Author(s):
Chandrashekar C. Patil, Geeta Singri, Santosh Karajgi, Syed Samiulla Hundekar, Kavita R.N., Abhishek Morabale
Email(s):
drccpatil@gmail.com
DOI:
10.52711/0974-360X.2025.00748 
Address:
Chandrashekar C. Patil1*, Geeta Singri1, Santosh Karajgi1, Syed Samiulla Hundekar2, Kavita R.N.1, Abhishek Morabale1
1Department of Pharmaceutics, B.L.D.E.A’s SSM College of Pharmacy, Vijayapur - 586101, Karnataka.
2Sharanabasaveshwar College of Pharmacy, Vijayapur - 586102, Karnataka.
*Corresponding Author
Published In:
Volume - 18,
Issue - 11,
Year - 2025
ABSTRACT:
Mucoadhesive controlled-release tablets enhance drug efficacy by regulating drug concentrations within the therapeutic window, facilitating targeted delivery to specific sites, achieved through the formulation of oral tablets incorporating captopril and mucoadhesive polymers such as Tamarind Seed Polymer, Blackgram, Sodium alginate, Chitosan, Hydroxy propyl methylcellulose and Sodium CMC. The polymer extraction process involved isolating mucilage using conventional methods. Various concentrations of the polymers were utilized to achieve sustained drug release spanning duration of 12hours. The tablets underwent assessment based on multiple parameters including drug content, thickness, hardness, pH of the surface, swelling capacity, mucoadhesive strength, washout time, and drug release. The dissolution profiles underwent various kinetic analyses to scrutinize the drug release pattern, revealing a diffusion mechanism for drug release. Notably, formulation F7, comprising TSP and HPMC, demonstrated the highest bioadhesive strength of 50gm. additionally; it’s in vitro drug release reached 96.70% after 12hours, characterized by a non-Fickian diffusion mechanism. Following storage at 45ºC/75% RH for three months, there were no notable changes detected in the drug content, adhesive properties, clearance rate, or dissolution behavior in vitro
Cite this article:
Chandrashekar C. Patil, Geeta Singri, Santosh Karajgi, Syed Samiulla Hundekar, Kavita R.N., Abhishek Morabale. Development and Evaluation of Gastroretentive Mucoadhesive Captopril Tablets. Research Journal Pharmacy and Technology. 2025;18(11):5183-0. doi: 10.52711/0974-360X.2025.00748
Cite(Electronic):
Chandrashekar C. Patil, Geeta Singri, Santosh Karajgi, Syed Samiulla Hundekar, Kavita R.N., Abhishek Morabale. Development and Evaluation of Gastroretentive Mucoadhesive Captopril Tablets. Research Journal Pharmacy and Technology. 2025;18(11):5183-0. doi: 10.52711/0974-360X.2025.00748 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2025-18-11-10
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