Author(s): Juliana Leiwakabessy, Yahya, Mohammad Fadjar, Eddy Suprayitno

Email(s): j.leiwakabessy@unipa.ac.id

DOI: 10.52711/0974-360X.2023.00689   

Address: Juliana Leiwakabessy1,3, Yahya2, Mohammad Fadjar2, Eddy Suprayitno2
1Doctor Program, Faculty of Fsheries and Marine Science, University of Brawijaya, Malang, East Java, Indonesia.
2Faculty of Fisheries and Marine Science, University of Brawijaya, Malang, East Java, Indonesia.
3Faculty of Fisheries and Marine Science, Papua University, Manokwari 98314, West Papua, Indonesia.
*Corresponding Author

Published In:   Volume - 16,      Issue - 9,     Year - 2023


ABSTRACT:
Tambelo reportedly has a positive impact on health. Our study investigates the possible effect of tambelo extract as an anti-inflammatory in mice induced by lipopolysaccharide(LPS)Tambelo phytochemistry from liquid chromatography analysis – high-resolution mass spectrometry (LCMS) coupled with NF-?B protein, docking was carried out to pursue anti-inflammatory properties. Thirty Balb/C mice were randomized into six groups: untreated, LPS, dexamethasone + LPS, and tambelo extract with doses of 100, 150, and 200 mg/kg BW + LPS, respectively. The results of this study indicate that there are four compounds which has a high affinity for the target protein. High CD4+CD25+ expression after treatment with fermented products tambelo (BE) significantly attenuated LPS-induced mice (p<0.05). Our findings show that fermentation tambelo protects against induced LPS by maintaining Tregs. Tambelo may have the potential as a food choice due to its anti-inflammatory properties.


Cite this article:
Juliana Leiwakabessy, Yahya, Mohammad Fadjar, Eddy Suprayitno. The Role of Tambelo Extract (Bactronophorus thoracites) in Mice-Induced Lipopolysaccharide: Food Health Benefits. Research Journal of Pharmacy and Technology 2023; 16(9):4213-8. doi: 10.52711/0974-360X.2023.00689

Cite(Electronic):
Juliana Leiwakabessy, Yahya, Mohammad Fadjar, Eddy Suprayitno. The Role of Tambelo Extract (Bactronophorus thoracites) in Mice-Induced Lipopolysaccharide: Food Health Benefits. Research Journal of Pharmacy and Technology 2023; 16(9):4213-8. doi: 10.52711/0974-360X.2023.00689   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2023-16-9-33


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