Author(s): Deshmane Gorakh, Dhawale Shashikant, Dhonde Satish

Email(s): gorakh.deshmane.gd@gmail.com

DOI: 10.52711/0974-360X.2024.00324   

Address: Deshmane Gorakh*, Dhawale Shashikant, Dhonde Satish
School of Pharmacy, S.R.T.M. University, Nanded - 431606, MS, India.
*Corresponding Author

Published In:   Volume - 17,      Issue - 5,     Year - 2024


ABSTRACT:
The principal objective of this study is to make and survey the properties of Gel containing terbinafine hydrochloride (TH) stacked niosomal gel by functionalized tamarind involving that might work as effective antifungal medication conveyance frameworks (DDS) for the helpful treatment of contagious contaminations by postponing the prescription delivery. Utilizing a characteristic direct functionalized polymer and the ethanol infusion strategy, niosomal gel was made (thionatinated and sulphonated tamarind). TH stacked niosomal scattering of size going from 100 to 627nm and percent ensnarement effectiveness of 63 to 87% were acquired. Both the factors for example length 60 and cholesterol impact the molecule size and EE (%). In-vitro discharge concentrates on completed in PBS (pH 5.5) for N4 and showcased cream displayed an arrival of 82.72% and 74.92% separately more than 24hr. The details of the Nanosponges were assessed for their rates of creation yield (PY), entanglement effectiveness (EE), and medication stacking (%DL). FTIR, DSC and PXRD studies uncovered that the greater part of the medication was scattered all through the niosomes. DSC and XRD concentrates on additionally shown that medication was in undefined state in the N4 cluster while unadulterated TH was in translucent state. FESEM, TEM and AFM pictures showed that niosomes had round shape with smooth surface. CLSM picture demonstrated the smooth and bilayer design of niosomes. 1%w/v TH (0.1%) stacked niosomal Sulphonated and thionated tamarindgel were ready and portrayed for consistency studies. The consistency of fake treatment Sulphonated and thionated tamarind and TH stacked niosomal gels with both were viewed as 20,500cps, 43,000cps, 10,300cps and 34,600cps respectively. It was apparent from the pH and spreadability boundaries that the fake treatment and TH stacked niosomal gels are viable for skin delivery.In-vitro discharge concentrates on did in PBS (pH 5.5) for THNTT gel, THNST gel and showcased cream wereshowed 74.92±0.98 %,99.07±1.03% and 101.02±0.87% discharge toward the finish of 24 hr respectively.Amount of medication held in skin after 24 hr was 47.68 for THNTT gel while for promoted gel, it was viewed as 27.67 showing THNTT has great skin maintenance properties than advertised cream (Texifen).CLSM investigation of Wistar rodent skin uncovered that niosomes were circulated all through skin with high fluorescence power which ready to help ex vivo skin penetration and maintenance result.No indications of disturbance were seen upon the utilization of fake treatment gel, N4 niosomal scattering, THNTT gel, and advertised cream of TH to the Wistar rodents skin ,affirming that pre-arranged N4 niosomal scattering as well as THNTT gel are liberated from irritation. In vitro antifungal movement study for THNTT gel and showcased cream were performed for both Aspergillusniger (ATCC 10578) and Candida albicans (CA14, clinical confine) and results showed that N4 gel would be advised to antifungal action in contrast with promoted cream.In vivo pharmacodynamic concentrates on showed that THNTT gel lessens parasitic weight or count more actually than advertised cream.


Cite this article:
Deshmane Gorakh, Dhawale Shashikant, Dhonde Satish. Design and Evaluate Terbinafine Hydrochloride Loaded gel by using Modified Tamarind for Topical Drug Delivery. Research Journal of Pharmacy and Technology. 2024; 17(5):2043-0. doi: 10.52711/0974-360X.2024.00324

Cite(Electronic):
Deshmane Gorakh, Dhawale Shashikant, Dhonde Satish. Design and Evaluate Terbinafine Hydrochloride Loaded gel by using Modified Tamarind for Topical Drug Delivery. Research Journal of Pharmacy and Technology. 2024; 17(5):2043-0. doi: 10.52711/0974-360X.2024.00324   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2024-17-5-20


REFERENCES:
1.    http://www.pharmatutor.org/articles/novel-drug-delivery system.
2.    Ashni Verma. Topical gels as drug delivery systems: A review. International Journal of Pharmaceutical Sciences Review and Research. 2013; 23(2):374-382.
3.    Gaba B., Fazil M., Khan S., Ali S., Baboota S. and Ali J. Nanostructured lipid carrier system for topical delivery of terbinafine hydrochloride. Bulletin of Faculty of Pharmacy, Cairo University. 2015; 53: 147–159.
4.    Sara M. AbdelSamie ,Amany O. Kamel , Omaima A. Sammour , Shady M. Ibrahim. Terbinafine hydrochloride nanovesicular gel: In vitro characterization,ex vivo permeation and clinical investigation. European Journal of Pharmaceutical Sciences. 2016; 88: 91–100.
5.    Janaa S., Alib S. A., Nayak A.K., Sena K.K. and Basud S.K. Development of topical gel containingaceclofenac-crospovidone solid dispersion by“Quality by Design (QbD)” approach. Chemical Engineering Research and Design, 2014, CHERD-1484; No. of Pages 11.
6.    Gaba B., Fazil M., Khan S., Ali S., Baboota S. and Ali J. Nanostructured lipid carrier system for topical delivery of terbinafine hydrochloride. Bulletin of Faculty of Pharmacy, Cairo University. 2015; 53: 147–159.
7.    Parsuram RR, Kharkate PR, Thangavel SK. Detailing of aceclofenac supported discharge lattice tablet utilizing hydrophillic normal gum. Bury J Res Ayur Pharm. 2011; 2(3): 851-57
8.    Minghui Fan, ShiyingXu, Shuqin Xia and Xiaoming Zhang, Preparation of salidrosidenano-liposomes by ethanol injection method and in vitro release study. Eur Food Res Technol.  2008; 27: 167–174.
9.    Kumar A., Badde S, Kamble R. and Pokharkar V.B. Development and Characterization of Liposomal Drug Delivery System ForNimesulide. International Journal of Pharmacy and Pharmaceutical Sciences. 2010; 2(4).
10.    Kaur H, Yadav S, Ahuja M et al. Combination, portrayal and assessment of thiolated tamarind seed polysaccharide as a mucoadhesive polymer. Carb Polymers. 2012; 90: 1543-49.
11.    Harmanmeet Kaura, Shikha Yadavb, Munish Ahujab, NeerajDilbaghi, Synthesis, characterization and evaluation of thiolated tamarind seed polysaccharide as a mucoadhesive polymer. Carbohydrate Polymers. 2012;  90: 1543– 1549.
12.    Ruozi B., Tosi G., Tonelli M., Bondioli L., Mucci A., ForniF. and Vandelli M.A. AFM phase imaging of soft-hydrated samples: A versatile tool to complete the chemical-physical study of liposomes. Journal of Liposome Research. 2009; 19(1): 59–67.
13.    Lingan M.A., Sathali A. A. H., Kumar M. R. V. and Gokila A., Formulation and Evaluation of  Topical Drug Delivery System Containing Clobetasol Propionate Niosomes. Sci. Revs. Chem. Commun. 2011; 1(1): 7-17.
14.    Jain S., Patel N., Madan P., and Lin S. Quality by design approach for formulation, evaluation and statistical optimization of diclofenac-loaded ethosomes via transdermal route. Pharmaceutical Development and Technology. 2014; 1-18.
15.    Vaghasiya H., Kumar A. and Sawant K. Development of solid lipid nanoparticles based controlled release system for topical delivery of terbinafine hydrochloride. European Journal of Pharm aceutical Sciences. 2013; 49: 311-322.
16.    Kokane V.  and Naik S. Formulation and Evaluation of Topical Flurbiprofen Gel Using Different Gelling Agents. World Journal of Pharmacy and Pharmaceutical Sciences. 3(9): 654-663.
17.    Mishra N., Srivastava V., Kaushik A., Chauhan V., and Srivastava G. Formulation and in-vitro evaluation of Niosomes of Aceclofenac. Journal of Scientific and Innovative Research. 2014; 3(3): 337-341.
18.    Asthana G.S., Asthana A., Singh D., and Sharma P.K. Etodolac Containing Topical Niosomal Gel: Formulation Development and Evaluation. Journal of Drug DeliveryVolume. 2016, Article ID 9324567, 8 pages.
19.    Goyal G., Garg T., Malik B., Chauhan G., Rath G., and Goyal A. K. Development and characterization of niosomal gel for topical delivery of benzoyl peroxide. Drug Deliv. 2013. Early Online: 1–16.
20.    Goyal P, Kumar V, Sharma P. Carboxymethylation of Tamarind bit powder. Carb Polymers. 2007; 69: 251-55..
21.    Verma S., Bhardwaj A., Vij M., Bajpai P., Goutam N. and Kumar L. Oleic acid vesicles: a new approach for topical delivery of antifungal agent.  Artificial Cells, Nanomedicine, and Biotechnology.  2013; 1–7.
22.    Manconi M., Caddeo C., Sinico C., Valenti D., Mostallino M.C., BiggioG.andFadda A.M., Ex vivo skin delivery of diclofenac by transcutol containing liposomes and suggested mechanism of vesicle–skin interaction. European Journal of Pharmaceutics and Biopharmaceutics. 2011; 78: 27–35.
23.    Kumar YP, Kumar KV, Shekar RR, Ravi M and Kishore VS. Formulation and Evaluation of Econazole Niosomes. Sch. Acad. J. Pharm. 2013; 2(4): 315-318.
24.    Sara M. Abdel Samie, Amany O. Kamel, Omaima A. Sammour, Shady M. Ibrahim. Terbinafine hydrochloride nanovesicular gel: In vitro characterization,ex vivo permeation and clinical investigation. European Journal of Pharmaceutical Sciences. 2016; 88: 91–100.
25.    Wagh VD, Deshmukh OJ. ItraconazoleNiosomes Drug Delivery System and Its Antimycotic Activity against Candida albicans. ISRN Pharm. 2012: 653465.
26.    Vanmugilan S, Sathish M, Suresh R. Screening of Oxystelma esculentum R.BR extracts for Acetylcholinesterase Inhibitory Activity. Research Journal of Pharmacy and Technology. 2024; 17(2):467-0. doi: 10.52711/0974-360X.2024.00073
27.    Risna Agustina, Ronny Lesmana, Neily Zakiyah, Siti Nuriyatus Zahrah, Ajeng Diantini, Helmi. The Utilization of Biomarkers in Stress-Related Diseases. Research Journal of Pharmacy and Technology. 2024; 17(2): 471-8. doi: 10.52711/0974-360X.2024.00074
28.    Elsa Fitria Apriani, Shaum Shiyan, Dwi Hardestyariki, Viva Starlista, Anggitia Laras Sari. Optimization of Hydroxypropyl Methylcellulose (HPMC) and Carbopol 940 in Clindamycin HCl Ethosomal Gel as Anti-acne. Research Journal of Pharmacy and Technology. 2024; 17(2): 603-1. doi: 10.52711/0974-360X.2024.00094
29.    Apriani EF, Shiyan S, Hardestyariki D, Starlista V, Febriani M. Factorial Design for The Optimization of Clindamycin HCl-Loaded Ethosome with Various Concentration of Phospholipon 90G And Ethanol. Research Journal of Pharmacy and Technology. 2023; 16(4): 1561-8. https://doi.org/10.52711/0974-360X.2023.00255
30.    Mardiyanto M, Apriani, EF, Alfarizi MH. Formulation and In-Vitro Antibacterial Activity of Gel Containing Ethanolic Extract of Purple Sweet Potato Leaves (Ipomoea Batatas (L.)) Loaded Poly Lactic Co-Glycolic Acid Submicroparticles Against Staphylococcus aureus. Research Journal of Pharmacy and Technology. 2022; 15 (8): 3599-5. https://doi.org/ 10.52711/0974-360x.2022.00603
31.    Apriani EF, Shiyan S, Hardestyariki D, Starlista V, Febriani M. Factorial Design for The Optimization of Clindamycin HCl-Loaded Ethosome with Various Concentration of Phospholipon 90G And Ethanol. Research Journal of Pharmacy and Technology. 2023; 16(4): 1561-8. https://doi.org/10.52711/0974-360X.2023.00255


Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available