Author(s):
S. Baataoui, M. Chakit, M. Boudhan, M. Ouhssine
Email(s):
s.baataoui@gmail.com
DOI:
10.52711/0974-360X.2023.00563 
Address:
S. Baataoui1*, M. Chakit2, M. Boudhan3, M. Ouhssine1
1Natural Resources and Sustainable Development Laboratory,
Faculty of Sciences, Ibn To fail University. Kenitra, Morocco.
2Biology and Health Laboratory, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco.
3Medical Biology Analysis Laboratory Mimosas, Kenitra, Morocco.
*Corresponding Author
Published In:
Volume - 16,
Issue - 7,
Year - 2023
ABSTRACT:
Obesity and vitamin D deficiency have both been identified as major public health problems around the world. Overweight and obesity can cause many complications, including cardiovascular complications, but can also disrupt phosphocalcic metabolism, the objectives of our work are first of all: To write the phosphocalcic profile, the lipid balance as well as the dosage of vitamin D in an obese and overweight population, and to understand if the insufficiency in vitamin D is a cause or consequence of obesity. This is a descriptive cross-sectional study. It took place at the Mimosas Kenitra, Medical Analysis Laboratory for 18 months. The population concerned includes subjects Men and women aged between 20 years and 70 years who have BMI (Weight/height2)>25. Patients who are morbidly obese present a vitamin D deficiency of 60%, while 30% of obese patients with vitamin D deficiency were normal. The work of this thesis evaluated the phosphocalcic balance as well as the concentration of vitamin D.
Cite this article:
S. Baataoui, M. Chakit, M. Boudhan, M. Ouhssine. Assessment of Vitamin D, Calcium, Cholesterol, and Phosphorus status in Obese and Overweight patients in Kenitra city (Morocco). Research Journal of Pharmacy and Technology 2023; 16(7):3405-9. doi: 10.52711/0974-360X.2023.00563
Cite(Electronic):
S. Baataoui, M. Chakit, M. Boudhan, M. Ouhssine. Assessment of Vitamin D, Calcium, Cholesterol, and Phosphorus status in Obese and Overweight patients in Kenitra city (Morocco). Research Journal of Pharmacy and Technology 2023; 16(7):3405-9. doi: 10.52711/0974-360X.2023.00563 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2023-16-7-60
REFERENCES:
1. Renkema KY. Alexander RT. Bindels RJ. Hoenderop JG. Calcium and phosphate homeostasis: concertedinterplay of new regulators. Ann. Med. 2008; 40, 82–91. doi: 10.1080/07853890701689645
2. Peacock M. Calcium metabolism in health and disease. Clin. J. Am. Soc. Nephrol. 2010; 5(Suppl. 1), S23–S30. doi:10.2215/CJN.05910809
3. Shahar DR. et al. Dairy calcium intake, serum vitamin D, and successful weight loss. Am J Clin Nutr. 2010; 92(5): 10171022.doi.org/10.3945/ajcn.2010.29355
4. Subashree R. Radhika Arjunkumar. Vitamin D Deficiency in Periodontal Health. Research J. Pharm. and Tech. 2014; 7(2):248-252.
5. Shapses SA. et al. Vitamin D supplementation and calcium absorption during caloric restriction: a randomized double-blind trial. Am J Clin Nutr. 2013; 97(3): 637-645.doi.org/10.3945%2Fajcn.112.044909
6. Sally Kaddoura, Marwan Alhalabi, Abdul Hakim Nattouf. The effect of Calcium and Vitamin D Supplements as an Adjuvant Therapy to Metformin on Lipid profile in vitamin D Deficient/Insufficient Polycystic Ovary Syndrome Patients. Research J. Pharm. and Tech. 2019; 12(4): 1610-1614.doi.org/10.5958/0974-360X.2019.00268.3
7. Flegal KM. Carroll MD. Ogden CL. Curtin LR. Prevalence and trends in obesity among US adults, 1999-2008. JAMA. 2010 Jan 20;303(3):235-41.doi.org/10.1001/jama.2009.2014
8. MenonA., Thenmozhi MS. Correlation Between Thyroid Function and Obesity. Research J. Pharm. and Tech. 2016; 9(10):1568-1570.doi.org/10.5958/0974-360X.2016.00307.3
9. Mokdad AH.Serdula MK. Dietz WH. Bowman BA. Marks JS. Koplan JP. The spread of the obesity epidemic in the United States, 1991-1998. JAMA. 1999;282(16):1519-22.doi.org/10.1001/jama.282.16.1519
10. Kausar H. Ubaid-Ur-Rahaman M. An Assessment Of Obesity Amongst Working Women. Research J. Pharmacology and Pharmacodynamics. 2013; 5(2): 134-135
11. Shilpa S. Naseeba PP.Princy P.GopikaManoj.Adheena P.Yusra KV.Akhila B Kallada. Relationship between Physical activity and Obesity among female residents in a selected community. Int. J. Nur. Edu. and Research. 2021; 9(1):45-53.doi.org/10.5958/2454-2660.2021.00011.9
12. Afzal S.Brøndum-Jacobsen P.Bojesen SE.Nordestgaard BG. Vitamin D concentration, obesity, and risk of diabetes: a Mendelian randomisation study. Lancet Diabetes Endocrinol. 2014; 2:298–306.doi.org/10.1016/s2213-8587(13)70200-6
13. Rajalakshimi V.VijeyAanandhi M. Hypovitaminosis D Influences Chronic Ailments; Implication for Health. Research J. Pharm. and Tech. 2018; 11(6): 2659-2666.doi.org/10.5958/0974-360X.2018.00493.6
14. Allali F. High prevalence of hypovitaminosis D in Morocco: relationship to lifestyle, physical performance, bone markers, and bone mineral density. Semin Arthritis Rheum. 2009; 38(6):444-51. doi: 10.1016/j.semarthrit.2008.01.009.
15. Thressia PA. (Sr. TresaAnto) ,Rajeev. Kumar N. Effect of Sleep Duration on Obesity and the Glycemic level in Patients with Type 2 Diabetes. Asian J. Nur. Edu. and Research. 2014; 4(4): 502-507.
16. GuaschA. et al. Plasma vitamin D and parathormone are associated with obesity and athero-genic dyslipidemia: a cross-sectional study. Cardiovasc Diabetol. 2012; 11: 149.doi.org/10.1186/1475-2840-11-149
17. Bell NH. Epstein S. Greene A. et al. Evidence for alteration of the vitamin D-endocrine system in obese subjects. J Clin Invest.1985; 76:370–373. doi.org/10.1172%2FJCI111971
18. Liel Y. Ulmer E.Shary J. Hollis BW. Bell NH. Low circulating vitamin D in obesity. Calcif Tissue Int.1988; 43:199–201. doi.org/10.1007/bf02555135
19. Melamed ML, Michos ED, Post W, Astor B. 25-hydroxyvitamin D levels and the risk of mortality in the general population. Arch Intern Med.2008; 168:1629–1637.doi.org/10.1001/archinte.168.15.1629oi:10.1001/archinte.168.15.1629
20. Compston JE.Vedi S.Ledger JE. et al. Vitamin D status and bone histomorphometry in gross obesity. Am J Clin Nutr. 1981; 34:2359–2363. doi.org/10.1093/ajcn/34.11.2359
21. Aldoori NM. Prevalence of Obesity among female Adolescents in Al-Hillah city: Future Risk of Cardiovascular Diseases. Research J. Pharm. and Tech. 2017; 10(7): 2127-2131.doi.org/10.5958/0974-360X.2017.00373.0
22. Parikh SJ. Edelman M.Uwaifo GI. et al. The relationship between obesity and serum 1,25-dihydroxy vitamin D concentrations in healthy adults. J Clin Endocrinol Metab. 2004; 89:1196–1199. doi.org/10.1210/jc.2003-031398
23. Wortsman J. Matsuoka LY. Chen TC. Lu Z.Holick MF. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 2000; 72:690–693.doi.org/10.1093/ajcn/72.3.690
24. Arunabh S. Pollack S. Yeh J.Aloia JF. Body fat content and 25-hydroxyvitamin D levels in healthy women. J Clin Endocrinol Metab. 2003; 88:157–161.doi.org/10.1210/jc.2002-020978
25. Parker J. Hashmi O. Dutton D.Mavrodaris A.Stranges S.Kandala NB. et al. Levels of vitamin D and cardiometabolic disorders: systematic review and meta-analysis. Maturitas. 2010;65:225–36. doi.org/10.1016/j.maturitas.2009.12.013
26. Scragg R.Khaw KT. Murphy S. Effect of winter oral vitamin D3 supplementation on cardiovascular risk factors in elderly adults. Eur J Clin Nutr. 1995;49:640–46.
27. Heikkinen AM.Tuppurainen MT.Niskanen L.Komulainen M. Penttilä I.Saarikoski S. Long-term vitamin D3 supplementation may have adverse effects on serum lipids during postmenopausal hormone replacement therapy. Eur J Endocrinol. 1997;137:495–502. doi.org/10.1530/eje.0.1370495
28. Pfeifer M.Begerow B.Minne HW.Nachtigall D. Hansen C. Effects of a short-term vitamin D(3) and calcium supplementation on blood pressure and parathyroid hormone levels in elderly women. J Clin Endocrinol Metab. 2001;86:1633–7. doi.org/10.1210/jcem.86.4.7393
29. Nagpal J.Pande JN. Bhartia A. A double-blind, randomized, placebo-controlled trial of the short-term effect of vitamin D3 supplementation on insulin sensitivity in apparently healthy, middle-aged, centrally obese men. Diabet Med. 2009;26:19-27.
30. Zittermann A. Frisch S. Berthold HK.Götting C. Kuhn J.Kleesiek K. et al. Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers. Am J Clin Nutr. 2009;89:1321–7.doi.org/10.1111/j.1464-5491.2008.02636.x
31. von Hurst PR. Stonehouse W. Coad J. Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient—a randomised, placebo-controlled trial. Br J Nutr. 2010;103:549–55.
32. Jorde R.Sneve M.Torjesen P. Figenschau Y. No improvement in cardiovascular risk factors in overweight and obese subjects after supplementation with vitamin D3 for 1 year. J Intern Med. 2010;267:462–72.doi.org/10.1017/s0007114509992017
33. Lenders CM. Feldman HA. Von Scheven E et al. Relation of body fat indexes to vitamin D status and deficiency among obese adolescents. Am J Clin Nutr. 2009; 90:459–467.doi.org/10.3945%2Fajcn.2008.27275
34. Moschonis G. Tanagra S.Koutsikas K. et al. Association between serum 25-hydroxyvitamin D levels and body composition in postmenopausal women: the postmenopausal Health Study. Menopause. 2009; 16:701-707. doi.org/10.1097/gme.0b013e318199d5d5
35. Kimmons JE.Blanck HM.Tohill BC. Zhang J. Khan LK. Associations between body mass index and the prevalence of low micronutrient levels among US adults. MedGenMed. 2006; 8:59
36. Reinehr T. et al. "FRE F Vitamin D status and parathyroid hormone in obese children before and after weight loss." European Journal of Endocrinology. 2007; 157(2): 225-232. doi.org/10.1530/eje-07-0188
37. Looker AC. Body fat and vitamin D status in black versus white women. J Clin Endocrinol Metab. 2005; 90:635–640.doi.org/10.1210/jc.2004-1765
38. Schrager S. Dietary calcium intake and obesity. J Am Board Fam Pract. 2005; 18:205–210.doi.org/10.3122/jabfm.18.3.205
39. Snijder MB.van Dam RM. Visser M. et al. Adiposity in relation to vitamin D status and parathyroid hormone levels: a population-based study in older men and women. J Clin Endocrinol Metab. 2005; 90:4119–4123. doi.org/10.1210/jc.2005-0216
40. Monalisa R. Role of Leptin in obesity. Research J. Pharm. and Tech. August 2015;8(8):1073-1076.doi.org/10.7326/0003-4819-130-8-199904200-00014
41. Gretchen AS. et al. National, regional, and global trends in adult overweight and obesity prevalences. Population Health Metrics. 2012; 22(10): 1-16.doi.org/10.1186%2F1478-7954-10-22
42. Kanchana K. A Descriptive Study to Assess the Prevalence of Obesity among women in an urban area of selected city. Asian Journal of Nursing Education and Research. 2021; 11(3):384-6. doi.org/10.52711/2349-2996.2021.00092
43. Cheng S.Massaro JM. Fox CS.et al. Adiposity, cardiometabolic risk, and vitamin D status: the Framingham Heart Study. Diabetes. 2010; 59:242–248. doi.org/10.2337/db09-1011
44. Vimaleswaran KS. et al. Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts. PLoS Med. 2013; 10(2): e1001383.doi.org/10.1371/journal.pmed.1001383
45. Muscogiuri G.Sorice GP.Prioletta A. et al. 25-Hydroxyvitamin D concentration correlates with insulin-sensitivity and BMI in obesity. Obesity (Silver Spring). 2010; 18:1906–1910. doi.org/10.1038/oby.2010.11
46. Afzal S.Brøndum-Jacobsen P.Bojesen SE.Nordestgaard BG. Vitamin D concentration, obesity, and risk of diabetes: a mendelian randomisation study. Lancet Diabetes Endocrinol. 2014 Apr;2(4):298-306.https://doi.org/10.1016/s2213-8587(13)70200-6