Author(s):
Siti Wakhidatun Suciyati, Sukrasno, Neng Fisheri Kurniati, I Ketut Adnyana
Email(s):
ketut@fa.itb.ac.id , swsuciyati@s.itb.ac.id
DOI:
10.52711/0974-360X.2024.00754 
Address:
Siti Wakhidatun Suciyati1,2*, Sukrasno3, Neng Fisheri Kurniati1, I Ketut Adnyana1*
1Department of Pharmacology, School of Pharmacy, Institut Teknologi Bandung, Ganeca Street 10 Bandung 40132, Indonesia.
2Department of Pharmacology, Indonesian School of Pharmacy, Soekarno Hatta Street 354, Bandung 40266, Indonesia.
3Department of Pharmaceutical Biology, School of Pharmacy, Institut Teknologi Bandung, Ganeca Street 10 Bandung 40132, Indonesia.
*Corresponding Author
Published In:
Volume - 17,
Issue - 10,
Year - 2024
ABSTRACT:
Atherosclerosis is a systemic disease, a combination of inflammatory conditions, endothelial dysfunction, and theaccumulation of lipids to form plaques in blood vessels. The inflammatory environment within the atherosclerotic lesion stimulates the lipoxygenase pathway of arachidonic acid metabolism, resulting in biosynthesis of the potent lipid inflammatory mediator. Our previous study showed fractions collected from n-hexane extract of red ginger rhizome has potential as NF-?B pathway inhibitor. This study aimed to examine its anti-inflammatory activity in macrophage cells and its effect on the lipoxygenase pathway also determined its metabolite profiles by gas chromatography–mass spectrometry (GC-MS) method. Results showed fraction F6 from red ginger n-hexane extract is a potent inhibitor of the lipoxygenase enzyme (IC50 36.40 ± 0.76 µg/ml), reduces the release of TNF-a and IL-6 cytokines, and inhibits lipid peroxidation(IC50 45.97 ± 5.14µg/ml).Not only high in 6-gingerol (194,99 ± 1,43mg/g extract), this fraction also contains zingerone, 6-paradol, and 6-shogaol which have been shown to have anti-inflammatory effects.
Cite this article:
Siti Wakhidatun Suciyati, Sukrasno, Neng Fisheri Kurniati, I Ketut Adnyana. Bioactive substances from Red ginger rhizome (Zingiber officinale Roscoe var. sunti Val) as Anti-atherosclerotic agent: Inhibition of Lipoxygenase in arachidonic acid metabolism. Research Journal of Pharmacy and Technology. 2024; 17(10):4901-6. doi: 10.52711/0974-360X.2024.00754
Cite(Electronic):
Siti Wakhidatun Suciyati, Sukrasno, Neng Fisheri Kurniati, I Ketut Adnyana. Bioactive substances from Red ginger rhizome (Zingiber officinale Roscoe var. sunti Val) as Anti-atherosclerotic agent: Inhibition of Lipoxygenase in arachidonic acid metabolism. Research Journal of Pharmacy and Technology. 2024; 17(10):4901-6. doi: 10.52711/0974-360X.2024.00754 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2024-17-10-39
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