Author(s):
Manish Singh, Brijesh Kumar, Alok K Singh, Chandra Shekhar Azad, Mukesh K Yadav, Ashutosh Kumar, Rajesh Kumar, Ajay Kumar, Pritee Chaudhary
Email(s):
asthwal@rediffmail.com
DOI:
10.52711/0974-360X.2023.00566 
Address:
Manish Singh1, Brijesh Kumar1*, Alok K Singh2, Chandra Shekhar Azad2, Mukesh K Yadav3, Ashutosh Kumar1, Rajesh Kumar1, Ajay Kumar1, Pritee Chaudhary2
1Department of Pharmacology, Institute of Medical Sciences, BHU, Varanasi, India.
2Department of Medicine, Institute of Medical Sciences, BHU, Varanasi, India.
3Vaccine and Infectious Disease Research Center, Translational Health Science and Technology Institute, Faridabad, Haryana, India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 7,
Year - 2023
ABSTRACT:
The pharmacokinetic parameters of a drug plays a very essential role in determining the therapeutic success of an experimental compound, so it is one of the aspects of drug discovery which are essential to be determined in the early phases. The pharmacokinetic studies further help the drug discovery team to optimize their in vivo pharmacokinetic and drug safety bioassays.Low solubility, low absorbency, and chemical instability can seriously affect bioassay results. Today a lot of computational software are available which use their algorithms to calculate the pharmacokinetic parameters of the selected compounds and hence may help the drug discovery team to move in a direction where the chances of getting a good clinical candidate are higher. This paper presents the screening of nine selected herbal anticancer agents (Catechin, Cinnamaldehyde, Epicatechin, Eugenol, Oxyresveratrol, Quercetin, Crocin, Kaempferol, and Emodin) based upon their pharmacokinetic properties with the help of Discovery Studio 2.5. The main parameters which are estimated under this pharmacokinetic ADMET (absorption, distribution, metabolism, excretion and toxicity) study are aqueous solubility, human intestinal absorption, plasma protein binding (PPB), blood-brain-barrier (BBB) penetration, cytochrome P4502D6 inhibition and hepatotoxicity levels. Four compounds (Cinnamaldehyde, Eugenol, Crocin and Oxyresveratrol) were found to possess the required pharmacokinetic properties and are suitable for further anticancer in vivo and in vitro analysis.
Cite this article:
Manish Singh, Brijesh Kumar, Alok K Singh, Chandra Shekhar Azad, Mukesh K Yadav, Ashutosh Kumar, Rajesh Kumar, Ajay Kumar, Pritee Chaudhary. Pharmacokinetic screening to Estimate the drug likeliness characteristics of selected Herbal Anticancer Drugs. Research Journal of Pharmacy and Technology 2023; 16(7):3422-6. doi: 10.52711/0974-360X.2023.00566
Cite(Electronic):
Manish Singh, Brijesh Kumar, Alok K Singh, Chandra Shekhar Azad, Mukesh K Yadav, Ashutosh Kumar, Rajesh Kumar, Ajay Kumar, Pritee Chaudhary. Pharmacokinetic screening to Estimate the drug likeliness characteristics of selected Herbal Anticancer Drugs. Research Journal of Pharmacy and Technology 2023; 16(7):3422-6. doi: 10.52711/0974-360X.2023.00566 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2023-16-7-63
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