Author(s): Asegele Desta, Krishna Chaithanya K, Naveen Kumar A.D, Prasanthi Cheekurumelli, John Dogulas Palleti, Sudhish Rai. Zenebe Hagos

Email(s): zenebehagos.2003@gmail.com

DOI: 10.52711/0974-360X.2024.00368   

Address: Asegele Desta1, Krishna Chaithanya K1, Naveen Kumar A.D2, Prasanthi Cheekurumelli3, John Dogulas Palleti4, Sudhish Rai5. Zenebe Hagos1*
1Department of Chemistry, College of Natural and Computational Sciences, Aksum University, Axum, Ethiopia.
2Department of Medicine, Texila American University, Lilayi, Lusaka, Zambia.
3Department of Microbiology, St. Ann's College for Women, Malkapuram, Visakhapatnam, A.P. India.
4Research and Development, Centre for Computational and Biological Sciences (CCBS), 48-12-17, Srinagar, Near RTC Complex, Visakhapatnam - 530016, Andhra Pradesh, India.
5Department of Pharmacognosy, Jagrani Devi Pharmacy College, Baradwar, Shakti, Chhattisgarh, India.
*Corresponding Author

Published In:   Volume - 17,      Issue - 5,     Year - 2024


ABSTRACT:
Plant-derived medicines offer a safer alternative to synthetic options, providing significant therapeutic benefits and more economical treatment options. This study aimed to assess the physicochemical characteristics, chemical composition, and antioxidant properties of the essential oil extracted from Ocimum basilicum L. leaves harvested in Wukro. The oil was obtained using the hydrodistillation method, and its chemical composition was analyzed using GC-MS. various parameters including density, specific gravity, pH, boiling point, refractive index, acid value, saponification value, and ester value were considered. Antioxidant activities were evaluated using DPPH, ABTS, FRAP, NO inhibition, and OH free radical assays. The yield of oil was determined to be 0.14±0.016%, with GC-MS identifying 30 compounds. Major components included eugenol (32.69%), Octadecatrienoic acid (12.00%), and ethylisoallcholate (9.25%). Antioxidant activity increased with higher concentrations of the essential oil, suggesting synergistic effects among its components. These findings support the potential use of the essential oil as a natural source of antioxidants.


Cite this article:
Asegele Desta, Krishna Chaithanya K, Naveen Kumar A.D, Prasanthi Cheekurumelli, John Dogulas Palleti, Sudhish Rai. Zenebe Hagos. Physicochemical Characteristics, Chemical composition and In vitro Antioxidant activities of Essential oil from Ocimum basilicum L. Leaves. Research Journal of Pharmacy and Technology. 2024; 17(5):2352-8. doi: 10.52711/0974-360X.2024.00368

Cite(Electronic):
Asegele Desta, Krishna Chaithanya K, Naveen Kumar A.D, Prasanthi Cheekurumelli, John Dogulas Palleti, Sudhish Rai. Zenebe Hagos. Physicochemical Characteristics, Chemical composition and In vitro Antioxidant activities of Essential oil from Ocimum basilicum L. Leaves. Research Journal of Pharmacy and Technology. 2024; 17(5):2352-8. doi: 10.52711/0974-360X.2024.00368   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2024-17-5-64


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