Author(s):
Rakan Abdullah Alsaqer, Shobhana N, N Raghavendra Naveen, Prasiddhi Naik, Prakash Goudanavar, Nagaraja Sreeharsha, Amal Rasul Al Turaifi, Girish Meravanige, Afzal Haq Asif
Email(s):
pgoudanavar01@gmail.com , gmeravanige@kfu.edu.sa
DOI:
10.52711/0974-360X.2025.00680 
Address:
Rakan Abdullah Alsaqer1, Shobhana N2, N Raghavendra Naveen2, Prasiddhi Naik2, Prakash Goudanavar2, Nagaraja Sreeharsha1, Amal Rasul Al Turaifi1, Girish Meravanige3, Afzal Haq Asif4
1Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University Al-Ahsa, 31982, Kingdom of Saudi Arabia
2Department of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G.Nagar, Karnataka, 571448
3Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa 31982, Saudi Arabia
4Department of Pharmacy Practice, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia
*Corresponding Author
Published In:
Volume - 18,
Issue - 10,
Year - 2025
ABSTRACT:
A novel method for administering paclitaxel (PTX) to treat breast cancer was developed using biocompatible, nano-sized magnetic nanoparticles (MNPs) coated with oleic acid, ebedded into transdermal patches. These nanoparticles were synthesized through a modified co-precipitation method, using chitosan polymer. The resulting transdermal patches contained PTX-coupled chitosan-coated oleic acid-based MNPs (PTX-CS-OA-MNPs) and were formulated using HPMC, EC, and PEG400. The study focused on evaluating the physical and chemical properties of the patches, as well as their impact on breast cancer cell lines and drug diffusion in vitro. The PTX-CS-OA-MNP patches exhibited uniform thickness, flexibility, surface pH stability, and efficient nanoparticle dispersion. Notably, these patches demonstrated enhanced drug permeability, achieving fivefold greater penetration compared to free PTX. Additionally, they showed improved cytotoxicity against triple-negative breast cancer cells. MTT assays, cellular uptake studies, and in vivo pharmacodynamic evaluations confirmed the efficacy and safety of the PTX-CS-OA-MNP patches in anticancer biomedical applications. The nanoformulations magnetic properties, drug loading efficiency, release profile, and particle size distribution were promising for the non-invasive delivery of PTX.
Cite this article:
Rakan Abdullah Alsaqer, Shobhana N, N Raghavendra Naveen, Prasiddhi Naik, Prakash Goudanavar, Nagaraja Sreeharsha, Amal Rasul Al Turaifi, Girish Meravanige, Afzal Haq Asif. Developing a Localized Delivery of Polymer-Based Targeted Nanoparticles Through Paclitaxel-Loaded Transdermal Patches for Breast Cancer Therapy: A Proof-of-Concept. Research Journal of Pharmacy and Technology. 2025;18(10):4727-5. doi: 10.52711/0974-360X.2025.00680
Cite(Electronic):
Rakan Abdullah Alsaqer, Shobhana N, N Raghavendra Naveen, Prasiddhi Naik, Prakash Goudanavar, Nagaraja Sreeharsha, Amal Rasul Al Turaifi, Girish Meravanige, Afzal Haq Asif. Developing a Localized Delivery of Polymer-Based Targeted Nanoparticles Through Paclitaxel-Loaded Transdermal Patches for Breast Cancer Therapy: A Proof-of-Concept. Research Journal of Pharmacy and Technology. 2025;18(10):4727-5. doi: 10.52711/0974-360X.2025.00680 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2025-18-10-19
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