Author(s): K.V.R.N.S. Ramesh, Syed Arman Rabbani, Sirajunisa Talat, Mohammed Kamaruzzaman Bhuiyan, Tamer El Marsafawy, Quamrul Islam

Email(s): venkatramesh@rakmhsu.ac.ae

DOI: 10.52711/0974-360X.2024.00327   

Address: K.V.R.N.S. Ramesh1*, Syed Arman Rabbani1, Sirajunisa Talat1, Mohammed Kamaruzzaman Bhuiyan3, Tamer El Marsafawy2, Quamrul Islam1
1RAK College of Pharmacy, RAK Medical and Health Sciences University, Ras Al Khaimah, United Arab Emirates.
2Dean, IEQAA, RAK Medical and Health Sciences University, Ras Al Khaimah, United Arab Emirates.
3Julphar Gulf Pharmaceutical Industries.
*Corresponding Author

Published In:   Volume - 17,      Issue - 5,     Year - 2024


ABSTRACT:
The present study describes the influence of method of preparation and the role of ternary excipient on the solid dispersions prepared employing vitamin E tocopherol polyethylene glycol succinate 1000(Vit E TPGS). Different combinations of TPGS, Soluplus and Gelucire (50/13) are employed and freeze drying and solvent evaporation methods are comparatively evaluated for their efficiency in enhancing the dissolution of furosemide. Freeze drying and solvent evaporation methods were employed to prepare the solid dispersions of furosemide. The dispersions were characterized by dissolution study, X – ray diffraction, Differential Scanning Calorimeter, IR spectrophotometry and SEM study. Free flowing and higher dissolving dispersions could be prepared. The regression analysis of dissolution data suggested that increase in dissolution is an interplay of method employed and the ternary excipient used. The DSC, XRD and SEM studies confirmed that the drug is converted into an amorphous form while the IR spectral studies indicated no interaction between the drug and the carriers used in the investigation. The method of preparation and the ternary excipient influence the extent of improvement of dissolution of poorly soluble drugs.


Cite this article:
K.V.R.N.S. Ramesh, Syed Arman Rabbani, Sirajunisa Talat, Mohammed Kamaruzzaman Bhuiyan, Tamer El Marsafawy, Quamrul Islam. Ternary Solid Dispersions employing Vitamin E TPGS for enhancing dissolution - A Comparative Study of Surfactant combinations and preparation Methods. Research Journal of Pharmacy and Technology. 2024; 17(5):2063-0 doi: 10.52711/0974-360X.2024.00327

Cite(Electronic):
K.V.R.N.S. Ramesh, Syed Arman Rabbani, Sirajunisa Talat, Mohammed Kamaruzzaman Bhuiyan, Tamer El Marsafawy, Quamrul Islam. Ternary Solid Dispersions employing Vitamin E TPGS for enhancing dissolution - A Comparative Study of Surfactant combinations and preparation Methods. Research Journal of Pharmacy and Technology. 2024; 17(5):2063-0 doi: 10.52711/0974-360X.2024.00327   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2024-17-5-23


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