "European Journal of Organic Chemistry, No.4 p665-675, (2004).
15.    Smith R.F., Bates A.C., Battisti P.G., Byrnes C.T., Morz T. Smearing and Albrecht F.X., J. Org. Chem., vol. 33 No. 2 pp. 851-855 (1968).
16.    Smith P.A.S "The Curtius Reaction "in Orgaic Reactions, john wiley and Sons,Inc.,(2004).
17.    w.f.short J. Chem.Soc., vol.120.p., 1445(1921).
18.    Sheradsky T., "A new method for amination of anionic nitrogen" tetrahedron lett., vol. 9, No. 16,pp. 1909-1910 (1968).
19.    E.J.Gasson( Distillers Co. Ltd.) Brit.pal.,vol. 787,p.282(1957).
20.    Karpman Y. S. and Yakhontov L. N., "Esterification of isonicotinic acid with a action -exchange resin in the synthesis of isonicotinic hydrazide ", Pharm. Chem. J. vol. 14, No. 3 pp.199-202 (1980).
21.    K.K. Moll, Seefluth L. Briisehaber and G. Schrattenholz, Pharmazie Vol. 23, p. 36 (1968).
22.    Scott F.L. and Aylward J.B. "Hydrazidic halides, part IV (1) The solvollyses of p-substituted benzhydrazidic bromides "Tedrahedron let., vol. 6, No.13, pp. 841-847 (1965).
23.    Baranish I.T. And Gibson, M.S. "542. Hydrazones .part VI. The hydrazidic halide - acylhydrzide transformation", J. Chem. Soc., No.0, pp.2999-3001, (1965).
24.    Hegarty A.F., Aylward J.B. and Scott F.L., The rearrangement o new group of azides - hydrazidic azides", Tetrahedron Lett., Vol. 8, No. 14 ,pp. 1259 -1262 , (1967) .
25.    Sokolova T.A., Zapevalova N.P. (1969). Acylation of Hydrazine and Its Substituted Derivatives with Derivatives of αβ-unsaturated Monobasic Acids. Russian Chemical Reviews, 38 (12), 1001.
26.    Siddiqui N, Arshad MF, Khan SA. Synthesis of some new coumarins incorporated thiazolyl semicarbazones as anticonvulsants. Acta Pol Pharm. 2009 Mar-Apr; 66(2): 161-7. PMID: 19719050.
27.    Hamdoon A.M., Al-Iraqi M.A., Saleh M.Y. (2022). Synthesis of Some Multi-cyclic Sulfhydryl Donor Compounds Containing 1, 2-dithiol-3-thione moiety. Egyptian Journal of Chemistry, 65(3), 1-2.‏‏
28.    Ghoneim A.A. A clean procedure for synthesis of phenylquinoline derivatives. Orient J. Chem 2009; 25 (3).
29.    Samshuddin S., Narayana B., Sarojini B.K., Shetty D.N., Suchetha Kumara, "synthesis, characterization and Biological Evaluation of some New Functionalized Terphenyl Derivatives " Int.J.Med Chem. ,Vol .12 No.530392, pp1-13(2012).
30.    Kumar A., Jakhar A., Makrandi J.K. (2012). A highly efficient solvent free synthesis of hydrazides using grinding technique. Heterocyclic Letter, 2(4), 401-404.
31.    Joshi S.D., More Y., Vagdevi V.P., Vaidya G.S. Gadaginamath, and Kulkarni V.H., "Synthesis of new 4-(2,5-dimethylpyrrol -yl )4-pyrrol 1-yl benzoic acid hydrazide analogs and some derived oxadiazole, triazole and pyrrole ring systems: A novel class of potential antibacterial, anti-fungl and anti-tubercular agents. "Med. Chem. Res. Vol. 22, No. 3, pp.1073-1089 (2013)
32.    Srivastava S., Pandeya S.N., Yadav M.K., Singh B.K. Synthesis and analgesic activity of novel derivatives of 1, 2-substituted benzimidazoles. Journal of Chemistry, 2, No. 3, pp. 1073-1089, (2013).
33.    S.C. Basa and C. Srinivasulu (1981)" ONE-POT PROCESS FOR BENZOCAINE FROM p-NITROBENZOIC ACID", Organic Preparations and Procedures International, 13:6, 424-425, DOI: 10.1080/00304948109356156.
34.    Beenderly A., and Stavchansky S., "A new synthesis of carboxylic acid hydrazides via organ aluminum reagents ", Tetrahedron let. Vol. 29, No. 7, pp. 739 -740 (1988).
35.    Petrova T.D., Savchenko T.I., Shchegoleva L.N. et al. Polyfluorinated heterocyclic compounds. Chem. 6, 1251-1254 (1970).
36.    Aelony D. and Mckillip W.J. "Aminimide IX.A general synthesis of 1- substituted -2-imidazolidinones," J. Heterocyclic compounds., Vol. 9, No. 3, pp. 687-690 (1970).
37.    Fraenkel G. and Pecchold E., " Alocoxide cleavage of benzoyl -t- butyldiimide: carbanion and radical mechanisms, "Tetrahedron Lett. , Vol. 10 , No. 54, pp. 4821 -4824, (1969) .
38.    Sdeek G.T., Mauf R.M., Saleh M.Y. (2021). Synthesis and Identification of some new Derivatives Oxazole, Thiazole and Imidazol from Acetyl Cysteine. Egyptian Journal of Chemistry, 64(12), 7565-7571.‏
39.    Aanandhi M.V., Mansoori M.H., Shanmuga Gearge S., "Research Journal of pharmaceutical, Biological and Chemical oxadiazole derivattives", J. Pharm Biol Chem. Sci., Vol. 1, No. 4 pp.1083-1090.
40.    Mohamed F.K., "Synthesis, reaction and antimicrobial activity on some novel phthalazinones derivatives "Der Chem. Sin., Vol. 1, No. 1, pp. 20 -31 (2010).
41.    Pham V.H., Phan T., Phan D.C., Vu B.D. (2019). Synthesis and Bioactivity of Hydrazide-Hydrazones with the 1-Adamantyl-Carbonyl Moiety. Molecules (Basel, Switzerland), 24(21), 4000.
42.    Ayoob A.I., Sadeek G.T., Saleh M.Y. (2022). Synthesis and Biologically Activity of Novel 2-Chloro-3-Formyl-1, 5-Naphthyridine Chalcone Derivatives. Journal of Chemical Health Risks, 12(1), 73-79.‏
43.    Surajit J., Rajat S.,"Organizing hydrazides and their derivatives: synthesis, structural diversity and applications", New J. Chem., 2021,45, 10160-10169.
44.    Padmini K., Preethi P.J., Divya M., Rohini P., Lohita Swetha K., Kaladar "A Review on biological Impotance of Hydrazones" Int. J. Pharma Res. Rev., Vol. 2, No. 8, pp. 43-58, (2013).
45.    Meyer H. and Mally J. "über Hydrazinderivate der pyridincarbonsǟuren" Montashefte für Chemie und verwandte Teile anderer wissenschaften , Vol. 33, No. 4, pp. 393 - 414, (1912).
46.    El Sayed L.; Iskander M. Coordination compounds of hydrazine derivatives with transition metals-III: The reaction of aroyl hydrazones with Ni (II) and Cu (II) salts. J. Inorg. Nucl. Chem. 1971, 33, 435-443.
47.    D.Sriram P. Yogeeswari, K. Madhu, "Synthesis and in vitro and in vivo anti- mycobacterial activity of isonicotinoyl hydrazones " Bioorg. Med Chem. Lett., vol. 15, No. 20, pp. 4502 -4504, (2005).
48.    Demirbas N., Demirbas A., and Karaoglu S.A., "Synthesis and Biological Activities of New 1,2,4- Triazole -3- one Derivatives Russ j. Bioorganic Chem., Vol. 31, No. 4 pp. 387 - 397 (2005).
49.    Bernardino A.M.R., Gomes K.S., Charret A.C.C., Freitas G.M.C., Machado M.M., "Synthesis and Leisshmanichdal Activities of 1- (4-X-phenyl)-N- [(4-Y-Phenyl) methylene]-1H-pyrazole -4-carbohydrazides "Chem Inform., Vol.37, No. 27, (2006).
50.    Kucukguzel G.; Kocatepe A.; Clercq E.De; Sahin F.; Gulluce M.," Synthesis and biological activity of 4-thiazolidinones, thiosemicarbazides derived from diflunisal hydrazide. Eur. J. Med. Chem., 2006, 41, 353-359.
51.    Muscia G.C., Carnevale J.P., Bollini M., Asis S.E. (2008). Microwave‐assisted döbner synthesis of 2‐phenylquinoline‐4‐carboxylic acids and their antiphrastic activities. Journal of Heterocyclic Chemistry, 45(2), 611-614.
52.    Hunoora R.S.; Basavaraj R.P.; Dayananda S.B.; Vadavia R.S.; Gudasia K.B.; Chandrashekharb V.M.; Muchchandib I. S. "Spectroscopic, magnetic and thermal studies of Co(II), Ni(II), Cu(II) and Zn(II) complexes of 3-acetylcoumarin-isonicotinoylhydrazone and their antimicrobial and anti- tubercular activity evaluation". Spectrochimica Acta (A), 2010, 77, 838-844.
53.    Abdel-Aziz M., Abdel-Rahman H. M. "Synthesis and anti-mycobacterial evaluation of some pyrazine-2-carboxylic acid hydrazide derivatives". Eur. J. Med. Chem., 2010, 45, 3384-3388.
54.    S.Srivatava S.N., Pandeya M.K., Yadav B. K. Singh,"Synthesis and anal vity of novel derivatives of 1,2-substituted benzimidazole" J. Chem. vol. No. 4 , pp. 721-727, (2013)
55.    Palled M.S., Lohar V.R., Kalekar M.C., Patil P.B., Bhat A.R. Synthesis of 1,2,3,4-[ 1-N- Methyl Benzimidazole] 3-Phenyl Substituted Thiazolidine, 4-One and Carbohydrazide Derivatives for Antimicrobial Activity. Research J. Pharm. and Tech. 5(2): Feb. 2012; Page 249-252.
56.    Kirti Rani, Charanjit Kaur, Pardeep Kumar Sharma, Rajesh Kumar, Gurvinder Singh. Microwave assisted synthesis of N-substituted benzylidene-2-(1H-benzotriazol-1-yl) acetohydrazide derivatives as Antibacterial agents.
57.    A. Khodja R., Boulcina A. Debache and U.Constantine, "Research Article Copper (II)acetate promoted facile synthesis of dihydropyrimdinone derivatives via a solvent free Biginelli multicomponent reaction" J. Chem . Parma. Res. Vol. 6, No. 5, PP. 1040-1045, (2014).
58.    Saleem H.; Subashchandrabose S.; Babu N. R.; Padusha M.S.A. Vibrational spectroscopy investigation and density functional theory calculations on (E)-N0 - (4-methoxybenzylidene) benzohydrazide. Spectrochim. Acta. A Mol. Biomol. Spectrosc. 2015, 143, 230-241.
59.    Z.A. Abdallah, M. S. Mohamed Ahmed and M. M. Saleh, Organic synthesis and inhibition action of novel hydrazide derivative for mild steel corrosion in acid solutions, Mater. Chem. Phys., 2016, 174,91-99.
60.    Hamdoon A., Saleh M., Saied S. (2022). Synthesis & Biological Evaluation of Novel Series of Benzo[f]indazole Derivatives. Egyptian Journal of Chemistry, (), -. doi: 10.21608/ejchem.2022.120818.5418.
61.    R. Chabukswar P.V., Adsule P.B., Randhave Manini Mantri. Design, Synthesis and Antibacterial, Antifungal Activity of Some Coumarin Acetohydrazide Derivatives. Research Journal of Pharmacy and Technology. 2021; 14(7):3931-7.
62.    Kirti Rani, Charanjit Kaur, Pardeep Kumar Sharma, Rajesh Kumar, Gurvinder Singh. Microwave assisted synthesis of N-substituted benzylidene-2-(1H-benzotriazol-1-yl) acetohydrazide derivatives as Antibacterial agents
63.    El -Shehry M. F., Ghorab M. M., Abbas S. Y., Fayed E. A., Shedid S. A., Ammar Y. A. (2018). Quinolones derivatives bearing pyrazole moiety: synthesis and biological evaluation as possible antibacterial and antifungal agents. European journal of medicinal chemistry, 143, 1463-1473.
64.    Mohareb R.M., EL-Sharkawy K. A., Al Farouk F. O. (2019). Synthesis, cytotoxicity against cancer and normal cell lines of novel hydrazide-hydrazone derivatives bearing 5H-chromen-5-one. Medicinal Chemistry Research, 28(11), 1885-1900.
65.    Pradnya S. Sathe, Umesh D. Pete, Ratnamala S. Bendre. Synthesis, Characterization and Investigation of Anti-Oxidant Activity of Hydrazide-hydrazone Derivatives of 2-(2-Isopropyl-5-methyl phenoxy) Acetohydrazide. Asian J. Research Chem. 2018; 11(3):533-538.
66.    Ayoob A., Yahya O., Saleh, M. (2022). Synthesis and biological activity of 2-chloro-3-formyl-1,8-naphthyridine chalcone derivative. Egyptian Journal of Chemistry, (), -. doi: 10.21608/ejchem.2022.134661.5925
67.    Rajeshwari M. Eco friendly synthesis of N'-Arylidene-2-((7-bromo-2-methylpyrido[2,3-B]pyrazin-3-yl)oxy)acetohydrazides. Asian J. Research Chem. 2018; 11(2):279-281.
68.    Naveena Kumari H.M., Manjunath H.M., K.M. Basavaraja, "Synthesis, Characterization and Antimicrobial Activity of Benzofuran Derivatives "International Peer Reviewed Journal, 2021, 10 (4): 438-444.
69.    Mohamed M. Kaddah, Alaa R. I. Morsy, Abdelgawad A. Fahmi, Mustafa M. Kamel, Mounir M. Elsafty, Sameh A. Rizk and Sayed K. Ramadan (2021) Synthesis and biological activity on IBD virus of diverse heterocyclic systems derived from 2-cyano-N'-((2-oxo-1,2-dihydroquinolin-3-yl)methylene)acetohydrazide, Synthetic Communications, DOI: 10.1080/00397911.2021.1970776.
70.    Ram C. Senwar, Krishna K. Rathore, Anita Mehta. Synthesis and antimicrobial evaluation of Azetidinone derivatives of pyridine containing hydrazides. Asian J. Research Chem. 2017; 10(2):135-141.
71.    Saleh, A., Saleh, M. (2022). Synthesis of heterocyclic compounds by cyclization of Schiff bases prepared from capric acid hydrazide and study of biological activity. Egyptian Journal of Chemistry, (), -. doi: 10.21608/ejchem.2022.133946.5904
72.    Owaid, K. A., Hamdoon, A. A., Maty, R. R., Saleh, M. Y., Abdelzaher, M. A. (2022). Waste Polymer and Lubricating Oil Used as Asphalt Rheological Modifiers. Materials, 15(11), 3744.
73.    Vivekanand D. B., Mruthyunjayaswamy B. H. M. Synthesis characterization and antimicrobial activity studies of some transition metal complexes derived from 3-chloro-6-methoxy-N'-((2-thioxo-1, 2-dihydroquinolin-3-yl) methylene)benzo[b]thiophene-2-carboxyhydrazide. Asian J. Research Chem. 6(1): January 2013; Page 35-45
74.    Rekha K., Diwa M. and Arun S., Preparation and antimicrobial studies of novel fused heterocyclic compounds, R.J.C. Vol. 14, No. 3, 1947-1952, 2021.
75.    Manoj K.M., Ramana Reddy B., Balakrishna K., Rambabu G., Synthesis and Anticancer Activity of Novel Amide Tagged Trifluoromethyl Indole and Pyrimido Indole Derivatives,Asian Journal Chemistry , Vol.33, No.10, 2021, 2327-2332.
76.    Harer Sunil L, Rajurkar Vikas G, Kardile Nitin, Harer Priyanka S. Analgesic and Anti-inflammatory Activity of Some 2-Iodo-N'-[(1E)-Substituted Phenylmethylidene] Benzohydrazide Analogues. Asian J. Research Chem. 3(2): April- June 2010; Page 504-507.
77.    Al-Thakafy N., Al-Enizzi M., Saleh M. (2022). Synthesis of new Organic reagent by Vilsmeier – Haack reaction and estimation of pharmaceutical compounds (Mesalazine) containing aromatic amine groups. Egyptian Journal of Chemistry, 65(6), 685-697.  
78.    Saeed Z., Saleh M., Sadeek G. (2022). Synthesis and Biological Evolution of Novel Substituted 1,2,4-triazine from Sulfanilic Acid. Egyptian Journal of Chemistry, (), -.

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