Author(s):
Saumya Das, Nashra, Manas Kumar Das, Rameshwar Gaur, Daivik Mittal, Mohammad Mubashshir Shahid
Email(s):
awasthi.saumya22@gmail.com , nashrashafiq007@gmail.com , manas.kd@gmail.com
DOI:
10.52711/0974-360X.2023.00404
Address:
Saumya Das*, Nashra, Manas Kumar Das, Rameshwar Gaur, Daivik Mittal, Mohammad Mubashshir Shahid
1Noida Institute of Engineering and Technology (Pharmacy Institute), Department of Pharmacology, Plot No - 19, Knowledge Park - II, Greater Noida, Uttar Pradesh, 201306, India.
2Orlean College of Pharmacy, Department of Pharmacology, Knowledge Park-III, Greater Noida, Uttar Pradesh, 201308, India.
3Lloyd Institute of Management and Technology (Pharmacy Institute), Department of Pharmacology, Plot No-11, Knowledge Park-II, Greater Noida, Uttar Pradesh, 201306, India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 5,
Year - 2023
ABSTRACT:
Background: The primary cause of intestinal and colon inflammation is inflammatory bowel disease (IBD).Preclinical ulcerative colitis is poorly definedin this article we providea scientific validation in preclinical systemic inflammation in ulcerative colitis by the means of phytochemical lupeol as a source of triterpenoid rich food. Aim: The aim of the present study was to evaluate the bioactive phytochemical, lupeol for the management of IBD through two different experimental models. Method: The intestinal anti-inflammatory models for rat colitis were performed by using TNBS and DSS to access the use of lupeol (25µg/ml and 50µg/ml) in ulcerative colitis. Change in body weight, stool consistency, colon weight/length and histological examination of colon were performed. Results: Lupeol showed significant anti-inflammatory impact in the colon at both the doses in TNBS and DSS models. The results of lupeol showed marked evidence both by histologically and also by the tissue recovery seen in various parameters like, Change in body weight, stool consistency and colon weight/length. Conclusion: The findings of this study provide the full proof rationale for additional research using lupeol in the successful management of ulcerative colitis.
Cite this article:
Saumya Das, Nashra, Manas Kumar Das, Rameshwar Gaur, Daivik Mittal, Mohammad Mubashshir Shahid. Preventive role of Dietary Phytochemical Lupeol in Preclinical Ulcerative Colitis Models. Research Journal of Pharmacy and Technology 2023; 16(5):2451-7. doi: 10.52711/0974-360X.2023.00404
Cite(Electronic):
Saumya Das, Nashra, Manas Kumar Das, Rameshwar Gaur, Daivik Mittal, Mohammad Mubashshir Shahid. Preventive role of Dietary Phytochemical Lupeol in Preclinical Ulcerative Colitis Models. Research Journal of Pharmacy and Technology 2023; 16(5):2451-7. doi: 10.52711/0974-360X.2023.00404 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2023-16-5-63
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