ABSTRACT:
Large numbers of drugs are available in the market in form of dry syrup, where reconstitution has to be done by patient. Ornidazole is an antibiotic used to treat some protozoan infections. It has also been investigated for use in Crohn's disease after bowel resection. In the present investigation the drug Ornidazole was selected for the design of oral reconstitutable suspension for improving its stability and palatability by using various techniques like physical mixing, solvent evaporation and co-grinding method with different suspending agents like Xanthan gum, SCMC, Guar gum and sodium alginate. The reconstitutable suspensions were evaluated for flow properties, particle size, pH, viscosity, sedimentation volume, redispersibility and drug release by in-vitro dissolution studies. Formulated OFS reconstitutable suspension has acceptable sedimentation properties. The drug excipients interactions and crystal morphology of optimized reconstitutable suspension were evaluated by Fourier transform infrared spectroscopy (FTIR), differential scanning Calorimetry (DSC), analysis. The results indicated that the release of the Ornidazole was rapid from all formulations than the pure drug. The drug release from the suspensions followed first order kinetics. From the results it is concluded that effective taste masking of Ornidazole was achieved using SCMC and successfully evaluated in reconstitutable suspension.