Author(s): Sanjay Kumar Gupta, Sradhanjali Patra

Email(s): snj.gupta4@gmail.com

DOI: 10.52711/0974-360X.2023.00396   

Address: Sanjay Kumar Gupta1*, Sradhanjali Patra2
1Research Scholar, University Department of Pharmaceutical Sciences, Utkal University, Bhubaneswar, Odisha.
2University Department of Pharmaceutical Sciences, Utkal University, Bhubaneswar, Odisha.
*Corresponding Author

Published In:   Volume - 16,      Issue - 5,     Year - 2023


ABSTRACT:
The aim of this investigation was to develop and optimize the Sustained release Matrix formulations of Repaglinide (RLD) using response surface methodology by employing a 3-factor, 3-level Box–Behnken statistical design. The independent variables studied were the amount of hydroxypropyl methylcellulose (HPMC K4M), Ethyl cellulose (EC) and PVP K30. The Swelling index (Y1), drug release at 8 hr and 12hr were the target responses. The response surface methodology and multiple response optimizations utilizing a polynomial equation were used to search for the optimal formulation with a specific release rate at different time intervals. The results showed that the effect of combination of HPMC K4M and EC was the most influencing factor on the drug release from ER matrix tablets. The mechanism of drug release from RLD Matrix tablets was dependent on the added amount of EC. Validation of the optimization technique demonstrated the reliability of the model. The optimized formulation containing 50mg of HPMC K4, 35mg of EC, and 30mg of PVP K30 was prepared according to the software determined levels. DSC and FTIR studies combined with the stability study of the optimized formulation proved the integrity of the developed formulation. The Box–Behnken experimental design facilitated the formulation and optimization of extended release hydrophilic matrix systems of RLD in a short period of time and with the fewest number of experiments. The optimized Matrix tablet of Repaglinide showed good pharmacokinetic result over conventional formulation.


Cite this article:
Sanjay Kumar Gupta, Sradhanjali Patra. Preparation, Characterization and Optimization of Sustained Release Matrix Tablets of Repaglinide using Box–Behnken Design. Research Journal of Pharmacy and Technology 2023; 16(5):2403-0. doi: 10.52711/0974-360X.2023.00396

Cite(Electronic):
Sanjay Kumar Gupta, Sradhanjali Patra. Preparation, Characterization and Optimization of Sustained Release Matrix Tablets of Repaglinide using Box–Behnken Design. Research Journal of Pharmacy and Technology 2023; 16(5):2403-0. doi: 10.52711/0974-360X.2023.00396   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2023-16-5-55


REFERENCES:
1.    Peterson, G., Current treatments and strategies for type 2 diabetes: can we do better with GLP-1 receptor agonists? Annals of Medicine. 2012. 44(4): p. 338-349. https://doi.org/10.3109/07853890.2011.653392
2.    Kostov, K., Effects of magnesium deficiency on mechanisms of insulin resistance in type 2 diabetes: focusing on the processes of insulin secretion and signaling. International Journal of Molecular Sciences, 2019. 20(6): p. 1351. https://doi.org/10.3390/ijms20061351
3.    Ryan, D., et al., The global pandemic of overweight and obesity: Addressing a twenty-First century multifactorial disease. Handbook of Global Health. 2020: p. 1-35. https://doi.org/10.1007/978-3-030-45009-0_39
4.    Ahmad, I., et al., Optimization by design of etoposide loaded solid lipid nanoparticles for ocular delivery: Characterization, pharmacokinetic and deposition study. Materials Science and Engineering: C. 2019. 100: p. 959-970. https://doi.org/10.1016/j.msec.2019.03.060
5.    Guo, X., Physicochemical and mechanical properties influencing the drug release from coated dosage forms. 1996: The University of Texas at Austin.
6.    Ramteke, K., et al., Mathematical models of drug dissolution: a review. Sch. Acad. J. Pharm., 2014; 3(5): 388-396.
7.    Costa, P. and J.M.S.J.E.J.O.P.S. Lobo, Modeling and comparison of dissolution profiles. European Federation for Pharmaceutical Sciences (EUFEPS). 2001. 13(2): p. 123-133. https://doi.org/10.1016/S0928-0987(01)00095-1
8.    Fu, Y. and W.J.J.E.o.o.d.d. Kao. Drug release kinetics and transport mechanisms of non-degradable and degradable Polymeric Delivery Systems. Expert Opin Drug Deliv. 2010. 7(4): p. 429-444. https://doi.org/10.1517/17425241003602259
9.    Nagarwal, R.C., D.N. Ridhurkar, and J.J.A.P. Pandit, In vitro release kinetics and bioavailability of gastroretentive cinnarizine hydrochloride tablet. AAPS PharmSciTech. 2010. 11(1): p. 294-303. https://doi.org/10.1208/s12249-010-9380-5
10.    Sriamornsak, P., et al., Swelling and erosion of pectin matrix tablets and their impact on drug release behavior. Eur J Pharm Biopharm. 2007. 67(1): p. 211-219. https://doi.org/10.1016/j.ejpb.2006.12.014
11.    Schoepf, J., Tiered Approach to Detect Nanomaterials in Food and Environmental Matrices. 2018, Arizona State University.
12.    Mukhopadhyay, D., J.P. Sarkar, and S.J.J.o.B.T. Dutta, Optimization of process parameters for the economical generation of biogas from raw vegetable wastes under the positive influence of plastic materials using response surface methodology. J Biochem Tech. 2013. 4(1): p. 549-553.
13.    Velpandian, T., et al., Development and validation of a new high-performance liquid chromatographic estimation method of meloxicam in biological samples. Chromatogr B Biomed Sci Appl. 2000. 738(2): p. 431-436. https://doi.org/10.1016/S0378-4347(99)00537-X
14.    Mujtaba, A., et al., Statistical optimization and characterization of pH-independent extended-release drug delivery of cefpodoxime proxetil using Box–Behnken design. 2014. 92(1): p. 156-165. https://doi.org/10.1016/j.cherd.2013.05.032
15.    Deepa R. Patel, Laxmanbhai J. Patel, Madhabhai M. Patel. Stability Indicating HPLC Method for Simultaneous Determination of Repaglinide and Metformin Hydrochloride in Pharmaceutical Dosage Form. Asian J. Research Chem. 4(3): March 2011; Page 500-505.
16.    Hyma Ponnaganti, Abbulu. K. Enhanced Dissolution of Repaglinide: SMEDDS Formulation and In-vitro Evaluation. Research J. Pharm. and Tech. 7(11): Nov. 2014 Page 1246-1252.
17.    Ajeet Singh, Ranjit Singh. Development and Characterization of Repaglinide Loaded Floating Microparticles. Research Journal of Pharmacy and Technology. 2021; 14(12):6573-8. Doi:10.52711/0974-360X.2021.01137
18.    S. Sivaprasad, V. Alagarsamy, M. Prathibha Bharathi, P.V. Murali Krishna, K. Sandeeep Kanna. Formulation and Evaluation of Mucoadhesive Floating Microspheres of Repaglinide. Research Journal of Pharmacy and Technology. 2021; 14(11):5673-9. http://dx.doi.org/10.52711/0974-360X.2021.00986
19.    C.C. Patil, J. Vekatesh, Karajgi S. R, Vijapure Vitthal, Ashwini G., Jorapur P. N., Chetan M. Formulation and in vitro Evaluation of Matrix tablets containing Repaglinide. Research Journal of Pharmacy and Technology. 2021; 14(8):4429-4. DOI:10.52711/0974-360X.2021.00769
20.    Afroz Patan, Syed Reeyaz Basha, Ravi Kumar Ketha, et al, Development and Validation of New RP- HPLC Method for the Simultaneous Estimation of Metformin Hydrochloride and Repaglinide in Pure and Pharmaceutical Formulations. Research J. Pharm. and Tech. 2021; 14(3):1323-1328.
21.    Mohanty, D., Rani, M.J., Haque, M.A., Bakshi, V., Jahangir, M.A., Imam, S.S. and Gilani, S.J., 2020. Preparation and evaluation of transdermal naproxen niosomes: formulation optimization to preclinical anti-inflammatory assessment on murine model. Journal of Liposome Research. 30(4), pp.377-387. https://doi.org/10.1080/08982104.2019.1652646
22.    B. Ramu, Kaushal K. Chandrul, P. Shanmuga Pandiyan. Using 24 Factorial Designs optimization of Repaglinide Gastroretentive Drug Delivery System. Research J. Pharm. and Tech. 2021; 14(2):725-729.

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