Author(s):
Rahul Vasant Jadhav, Praveen Sharma
Email(s):
rahuljadhav671@gmail.com
DOI:
10.52711/0974-360X.2025.00709 
Address:
Rahul Vasant Jadhav*, Praveen Sharma
Faculty of Pharmacy, Oriental University, Jakhya, Indore, 453555, Madhya Pradesh, India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 10,
Year - 2025
ABSTRACT:
Background and Aim: The Amaranthaceae family have gained attention for their potential antiulcer properties. Peptic ulcers, a prevalent gastrointestinal disorder, necessitate the exploration of alternative therapies, and Amaranthaceae species may offer promising leads in this regard. Therefore, we have selected Achyranthes aspera from the Amaranthaceae family for the evaluation of antioxidant and antiulcer properties. Methodology: Successive Soxhlet extraction technique was used to extract the plant materials with Petroleum ether, chloroform, methanol, and water. The antioxidant activity of the plant extracts and the standard drugs were based on consideration of the radical scavenging influence of the stable "1,1-diphenyl-2-picrylhydrazyl" (DPPH) free radical action and hydrogen peroxide process. Non-steroidal anti-inflammatory induced ulcer and pyloric ligation, method were used to assess antiulcer effect of methanolic extract of Achyranthes aspera (MEAA). Result: The phytochemical examination of methanolic extracts reveals the presence of triterpenoids, flavonoids, alkaloids, tannins, glycosides, and proteins. The antioxidant study results revealed that among all the four extracts, the MEAA possesses significant antioxidant potential. Compared with control, there were a significant (p<0.05) decrease in gastric volume, total and free acidity in the extract-treated classes and standard class. The MEAA revealed significant (p<0.05) percent inhibition, i.e. 59.42 and 69.59 percent with 500 mg/ml PL and NSAID, respectively. Conclusion: The present research findings demonstrated that the methanolic extract of Achyranthes aspera possesses significant antioxidant and antiulcer activity.
Cite this article:
Rahul Vasant Jadhav, Praveen Sharma. In-vivo Anti-Ulcer Screening of Methanolic Extract of Achyranthes aspera. Research Journal of Pharmacy and Technology. 2025;18(10):4915-0. doi: 10.52711/0974-360X.2025.00709
Cite(Electronic):
Rahul Vasant Jadhav, Praveen Sharma. In-vivo Anti-Ulcer Screening of Methanolic Extract of Achyranthes aspera. Research Journal of Pharmacy and Technology. 2025;18(10):4915-0. doi: 10.52711/0974-360X.2025.00709 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2025-18-10-48
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