Author(s): P.A. Panmand, P. R. Mahaparale, V. P. Thorat

Email(s): priyankapanmand92@gmail.com

DOI: 10.52711/0974-360X.2024.00157   

Address: P.A. Panmand1*, P. R. Mahaparale2, V. P. Thorat3
1Indrayani Institute of Pharmaceutical Education and Research, Talegaon, Dabhade.
2Government College of Pharmacy, Osmanpura Aurangabad, Maharashtra, India – 431005.
3Siddhi College of Pharmacy Chikhali, Pune, Maharashtra 411062.
*Corresponding Author

Published In:   Volume - 17,      Issue - 3,     Year - 2024


ABSTRACT:
In order to understand the in vitro drug release of the produced gel, the goal of the current investigation was to construct and characterize. Acitretin loaded Solid Lipid Nanoparticles (ActSLNs). Act SLNs were created utilizing the Box Benhken design and the hot homogenization procedure. Act SLN's average diameter and surface morphology were assessed. Act SLNs were lyophilized, then they underwent stability testing, powder X-Ray diffraction, Differential Scanning Calorimetry (DSC), and Fourier Transform Infrared (FT-IR) tests to characterize them. The SLNs were added to a 0.25% w/w Carbopol 940 gel base the Stability study, ex vivo drug release in vitro drug releases in rat skin were carried out. The optimized Act SLNs had a spherical form, an entrapment efficiency of 78.82% to 85.73%, and an average particle size of 123.24nm to 409nm. The generation of SLNs was confirmed by DSC, FTIR, and XRD data. ActSLN gel (0.056mg/cm2) significantly increased the amount of accutane deposited in rat skin compared to Act plain gel (0.012mg/cm2).No discernible change was found in the stability studies, according to stability studies.


Cite this article:
P.A. Panmand, P. R. Mahaparale, V. P. Thorat. Development and Evaluation of Acitretin Loaded Solid Lipid Nanoparticles for Topical Drug Delivery System. Research Journal of Pharmacy and Technology. 2024; 17(3):1015-2. doi: 10.52711/0974-360X.2024.00157

Cite(Electronic):
P.A. Panmand, P. R. Mahaparale, V. P. Thorat. Development and Evaluation of Acitretin Loaded Solid Lipid Nanoparticles for Topical Drug Delivery System. Research Journal of Pharmacy and Technology. 2024; 17(3):1015-2. doi: 10.52711/0974-360X.2024.00157   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2024-17-3-8


REFERENCES:
1.    Kakadia P., Conway B. Solid lipid nanoparticles: A Potential Approach for Dermal Drug Delivery, American Journal of Pharmacological Sciences, 2014; 2(5): 1-7. Doi 10.4103/0250-474X.57282
2.    Kuchekar A., Pujari   R. Psoriasis: A comprehensive review, International Journal of Pharmacy and Life sciences. 2011; 2(6): 857- 877.DOI: 10.2174/1574886315666200128095958
3.    Paliwal R., Paliwal S. Solid lipid nanoparticles: a revive on recent perspective, National Library of Medicine. 2020; 2(1): 80-102. doi: 10.1080/13543776.2020.1720649.
4.    Powar P., Sharma P. Solid Lipid Nanoparticles: Budding field of Lipid Nanotechnology. Critical Review in Pharmaceutical Sciences. 2013; 3(2): 1-11. doi: 10.1080/13543776.2013.1720649.
5.    Patel R., Singhal B. Solid Lipid Nanoparticlesand nanocarriers:As novel solid  lipid based drug carrier. International Research Journal of Pharmacy. 2011; 2(2): 40-52. https://doi.org/10.1016/j.jt.2011.104709
6.    Pandya J., Parmar R. Solid Lipid Nanoparticles: Overview on Excipients. Asian Journal of Pharmaceutical Technology & Innovation. 2013; 1 (3): 1-9.  https://doi.org/10.3390/antiox12030633
7.    Mahajan A. Kaur S. Solid lipid nanoparticles (SLNs): As novel lipid based nanocarriers for drugs. International Journal of Advanced Research. 2014; 2(1): 433-441. https://doi.org/10.3389/fmolb.2014.587997
8.    Hajare A., Salunkhe S. Lipid nanoparticles: A modern formulation approach in topical drug delivery systems Journal of Advanced Drug Delivery. 2014; 1(1): 30-37. DOI: 10.7324/JAPS.2014.601017
9.    Karimulla S. Solid lipid nanoparticles -A brief review International Journal of Advanced Pharmaceutics. 2012; 2(1): 35-55. DOI:10.2174/2210681209666190218143736
10.    Garud A. Solid lipid nanoparticles (SLN): method, characterization and applications. International Current Pharmaceutical Journal. 2012; 1(11): 384-393.https://doi.org/10.1248/cpb.58.650
11.    Yadav P. Solid lipid nanoparticles: an effective and promising drug delivery system- a review. International Journal of Pharmaceutical Journal and Research.  2014; 5(4): 1152-1162.DOI: 10.2174/1875933501704010017
12.    Sarathchandiran I. A review on nanotechnology in solid lipid nanoparticles. International Journal of Pharmaceutical Development and Technology. 2012; 2(1): 45-61. https://doi.org/10.1016/j.jsps.20212.04.007
13.    Khare A. Design and evaluation of Voriconazole loaded solid lipid nanoparticles for ophthalmic application. International Journal of Pharmaceutical Journal and Research. 2016; 2(5): 145-150. DOI: 10.23893/1307-2080.APS.05616
14.    Uner M. Solid lipid nanoparticles and nanostructure lipid carrier for Loratadine for topical application physicochemical stability and drug penetration through rat skin. Tropical Journal of Pharmaceutical Research. 2014; 13(5): 653-660. 10.5958/0975-4377.2016.00011.2
15.    Found E. Characterization of Celecoxib loaded solid lipid nanoparticle formulated with Tristearin and Softisan 100. Tropical Journal of Pharmaceutical Research. 2015; 14(2): 205-210. https://doi.org/10.1155/2013/584549
16.    Rondero A. Solid lipid nanoparticles and nanostructure lipid carrier occlusive effect and penetration enhancement ability. Journal of Cosmatics and Dematological Sciences and Application 2015,5,62 -72.
17.    Shah P. Formulation and optimization of Rosuvastatin Calcium loaded solid lipid nanoparticle by 32 full factorial designs, Nano World Journal. 2015; 110-119. https://doi.org/10.37285/ijpsn.2019.12.2.1
18.    Gaffari S. Sustained release Curcumin loaded solid lipid nanoparticle.  Advance Pharmaceutical Bulletin. 2016; 6(1): 17-21. DOI: 10.5958/0974-360X.2016.00051.2
19.    Garg A. Targeting of eugenol loaded solid lipid nanoparticles to the epidermal layer of human skin.  2013; 3(7): 201- 206 DOI: https://doi.org/10.22159/ijap.2013v15i6.48971
20.    Sanna V. Effect of lipid nanoparticles containing fatty alcohols having different chain length on the ex vivo skin permeability of Econazole nitrate. Powder Technology. 2010: 32-36. https://doi.org/10.1590/s2175-97902017000115012

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available