Author(s):
Mini Dahiya, Monu Yadav, Sumit Kumar, Shilpi Chauhan, Deepak Lamba
Email(s):
monuyadav.pharmacology@gmail.com , drsumitkumar@cuh.ac.in
DOI:
10.52711/0974-360X.2024.00724 
Address:
Mini Dahiya1, Monu Yadav2*, Sumit Kumar3*, Shilpi Chauhan4, Deepak Lamba5
1University Institute of Pharmaceutical Sciences (UIPS), UGC Centre for Advanced Study Panjab University, Chandigarh -160014 (Panjab), India.
2Amity Institute of Pharmacy, Amity University, Haryana, Amity Education Valley Gurugram, Manesar, Panchgaon, Haryana, India.
3Department of Pharmaceutical Sciences, Central University of Haryana, Jant - Pali Mahendergarh - 123031, Haryana, India.
4Department of Pharmacy, Lloyd Institute of Management and Technology, Plot No.-11, Knowledge Park-II, Greater Noida, Uttar Pradesh, 201306, India.
5Central Council for Research in Ayurvedic Sciences, Janakpuri, New Delhi-India.
*Corresponding Author
Published In:
Volume - 17,
Issue - 10,
Year - 2024
ABSTRACT:
This paper aims to study the phytochemical analysis of Buchanania lanzan oil and the anticancer property of its PEG-coated chitosan nanoformulation. The GC-MS analysis of Buchanania lanzan oil showed 24 compounds. In literature, pharmacology active compounds like ß –sitosterol, stigmasterol, sitosterol, fucosterol, campesterol, stearic acid, tocopherol, ?-tocopherol, squalene, n-hexadecanoic acid, and palmitic acid reported to have a therapeutic effect on cancerous cells. 32 factorial design is a type of experimental design, was utilized to optimize the nanoformulation to achieve maximum entrapment efficiency and minimum particle size. Independent factors were the chitosan and PEG concentration while dependent factors were entrapment efficiency and particle size. The optimized Buchanania lanzan oil encapsulated nanoformulation (BOCNo) has a particle size of 490.18 nm and entrapment efficiency of 59.08%. Buchanania lanzan oil and optimized BOCNo has shown significant anticancer activity against prostate cancer (PC3), lung cancer (A549), and liver cancer (MIAPACA) cell lines having IC 50 value of 9.03g/ml, 7.50g/ml, and 15.63g/ml and 11.84g/ml, 19.50g/ml, and 17.09g/ml respectively. Anticancer effect of PEG-coated nanoformulations of Buchanania lanzan oil attributed to better penetration by increased permeability and fusion of drug molecules. Buchanania lanzan oil and BOCNo have a promising cytotoxic potential against prostate cancer, lung cancer, and liver cancer by owning the presence of therapeutically active compounds which synergistically act via multiple protective mechanisms.
Cite this article:
Mini Dahiya, Monu Yadav, Sumit Kumar, Shilpi Chauhan, Deepak Lamba. GC–MS Analysis and Fabrication of Nanoparticles of Buchanania lanzan oil for the Anticancer activity. Research Journal of Pharmacy and Technology. 2024; 17(10):4699-6. doi: 10.52711/0974-360X.2024.00724
Cite(Electronic):
Mini Dahiya, Monu Yadav, Sumit Kumar, Shilpi Chauhan, Deepak Lamba. GC–MS Analysis and Fabrication of Nanoparticles of Buchanania lanzan oil for the Anticancer activity. Research Journal of Pharmacy and Technology. 2024; 17(10):4699-6. doi: 10.52711/0974-360X.2024.00724 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2024-17-10-9
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