Author(s): Riga Riga, Mauline Adia Silvani, Wandi Oktria, Suryelita Suryelita, Sri Benti Etika, Bali Yana Fitri, Sonni Maurit Benu, Mariam Ulfah, Fitri Yuranda

Email(s): rigakimia@fmipa.unp.ac.id

DOI: 10.52711/0974-360X.2024.00571   

Address: Riga Riga1*, Mauline Adia Silvani1, Wandi Oktria1, Suryelita Suryelita1, Sri Benti Etika1, Bali Yana Fitri1, Sonni Maurit Benu2 , Mariam Ulfah3, Fitri Yuranda1,4
1Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Jl. Prof. Dr. Hamka, Padang, Indonesia.
2Department of Chemistry, Faculty of Mathematics and Natural Sciences, Institute Teknologi Bandung, Jl. Ganesha 10, Bandung, Indonesia.
3Department of Pharmacy, STIKES Muhammadiyah Cirebon, Cirebon, Indonesia.
4Department of Environmental Engineering, Faculty of Engineering, Universitas Andalas, Padang, Indonesia.
*Corresponding Author

Published In:   Volume - 17,      Issue - 8,     Year - 2024


ABSTRACT:
Fungal Phyllosticta capitalensis is reported to produce secondary metabolites with important bioactivities, i.e., antibacterial and antioxidant. This is the first time that the fungal P. capitalensis has been isolated from Andrographis paniculata twigs. Secondary metabolites isolation from the extract of the fungus P. capitalensis was performed using several techniques of chromatography, i.e., vacuum liquid chromatography and column chromatography, to obtain two pure compounds (1 and 2). Both compounds were determined for their structures using analyzing data of spectroscopy of NMR and FT-IR. Based on the analysis, compounds 1 and 2 were ergosterol and ergosterol peroxide, respectively. Both steroids were evaluated for their bioactivities following agar dilution method for antibacterial activity. Compound 2 was more active against three bacterial strains than compound 1. Based on the structure-activity relationship, presence of peroxide in C-5 and C-8 increases the bioactivity of ergosterol derivatives. Interestingly, herein, ergosterol peroxide (2) is firstly reported f from fungal P. capitalensis.


Cite this article:
Riga Riga, Mauline Adia Silvani, Wandi Oktria, Suryelita Suryelita, Sri Benti Etika, Bali Yana Fitri, Sonni Maurit Benu, Mariam Ulfah, Fitri Yuranda. Isolation, Structure Elucidation and Antibacterial activity of Secondary Metabolites from Fungal Phyllosticta capitalensis. Research Journal of Pharmacy and Technology. 2024; 17(8):3663-8. doi: 10.52711/0974-360X.2024.00571

Cite(Electronic):
Riga Riga, Mauline Adia Silvani, Wandi Oktria, Suryelita Suryelita, Sri Benti Etika, Bali Yana Fitri, Sonni Maurit Benu, Mariam Ulfah, Fitri Yuranda. Isolation, Structure Elucidation and Antibacterial activity of Secondary Metabolites from Fungal Phyllosticta capitalensis. Research Journal of Pharmacy and Technology. 2024; 17(8):3663-8. doi: 10.52711/0974-360X.2024.00571   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2024-17-8-19


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