Author(s):
Viol Dhea Kharisma, Arif Nur Muhammad Ansori, Ahmad Affan Ali Murtadlo, Maksim Rebezov, Nikolai Maksimiuk, Pavel Burkov, Marina Derkho, Elena Bobkova
Email(s):
hery-p@fst.unair.ac.id
DOI:
10.52711/0974-360X.2024.00282 
Address:
Viol Dhea Kharisma1,2, Arif Nur Muhammad Ansori1,3, Ahmad Affan Ali Murtadlo2, Maksim Rebezov4,5, Nikolai Maksimiuk6, Pavel Burkov7, Marina Derkho7, Elena Bobkova8,
Evgeny Ponomarev8, Vikash Jakhmola9, Hery Purnobasuki1,10*
1Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.
2Computational Virology Research Unit, Division of Molecular Biology and Genetics, Generasi Biologi Indonesia Foundation, Gresik, Indonesia.
3Professor Nidom Foundation, Surabaya, Indonesia.
4Department of Scientific Research, V. M. Gorbatov Federal Research Center for Food Systems, Moscow, Russian Federation.
5Faculty of Biotechnology and Food Engineering, Ural State Agrarian University, Yekaterinburg, Russian Federation.
6Institute of Medical Education, Yaroslav-the-Wise Novgorod State University, Velikiy Novgorod, Russian Federation.
7Institute of Veterinary Medicine, South Ural State Agrarian University, Troitsk, Russian Federation.
8K.G. Razum
Published In:
Volume - 17,
Issue - 4,
Year - 2024
ABSTRACT:
Human immunodeficiency virus (HIV) is a genus of Lentivirus that triggers opportunistic diseases in the human body. HIV-1 has been a major problem for the world community for a long time and triggered a pandemic. HIV-1 antiviral drugs with the mechanism of inhibiting specific proteins have been found but have some harmful side effects for patients. Back to nature solutions can be used to solve these problems. Natural ingredients can be used as an alternative treatment for the treatment of HIV-1 infection allegedly more effective and minimal side effects. Antiviral candidate natural ingredients such as Garcinia mangostana L. with compounds consisting of Mangostin and Garcinone, the potential of Garcinone compounds is currently still unidentified. This study aims to reveal the potential of Garcinone derivative compounds from Garcinia mangostana L. as HIV-1 antiviral through the mechanism of reverse transcriptase inhibition with an in silico approach. The method used in this research is in silico simulation such as druglikeness analysis, molecular docking, chemical bond identification, and molecular stability. Garcinone A from Garcinia mangostana L. can be an HIV-1 antiviral candidate with a good molecular mechanism of inhibiting HIV-1 RT activity because it produces more negative binding affinity than the control drug and triggers stable binding interactions on the target.
Cite this article:
Viol Dhea Kharisma, Arif Nur Muhammad Ansori, Ahmad Affan Ali Murtadlo, Maksim Rebezov, Nikolai Maksimiuk, Pavel Burkov, Marina Derkho, Elena Bobkova. Revealing Novel Antiretroviral Candidate from Garcinia mangostana L. againts HIV-1 Infection via Reverse Transcriptase Inhibition: In Silico Study. Research Journal of Pharmacy and Technology.2024; 17(4):1777-3. doi: 10.52711/0974-360X.2024.00282
Cite(Electronic):
Viol Dhea Kharisma, Arif Nur Muhammad Ansori, Ahmad Affan Ali Murtadlo, Maksim Rebezov, Nikolai Maksimiuk, Pavel Burkov, Marina Derkho, Elena Bobkova. Revealing Novel Antiretroviral Candidate from Garcinia mangostana L. againts HIV-1 Infection via Reverse Transcriptase Inhibition: In Silico Study. Research Journal of Pharmacy and Technology.2024; 17(4):1777-3. doi: 10.52711/0974-360X.2024.00282 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2024-17-4-56
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