Author(s): Naveen Maled, V M Chandrashekar, Mallappa Shalavadi, G S Hiremath, Lingaraj Anawal, Shubham Teli, Sushma Kagawade, Sunilkumar Meti, Bhushan Khombare, Veeresh Sadashivanavar

Email(s): naveenmaled1007@gmail.com , chandupharm75@gmail.com , mallu.sha007@gmail.com , gshiremath@gmail.com , lingarajanawal@gmail.com , shubhamteli02@gmail.com , sushmakagawade2727@gmail.com , sunilmeti87@gmail.com , bhushankhombare@gmail.com , veereshsadashivanavar@gmail.com

DOI: 10.52711/0974-360X.2024.00599   

Address: Naveen Maled1*, V M Chandrashekar1, Mallappa Shalavadi1, G S Hiremath1, Lingaraj Anawal1, Shubham Teli1, Sushma Kagawade1, Sunilkumar Meti1, Bhushan Khombare1, Veeresh Sadashivanavar2
1Department of Pharmacology BVVS Hanagal Shri Kumareshwar College of Pharmacy, Bagalkote – 587101.
2Department of Pharmaceutical Chemistry, BVVS Hanagal Shri Kumareshwar College of Pharmacy, Bagalkote – 587101.
*Corresponding Author

Published In:   Volume - 17,      Issue - 8,     Year - 2024


ABSTRACT:
Purpose: To examine the effect of Cansjera rheedii in gentamicin induced kidney damage in rats. Material and Method: In this current study, rats in group 1 were used as the normal group and were given physiological saline. Rats of group 2 were injected with gentamicin [100mg/kg] via intraperitoneal injection. Group 3 was given gentamicin (100mg/kg, IP) together with oral selenium [2mg/kg]. Hydroalcoholic extract (HECR) of Cansjera rheedii leaves was administered orally to groups 4 and 5 in low dose of 200mg/kg and high dose of 400 mg/kg, respectively. Above treatments were given to rats over eight days. Blood serum and urine were collected on the 8th day to evaluate blood and urine biochemical parameters. Antioxidant parameters were evaluated using renal homogenates. Kidney sections were used for histopathological examination. Result: The renoprotective effect of HECR plant extract was evident at both low and high dose [200mg/kg and 400mg/kg]. This action maintains structural and functional integrity by preventing damage caused by gentamicin. This protection is attributed to the antioxidant properties of the extract.


Cite this article:
Naveen Maled, V M Chandrashekar, Mallappa Shalavadi, G S Hiremath, Lingaraj Anawal, Shubham Teli, Sushma Kagawade, Sunilkumar Meti, Bhushan Khombare, Veeresh Sadashivanavar. Nephroprotective effect of Cansjera rheedii on Gentamicin induced Renal toxicity in Wistar albino ratsResearch Journal of Pharmacy and Technology. 2024; 17(8):3863-8. doi: 10.52711/0974-360X.2024.00599

Cite(Electronic):
Naveen Maled, V M Chandrashekar, Mallappa Shalavadi, G S Hiremath, Lingaraj Anawal, Shubham Teli, Sushma Kagawade, Sunilkumar Meti, Bhushan Khombare, Veeresh Sadashivanavar. Nephroprotective effect of Cansjera rheedii on Gentamicin induced Renal toxicity in Wistar albino ratsResearch Journal of Pharmacy and Technology. 2024; 17(8):3863-8. doi: 10.52711/0974-360X.2024.00599   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2024-17-8-47


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