Author(s):
Kamya Goyal, Anju Goyal, Rajendra Awasthi, Nidhi Rani, Rajwinder Kaur
Email(s):
rajwinder.kaur@chitkara.edu.in
DOI:
10.52711/0974-360X.2023.00317 
Address:
Kamya Goyal1,2, Anju Goyal2, Rajendra Awasthi3, Nidhi Rani2, Rajwinder Kaur2*
1Department of Pharmaceutical Chemistry and Analysis, Laureate Institute of Pharmacy, Jawalamukhi, Himachal Pradesh, India.
2Department of Pharmaceutical Chemistry, Chitkara College of Pharmacy, Chitkara University, Punjab, India.
3Department of Pharmaceutical Sciences, School of Health Sciences and Technology, University of Petroleum and Energy Studies (UPES), Energy Acres, Dehradun, Uttarakhand, India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 4,
Year - 2023
ABSTRACT:
In recent years, complications of micro-organisms, which becomes drug-resistant, have extended dreadful level across the globe. One of the significant challenges in drug discovery to overcome the increased development of drug resistance is developing novel chemical moieties that advantageously comprise chemical features different from existing chemical entities. This communication presents the synthesis, docking, and antibacterial and antifungal evaluation of nitro chalcones. New series of nitro substituted chalcone derivatives (1-12) were synthesized via Claisen-Schmidt condensation using substituted acetophenone and various substituted benzaldehydes in the presence of base and ethanol. Spectral analysis of the synthesized compounds was carried out using 1H-NMR, IR, 13C-NMR and HRMS methods. Synthesized derivatives were evaluated for antimicrobial potency via the microdilution method against two Gram-positive and two Gram-negative bacterial strains and two fungal strains. All compounds showed promising antimicrobial potency. However, compound 6 was the most potent derivative of the series against all the tested antibacterial strains. Compounds 10 and 12 were found to be the most potent analogues of the series against all the tested antifungal strains. All the synthesized derivatives had good antifungal potency in comparison to the antibacterial potency. Based on the preliminary study results, the study concluded that the synthesized chalcones derivatives promise antimicrobial activity that may be further investigated to achieve antimicrobial lead.
Cite this article:
Kamya Goyal, Anju Goyal, Rajendra Awasthi, Nidhi Rani, Rajwinder Kaur. Synthesis and Biological Evaluation of Nitro-substituted chalcones as potent Antibacterial and Antifungal agents. Research Journal of Pharmacy and Technology 2023; 16(4):1931-9. doi: 10.52711/0974-360X.2023.00317
Cite(Electronic):
Kamya Goyal, Anju Goyal, Rajendra Awasthi, Nidhi Rani, Rajwinder Kaur. Synthesis and Biological Evaluation of Nitro-substituted chalcones as potent Antibacterial and Antifungal agents. Research Journal of Pharmacy and Technology 2023; 16(4):1931-9. doi: 10.52711/0974-360X.2023.00317 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2023-16-4-66
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