Author(s):
Nirav P. Chauhan, Naazneen Surti, Manish P. Patel
Email(s):
niravpharma07@gmail.com
DOI:
10.52711/0974-360X.2023.00539 
Address:
Nirav P. Chauhan*, Naazneen Surti, Manish P. Patel
Gujarat Technological University, Ahmedabad, Gujarat, India.
L. M. College of Pharmacy, Ahmedabad, Gujarat, India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 7,
Year - 2023
ABSTRACT:
Aim: The aim is to develop simple validated analytical method for analysis of Methoxy-Poly (Ethylene Glycol)-Succinimidyl Succinate (5000) by UV Spectroscopy and to study the forced degradation. Results and conclusion: The proposed method was successfully applied for the determination of Methoxy-Poly (Ethylene Glycol)-Succinimidyl Succinate in bulk. The results were demonstrated, that the procedure is accurate, precise and reproducible (relative standard deviation < 2%).
Cite this article:
Nirav P. Chauhan, Naazneen Surti, Manish P. Patel. Analytical Method Development and Validation of Methoxy-Poly (Ethylene Glycol)-Succinimidyl Succinate (5000) Linker by UV Spectroscopy. Research Journal of Pharmacy and Technology 2023; 16(7):3275-9. doi: 10.52711/0974-360X.2023.00539
Cite(Electronic):
Nirav P. Chauhan, Naazneen Surti, Manish P. Patel. Analytical Method Development and Validation of Methoxy-Poly (Ethylene Glycol)-Succinimidyl Succinate (5000) Linker by UV Spectroscopy. Research Journal of Pharmacy and Technology 2023; 16(7):3275-9. doi: 10.52711/0974-360X.2023.00539 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2023-16-7-36
REFERENCES:
1. Menon Rudolph S, Zalipsky S, Seltzer R. Covalent attachment of polyethylene glycol to proteins and evaluation. Biotechnology and Applied Biochemistry. 1992;15(1):100–14.doi.org/10.1111/j.1470-8744.1992.tb00198.x
2. Bentley MD, Roberts MJ, Harris JM. Protein PEGylation and its chemistry. Advanced Drug Delivery Reviews. 2002 Jun 17;54(4):459–76.doi.org/10.1016/S0169-409X(02)00022-4
3. Hsu H-J, Han Y, Cheong M, Král P, Hong S. Dendritic PEG outer shells enhance serum stability of polymeric micelles. Nanomedicine. 2018 Aug;14(6):1879–89.DOI: 10.1016/j.nano.2018.05.010
4. Calvo P, Gouritin B, Angelo JD, Noel J, Georgin D, Fattal E, et al. Long-circulating PEGylated polycyanoacrylate nanoparticles as new drug carrier for brain delivery. Pharm Res. 2001; 18(8):1157–66. Doi: 10.1023/a: 1010931127745.
5. Sánchez-López E, Ettcheto M, Egea MA, Espina M, Calpena AC, Folch J, et al. New potential strategies for Alzheimer’s disease prevention: pegylated biodegradable dexibuprofen nanospheres administration to APPswe/PS1dE9. Nanomed Nanotechnol Biol Med. 2016;13:1171–82.doi.org/10.1016/j.nano.2016.12.003
6. Jain A, Chasoo G, Singh SK, Saxena AK, Jain SK. Transferrin-appended PEGylated nanoparticles for temozolomide delivery to brain: in vitro characterisation. Journal of Microencapsulation. 2011 Feb 1;28(1):21–8.doi.org/10.3109/02652048.2010.522257
7. Zhang X, Chen G, Zhang T, Ma Z, Wu B. Effects of PEGylated lipid nanoparticles on the oral absorption of one BCS II drug: a mechanistic investigation. IJN. 2014 Nov 26;9(1):5503–14.
8. Zhao S, Wang W, Huang Y, Fu Y, Cheng Y. Paclitaxel loaded human serum albumin nanoparticles stabilized with intermolecular disulfide bonds. Med Chem Commun. 2014 Oct 23;5(11):1658–63.
9. Pang X, Yang P, Wang L, Cao J, Cheng Y, Sheng D Human serum albumin nanoparticulate system with encapsulation of gefitinib for enhanced anti-tumor effects in non-small cell lung cancer. Journal of Drug Delivery Science and Technology. 2019 Aug 1;52:997–1007.
10. Wan X, Zheng X, Pang X, Zhang Z, Jing T, Xu W The potential use of lapatinib-loaded human serum albumin nanoparticles in the treatment of triple-negative breast cancer. International Journal of Pharmaceutics. 2015 Apr 30;484(1):16–28.
11. Cho H-Y, Lee CK, Lee Y-B. Preparation and Evaluation of PEGylated and Folate-PEGylated Liposomes Containing Paclitaxel for Lymphatic Delivery. Journal of Nanomaterials. 2015 Jan 20;2015:e471283. doi.org/10.1155/2015/471283
12. Wei M, Guo X, Tu L, Zou Q, Li Q, Tang C, et al. Lactoferrin-modified PEGylated liposomes loaded with doxorubicin for targeting delivery to hepatocellular carcinoma. IJN. 2015 Aug 12;10(1):5123–37.doi.org/10.2147/IJN.S87011
13. Ghaferi M, Asadollahzadeh MJ, Akbarzadeh A, Ebrahimi Shahmabadi H, Alavi SE. Enhanced Efficacy of PEGylated Liposomal Cisplatin: In Vitro and In Vivo Evaluation. International Journal of Molecular Sciences. 2020 Jan;21(2):559. doi.org/10.3390/ijms21020559
14. Yani MV, Anjani IAW, Narayana IGS, Wihandani DM, Supadmanaba IGP. Combination of Cisplatin-Withaferin Based on PEGylated Liposome Nanoparticles as Alternative Therapy for Ovarian Cancer. Journal of Medicine and Health.2020,2(5):1129
15. Taneja N, Singh KK. Rational design of polysorbate 80 stabilized human serum albumin nanoparticles tailored for high drug loading and entrapment of irinotecan. International Journal of Pharmaceutics. 2018 Jan 30;536(1):82–94.DOI: 10.1016/j.ijpharm.2017.11.024
16. Almandoz MC, Sancho MI, Duchowicz PR, Blanco SE. UV–Vis spectroscopic study and DFT calculation on the solvent effect of trimethoprim in neat solvents and aqueous mixtures. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2014 Aug 14;129:52–60. doi.org/10.1016/j.saa.2014.02.191
17. Yu M, Ding Z, Jiang F, Ding X, Sun J, Chen S, et al. Analysis of binding interaction between pegylated puerarin and bovine serum albumin by spectroscopic methods and dynamic light scattering. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2011 Dec 1;83(1):453–60.
18. S S, K R, T AS. Analytical Method Development and Validation of Caffeine in Tablet Dosage Form By Using UV- Spectroscopy. 1. 2013 Jul 10;3(4):82–6.
19. Sri KV, Jain GV, Maduri M. UV Spectrophotometric Method for the Estimation of Rilpivirine in Bulk and Pharmaceutical Formulations. Research Journal of Pharmacy and Technology. 2014 Apr 28;7(4):463–6. doi.org/10.5958/0974-360X
20. Andressa TS, Gabriela R B, Isadora DM, Lisiane B, Donadel MM, Clésio SP. UV spectrophotometric method for quantitative determination of Bilastine using experimental design for robustness. Drug Analytical Research. 2017; 01(2): 38-43.doi.org/10.22456/2527-2616.79221
21. M Sashikala, S Mohan et .al; Validated UV-Visible Spectroscopic Analytical method development and stability studies on Oseltamivir. Research Journal of Pharmacy and Technology. 2020 Sep 4;13(9):4323–8. doi.org/10.5958/0974-360X.2020.00764.7
22. Lavanya Latha Reddy K., Sowjanya T., Bandhavi P., Raveendranath T., R.B. Desireddy, Naga Sowjanya G. Development and Validation of UV Spectrophotometric Method for Estimation of Amlodipine Besylate in Tablet Dosage Form. Research Journal of Pharmacy and Technology. 2012 Oct 28;5(10):1320–3.
23. Manfed E. Wolff. Burger’s Medicinal Chemistry and Drug Discovery: Therapeutic Agent. John Willy and Sons, INC, New York.1997; Vol 5, 5th Ed.
24. Mastanamma SK, Reehana SK, L P, Kiran R. UV Spectrophotometric Method for the Determination of Sirolimus in Bulk and its Dosage Form. Research Journal of Pharmacy and Technology. 2019 Apr 30;12(4):1655–8. doi.org/10.5958/0974-360X.2019.00277.4
25. Sumithra M, Yuvanesh P, Mistry A. Analytical method development and validation of ambroxol hydrochloride by UV spectroscopy and forced degradation study and detection of stability. Research Journal of Pharmacy and Technology. 2016 Jul 28;9(7):794–800.doi.org/10.5958/0974-360X.2016.00152.9
26. Tegeli V, Birajdar A, Matole V. UV Spectrophotometric Method Development and Validation of Darunavir in bulk and Solid Dosage Form. Research Journal of Pharmacy and Technology. 2021 Jun 29;14(6):3262–4.doi.org/10.52711/0974-360X.2021.00567
27. Prof. Sushil D. Patil, Tejashri Dugaje, Dr. Sanjay J. Kshirsagar. Development and Validation of UV Spectrophotometric Method for Estimation of Cyproheptadine hydrochloride. Asian Journal of Research in Chemistry. 2019; 12(2):112-115.
28. Attia K. A. M. et al. spectrophotometric determination of Acotiamide hydrochloride tri-hydrate in the presence of its degradative product. The Journal of Biological and Chemical Luminescence. 2018; 1: 1-6
29. Vijayraj S. et al. Analytical process of drug by ultraviolet (UV) spectroscopy: A review. International Journal of Pharmaceutical Research and Analysis. 2012; 2 (2): 72-78.