Author(s):
Limce Thampi, Gini E J
Email(s):
limcesunil.02@gmail.com
DOI:
10.52711/0974-360X.2023.00250 
Address:
Limce Thampi*1, Gini E J2
1Department of Pharmaceutics, Chemists College of Pharmaceutical Sciences and Research, Varikoli P.O, Puthencruz, Ernakulam, Kerala, India - 682308.
2Department of Pharmacognosy, The Dale View College of Pharmacy and Research Centre, Punalal P.O, Thiruvananthapuram, Kerala, India - 695575.
*Corresponding Author
Published In:
Volume - 16,
Issue - 3,
Year - 2023
ABSTRACT:
Transungual drug delivery systems distribute therapeutic agents through the human nail, a unique way for delivering medications for nail disorders caused by fungal infections. The human nail is a hydrophilic barrier made up of keratinized cells that cover the nail bed and matrix underneath. For nail diseases, the systemic or oral mode of drug delivery reduces the drug's potency at the site of action. To achieve longer contact duration at the application site, it is necessary to increase drug absorption to the nail unit. The primary goal of this review paper is to provide an overview of characterization studies on physicochemical characteristics; in-vitro and in-vivo approaches for transungual drug delivery to treat nail fungal infections using medicated nail patches. However, in order to acquire a wide overview of the characterization elements of this rapidly increasing multidisciplinary field of study, a number of articles and technical studies dealing with nail patches were investigated. It also included the methodology employed in the characterization studies, as well as the implications for process design.
Cite this article:
Limce Thampi, Gini E J. In-vitro and In-vivo Characterization of Anti-Onychomycotic Transungual patches - A Systematic Review. Research Journal of Pharmacy and Technology 2023; 16(3):1527-2. doi: 10.52711/0974-360X.2023.00250
Cite(Electronic):
Limce Thampi, Gini E J. In-vitro and In-vivo Characterization of Anti-Onychomycotic Transungual patches - A Systematic Review. Research Journal of Pharmacy and Technology 2023; 16(3):1527-2. doi: 10.52711/0974-360X.2023.00250 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2023-16-3-86
REFERENCES:
1. Firoz S, Sirisha MN, Rajalakshmi R. Transungual drug delivery system: a review. Int. J. Innov. Drug. Disc. 2011; 1:9-14.
2. Sousa F, Ferreira D, Reis S, Costa P. Current insights on antifungal therapy: Novel nanotechnology approaches for drug delivery systems and new drugs from natural sources. Pharmaceuticals. 2020 Sep; 13(9):248. doi.org/10.3390/ph13090248
3. Rai S, Kamath BV, Subrahmanyam VM. Strategies for treatment of Onychomycosis. Research Journal of Pharmacy and Technology. 2018;11(11):5135-8. doi: 10.5958/0974-360X.2018.00937.X
4. Dhamoon RK, Popli H, Gupta M. Novel drug delivery strategies for the treatment of onychomycosis. Pharm. Nanotechnol. 2019 Feb; 7(1):24-38. doi: 10.2174/2211738507666190228104031
5. Srinidhi KR, Subrahmanyam VM, Alex AT, Mathew AJ, Kamath BV. Role of Nano-formulation in the treatment of Onychomycosis. Research Journal of Pharmacy and Technology. 2020;13(1):453-5. doi: 10.5958/0974-360X.2020.00088.8
6. Rizi K, Mohammed IK, Xu K, Kinloch AJ, Charalambides MN, Murdan S. A systematic approach to the formulation of anti-onychomycotic nail patches. Eur. J. Pharm. Biopharm. 2018 Jun; 127(1):355-65. doi: 10.1016/j.ejpb.2018.02.032
7. Pardeshi HA, Gambhire MS, Gujar KN, Vaidhya AA. Development and Evaluation of Ketoconazole Loaded Nano-sponges for Topical Drug Delivery. Int. J. Pharm. Sci. Nanotech. 2018 Jul; 11(4):4154-62. doi.org/10.37285/ijpsn.2018.11.4.2
8. Atay O, Selçk F. Quantitative determination of fluconazole by infrared spectrophotometry. Anal. Lett. 1996 Sep; 29(12):2163-76. doi.org/10.1080/00032719608002239
9. Muralichand G, Bhikshapathi DV. Preparation and in vitro Evaluation of Solid Dispersions Containing Nifedipine. Int. J. Pharm. Sci. Drug Res. 2018; 10(4):260-7. doi.org/10.25004/IJPSDR.2018.100408
10. Samyuktha Metta DK. Development and Evaluation of a Novel Transungual Formulation (Nail Patch) for the Treatment of Onychomycosis. Int.J. Innov. Sci. Res.Tech. 2018; 3(6):562-579. doi.org/10.1016/j.jdermsci.2006.12.010
11. Boddeda B, Suhasini MS, Niranja P, Ramadevi M, Anusha N. Design, evaluation and optimization of fluconazole transdermal patch by 2 2 factorial method. Der Pharmacia Lettre. 2016;8(5):280-7.
12. Minghetti P, Cilurzo F, Montanari L. Evaluation of adhesive properties of patches based on acrylic matrices. Drug development and industrial pharmacy. 1999 Jan 1;25(1):1-6.doi: 10.1081/ddc-100102135.
13. Minghetti P, Casiraghi A, Cilurzo F, Montanari L. Evaluation of adhesive properties of transdermal therapeutic systems containing nitroglycerin. Bull. Chim. Farm. 2001 Mar-Apr; 140(2):63-7. PMID: 11417388
14. Lakhani P, Bahl R, Bafna P. Transdermal Patches: Physiochemical and in-vitro Evaluation Methods. Int. J. Pharm. Sci. Res. 2015 May; 6(5):1826. doi:10.13040/IJPSR.0975-8232.6(5). 1826-36
15. Palliyil B, Lebo DB. A novel transungual formulation (nail patch) for delivery of Ciclopirox olamine into the nail and the nail folds. Int. J. Pharm. Med. Biol. Sci. 2014; 3(3):13.
16. Fernández-Campos F, Navarro F, Corrales A, Picas J, Pena E, González J, Otero-Espinar FJ. Transungual Delivery, Anti-Inflammatory Activity, and In Vivo Assessment of a Cyclodextrin Polypseudorotaxanes Nail Lacquer. Pharmaceutics. 2020 Aug;12 (8):730.doi: 10.3390/pharmaceutics12080730
17. Nair AB, Al-Dhubiab BE, Shah J, Gorain B, Jacob S, Attimarad M, Sreeharsha N, Venugopala KN, Morsy MA. Constant Voltage Iontophoresis Technique to Deliver Terbinafine via Transungual Delivery System: Formulation Optimization Using Box–Behnken Design and In Vitro Evaluation. Pharmaceutics. 2021 Oct; 13(10):1692.doi.org/10.3390/ pharmaceutics13101692
18. Aggarwal R, Targhotra M, Sahoo PK, Chauhan MK. Efinaconazole nail lacquer for the transungual drug delivery: Formulation, optimization, characterization and in vitro evaluation. J. Drug Deliv. Sci. Technol. 2020 Dec 1; 60: 101998. Doi:10.1016/j.jddst.2020.101998
19. Sakhare AD, Biyani KR, Sudke SG. Design and evaluation of adhesive type transdermal patches of Carvedilol. Res. J. Pharm. Technol. 2020; 13(10):4941-4949.doi: 10.5958/0974-360X.2020.00867.7
20. Ho HN, Le TG, Dao TT, Le TH, Dinh TT, Nguyen DH, Tran TC, Nguyen CN. Development of Itraconazole-Loaded Polymeric Nanoparticle Dermal Gel for Enhanced Antifungal Efficacy. J. Nanomater. 2020 Dec 31; 2020.doi: 10.1155/2020/8894541
21. Westerberg DP, Voyack MJ. Onychomycosis: current trends in diagnosis and treatment. Am. Fam. Physician. 2013 Dec; 88(11):762-70. PMID: 24364524
22. Lee BC, Pangeni R, Na J, Koo KT, Park JW. Preparation and in vivo evaluation of a highly skin-and nail-permeable Efinaconazole topical formulation for enhanced treatment of onychomycosis. Drug Deliv. 2019 Jan; 26(1):1167-77. doi: 10.1080/10717544.2019.1687612
23. Ofokansi KC, Kenechukwu FC, Ogwu NN. Design of novel miconazole nitrate transdermal films based on Eudragit RS100 and HPMC hybrids: preparation, physical characterization, in vitro and ex vivo studies. Drug Deliv. 2015 Nov; 22(8):1078-85.doi: 10.3109/10717544.2013.875604
24. Tupaki-Sreepurna A, Jishnu BT, Thanneru V, Sharma S, Gopi A, Sundaram M, Jyoti Kindo A. An assessment of in vitro antifungal activities of efinaconazole and itraconazole against common non-dermatophyte fungi causing onychomycosis. J. Fungi. 2017 Jun: 3(2):20.doi: 0.3390/jof3020020
25. Silva-Neves V, Hugo V, Alves P, Amado JC, Pais-Vieira C, Sousa F, Cerqueira F, Pinto E, Pais-Vieira M. Quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions. Sci. Rep. 2021 Jun 17;11(1): 12789. doi:10.1038/s41598-021-92111-4
26. Thatai P, Kaur K, Sapra B. In-vitro evaluation of Transungual formulation of ketoconazole for the Management of Onychomycosis. Drug Deliv. Lett. 2018 Aug 1;8(2):140-52. doi:10.2174/2210303108666180313141228
27. Anti-Dermatophytes Activity of some Algal Extracts Isolated From Baghdad City-Iraq Maarb S. Al-maoula Ahmed S. Dwaish.doi: 10.5958/0974-360X.2018.00993.9
28. Krishnan Y, Mukundan S, Akhil S, Gupta S, Viswanad V. Enhanced lymphatic uptake of Leflunomide loaded Nanolipid carrier via chylomicron formation for the treatment of rheumatoid arthritis. Adv. Pharm. Bull. 2018 Jun; 8(2):257.doi: 10.15171/apb.2018.030
29. Shimamura T, Kubota N, Nagasaka S, Suzuki T, Mukai H, Shibuya K. Establishment of a novel model of onychomycosis in rabbits for evaluation of antifungal agents. Antimicrob. Agents Chemother. 2011 Jul; 55(7):3150-5.doi: 10.1128/AAC.00399-11
30. Shimamura T, Kubota N, Shibuya K. Animal model of dermatophytosis. J. Biomed. Biotechnol. 2012 April; DOI:10.1155/2012/125384.doi: 10.1155/2012/125384
31. Shanbhag PP, Jani U. Drug delivery through nails: Present and future. New Horiz. Transl. Med. 2017 Jan 1;3(5):252-63.doi: 10.1016/j.nhtm.2017.01.002