Author(s):
Zeenath Banu, Ayesha Qhursheed, A. Alekya, B. Shirisha, B.V. Mounika, B. Divya
Email(s):
banu.zeenath106@gmail.com
DOI:
10.52711/0974-360X.2024.00531 
Address:
Zeenath Banu1*, Ayesha Qhursheed2, A. Alekya2, B. Shirisha2, B.V. Mounika, B. Divya2
1Senior Assistant Professor, Department of Pharmacology, RBVRR Women's College of Pharmacy, Barkhatpura, Hyderabad - 500027, Telangana, India.
2Department of Pharmacology, RBVRR Women's College of Pharmacy, Barkhatpura, Hyderabad, Telangana – 500027.
*Corresponding Author
Published In:
Volume - 17,
Issue - 7,
Year - 2024
ABSTRACT:
This study was designed to investigate the phytoconstituents and antinociceptive effect of ethanolic extracts of Cosmos sulphureus (CS), Ruellia simplex (RS), and Hibiscus rosa sinensis (HR)flowers. The antinociceptive effect of flower extracts at two doses (100mg/kg and 200mg/kg) wasassessed using an acetic acid-induced writhing and tail immersion pain model.The flower extracts produced significant dose-dependent inhibition of nociceptive behaviour in the acetic acid-induced writhing test.When compared to the vehicle control group, the percentage of writhing inhibition reached around 70.7% and 69.07% in the groups of Hibiscus rosa sinensis and Cosmos sulphureus flower extracts that received the highest dose (200mg/kg). In the tail immersion method, the flower extracts showed a dose-dependent increase in the latency time and significantly (p<0.001) reduced pain as compared with the control group. Thus, flower extracts demonstrated peripheral and central antinociception via opioid receptor activation. The phytochemical analysis of flower extracts revealed that they contained alkaloids, glycosides, flavonoids, carbohydrates, steroids, tannins, and phenolic compounds. In conclusion,the flower extracts possess significant antinociceptive properties that are mediated through central and peripheral pathways.
Cite this article:
Zeenath Banu, Ayesha Qhursheed, A. Alekya, B. Shirisha, B.V. Mounika, B. Divya. Phytochemical and Pharmacological screening of Cosmos sulphureus, Ruellia simplex and Hibiscus rosa sinensis Flower Extracts for Antinociceptive activity. Research Journal of Pharmacy and Technology. 2024; 17(7):3399-4. doi: 10.52711/0974-360X.2024.00531
Cite(Electronic):
Zeenath Banu, Ayesha Qhursheed, A. Alekya, B. Shirisha, B.V. Mounika, B. Divya. Phytochemical and Pharmacological screening of Cosmos sulphureus, Ruellia simplex and Hibiscus rosa sinensis Flower Extracts for Antinociceptive activity. Research Journal of Pharmacy and Technology. 2024; 17(7):3399-4. doi: 10.52711/0974-360X.2024.00531 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2024-17-7-64
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