ABSTRACT:
The goal of the current study is to create and assess ACF tablets with ternary solid dispersed product. ACF is poor solubility and a member of BCS class II. Water-soluble polymers and a biosurfactant were included in the formulation of the ternary system to improve bioavailability and dissolution rate. By employing the solvent evaporation method to prepare hydroxyl propyl methyl cellulose (HPMC) K-100 and polyethylene glycol (PEG) 6000 as biosurfactants and polymers, apiece, binary and ternary solid dispersions were prepared and assessed for drug content uniformity and in-vitro dissolution studies. By using a direct compression approach, ternary solid dispersed product was combined with additional excipients to create ACF tablets. Pre- and post-compression parameters were assessed for prepared formulations. The optimized tablet formulations TSD3 and TSD6 demonstrated an in-vitro dissolving profile of 96.85% and 99.85%, respectively, at a pH buffer of 6.8. The prepared pills' pre- and post-compression values fell between the designated permissible ranges. An increase in the solubility rate consistent with pure medication was seen in a dissolution investigation of the improved formulation TSD6. At room temperature, the improved formulation's short-term stability remained constant. For improved dissolution rate, dose reduction, and bioavailability in the formulation of ACF tablets, the incorporation of surface-active biomolecules to the ternary solid dispersion system showed to be a suitable excipient.