Author(s):
Sadishkumar S, Vimal Kumar S, Mohith SN, Prathiba R, Abilash S, Mahesh AR
Email(s):
svimalkumar79@gmail.com , armahesh@hotmail.com
DOI:
10.52711/0974-360X.2024.00518 
Address:
Sadishkumar S1, Vimal Kumar S2*, Mohith SN1, Prathiba R1, Abilash S1, Mahesh AR3*
1Department of Pharmacology, Faculty of Pharmaceutical Sciences, PES University, Bengaluru,Karnataka, India.
2Department of Pharmacology, Al Shifa College of Pharmacy, Perinthalmanna, Malappuram, Kerala, India.
3Department of Pharmaceutical Chemistry, The Oxford College of Pharmacy, Bengaluru, Karnataka, India.
*Corresponding Author
Published In:
Volume - 17,
Issue - 7,
Year - 2024
ABSTRACT:
Sterols, Polyphenols, and flavonoids have a major role in erectile dysfunction. The molecular docking of phytochemical constituents of Fragaria ananassa fruit with human phosphodiesterase 5 (1UDT), human arginase II (4I06), human aromatase (5JKV), D2 dopamine receptor (6CM4) compared with sildenafil citrate. Using BIOVIA Discovery studio, ligand clusters were prepared, and PyRX software was used for molecular docking (Auto dock-Vina). Using PyMOL, the Protein-Ligand Complex was generated, and the 2D- interactions were obtained from BIOVIA Discovery studio. Most of the Phyto-constituents showed better binding affinity than sildenafil citrate. All 58 components have better GI absorption which ranges from 0% to 100%. The physicochemical, pharmacokinetics (ADME), and toxicity properties of bioactive molecules were evaluated to confirm their drug-likeness property. Most of the fifty-eight components are non-toxic and hence this study concludes that only certain sterols, polyphenols, and flavonoids from Fragaria ananassa fruit shows significant effects on erectile dysfunction.
Cite this article:
Sadishkumar S, Vimal Kumar S, Mohith SN, Prathiba R, Abilash S, Mahesh AR. In Silico Investigation of Chemical Components of Fragaria ananassa Species as Aphrodisiac Agents for Erectile Dysfunction. Research Journal of Pharmacy and Technology. 2024; 17(7):3315-9. doi: 10.52711/0974-360X.2024.00518
Cite(Electronic):
Sadishkumar S, Vimal Kumar S, Mohith SN, Prathiba R, Abilash S, Mahesh AR. In Silico Investigation of Chemical Components of Fragaria ananassa Species as Aphrodisiac Agents for Erectile Dysfunction. Research Journal of Pharmacy and Technology. 2024; 17(7):3315-9. doi: 10.52711/0974-360X.2024.00518 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2024-17-7-51
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