Author(s):
Gulzira Izmukhanovna Yernazarova, Aliya Amangeldievna Ramazanova, Svetlana Kazbekovna Turasheva, Faisal A. Almalki, Taibi Ben Hadda, Saltanat Bolatovna Orazova, Aigul Kalikhozhaevna Madenova, Gulnur Bolatovna Admanova, Dmitry Yuryevich Korul'kin, Gulnarai Musuralievna Sabdenalieva, Souad Naimi, Zhanat Bukharbayeva, Madina Erbolkyzy Amangeldinova
Email(s):
gulzira.yernazarova@bk.ru
DOI:
10.52711/0974-360X.2023.00564 
Address:
Gulzira Izmukhanovna Yernazarova1*, Aliya Amangeldievna Ramazanova2, Svetlana Kazbekovna Turasheva1, Faisal A. Almalki3, Taibi Ben Hadda4, Saltanat Bolatovna Orazova1, Aigul Kalikhozhaevna Madenova5, Gulnur Bolatovna Admanova6, Dmitry Yuryevich Korul'kin1,Gulnarai Musuralievna Sabdenalieva7, Souad Naimi8, Zhanat Bukharbayeva1, Madina Erbolkyzy Amangeldinova1
1Al -Faraby Kazakh National University, Almaty, 050040, Republic of Kazakhstan.
2Kazakh National Women's Teacher Training University, Almaty, 050000, Republic of Kazakhstan.
3Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Umm AlQura University, Makkah, 21955, Saudi Arabia.
4ACE Laboratory, FSO, Mohammed Premier University, Oujda, 60000, Morocco.
5Kazakh National Agrarian Research University, Almaty, 050010, Republic of Kazakhstan.
6K. Zhybanov Aktobe Regional University, Aktobe, 030000, Republic of Kazakhstan.
7Abai Kazakh National Pedagogical University, Almaty, 050010, Republic of Kazakhstan.
8Depart
Published In:
Volume - 16,
Issue - 7,
Year - 2023
ABSTRACT:
Currently, during the period of intensive development of scientific production, it is important to obtain phytopreparations from sources of raw materials of plant origin. The biological diversity of plants is amazing. The study of the composition of aquatic plants rich in active substances of biotechnological significance is currently an urgent problem. Biologically active substances are involved in various regenerative reactions and metabolic processes in the organism, being part of enzymes. Alkaloids are important nitrogenous compounds found in the plant and are widely used in medicine. The aim of the present study was to identify alkaloid compounds from the composition of the aquatic plant Pistia stratiotes, grown in a model experiment in laboratory conditions by highly effective liquid chromatography and determine the molecular structure by nuclear magnetic resonance. In addition, based on the molecular structure of alkaloid compounds found in the aquatic plant Pistia stratiotes, a study of the properties of pharmaceutical activity was conducted on the pharmaceutical site POM (Petra/Osiris/Molinspiration). According to the results of the study, 4 types of identified alkaloids were identified by the IR, 1H, 13C-NMR method. They: 1-Aza-10-methoxy-4-methyl-2-oxo-1,2-dihydroanthracene-9-O-b-D-glucopyranoside, 4,6-dimethoxy-8-prenyloxyfuroquinoline, 4,7-dimethoxy-6 - (3’ - methyl-3’ - methoxy-2 ' - oxy) butyl-oxifuroquinoline , 4,7-dimethoxy-6 - (3’ - methyl-2’ - oxy-3 ' - chlorine)butyloxifuroquinoline. As a result of the analysis of the identified POM alkaloids (Petra/Osiris/Molinspiration), predictions of antitumor activity were made. The presence of a (NHd+--- Od-) moiety indicates a potential antitumor pharmacophore site. The challenge is to verify our hypothesis experimentally and to confront virtual POM data and real anticancer screening.
Cite this article:
Gulzira Izmukhanovna Yernazarova, Aliya Amangeldievna Ramazanova, Svetlana Kazbekovna Turasheva, Faisal A. Almalki, Taibi Ben Hadda, Saltanat Bolatovna Orazova, Aigul Kalikhozhaevna Madenova, Gulnur Bolatovna Admanova, Dmitry Yuryevich Korul'kin,Gulnarai Musuralievna Sabdenalieva, Souad Naimi, Zhanat Bukharbayeva, Madina Erbolkyzy Amangeldinova. Extraction, Purification and Characterisation of four new alkaloids from the water plant Pistia stratiotes: POM Analyses and Identification of Potential Pharmacophore Sites. Research Journal of Pharmacy and Technology 2023; 16(7):3410-6. doi: 10.52711/0974-360X.2023.00564
Cite(Electronic):
Gulzira Izmukhanovna Yernazarova, Aliya Amangeldievna Ramazanova, Svetlana Kazbekovna Turasheva, Faisal A. Almalki, Taibi Ben Hadda, Saltanat Bolatovna Orazova, Aigul Kalikhozhaevna Madenova, Gulnur Bolatovna Admanova, Dmitry Yuryevich Korul'kin,Gulnarai Musuralievna Sabdenalieva, Souad Naimi, Zhanat Bukharbayeva, Madina Erbolkyzy Amangeldinova. Extraction, Purification and Characterisation of four new alkaloids from the water plant Pistia stratiotes: POM Analyses and Identification of Potential Pharmacophore Sites. Research Journal of Pharmacy and Technology 2023; 16(7):3410-6. doi: 10.52711/0974-360X.2023.00564 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2023-16-7-61
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