Author(s):
Deni Setiawan, Samsul Hadi, Nurul Mardiati, Nur Mahdi, Amalia Khairunnisa, Aisya Aqifah, Hasyrul Hamzah, Siswadi
Email(s):
deni.setiawan@ulm.ac.id
DOI:
10.52711/0974-360X.2025.00752 
Address:
Deni Setiawan1*, Samsul Hadi1, Nurul Mardiati1, Nur Mahdi1, Amalia Khairunnisa1, Aisya Aqifah1, Hasyrul Hamzah2, Siswadi3
1Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Lambung Mangkurat Banjarbaru, South Kalimantan, Indonesia.
2Department of Pharmacy, Faculty of Pharmacy, Universitas Muhammadiyah Kalimantan Timur, Samarinda, Indonesia.
3Research Organization for Health, National Research and Innovation Agency, Republic of Indonesia. Bogor, Indonesia.
*Corresponding Author
Published In:
Volume - 18,
Issue - 11,
Year - 2025
ABSTRACT:
Diabetic ulcer infections present a substantial obstacle to wound management due to the prevalence of persistent bacterial biofilms that are impervious to conventional antibiotic therapies. Nanomaterials have emerged as a revolutionary platform for addressing the challenges of antibiotic resistance and biofilm-associated infections. Researchers have the potential to employ Kratom in the development of antibiofilm medicines specifically designed to combat diabetic ulcer infections. This is due to its capacity to impede bacterial quorum sensing and disrupt the process of biofilm development. Objective of this study is to determine the antibiofilm properties of the nanogel derived from kratom extract in diabetic ulcer infections. The study was carried out on a 96-well flat-bottom polystyrene microtiter plate using various doses of test chemicals (1%, 0.5%, 0.25%, 0.125% w/v) to identify their effects on S. aureus. The concentration of extract in nanogel used was 10, 20, and 30% to test antibiofilm in the mid-phase, maturation, and eradication phases. In the mid-phase biofilm, Kratom-derived nanogel extract (KDNE) at a concentration of 30% w/v exhibited significant antibiofilm efficacy against Staphylococcus aureus (SA), with an inhibition percentage of 79.21% ± 0.08; maturation phase of 74.12% ± 0,101; and eradication of 67.25% ± 0.046. KDNE compounds have shown efficacy against Staphylococcus aureus, suggesting their potential as natural antibacterial and antibiofilm agents.
Cite this article:
Deni Setiawan, Samsul Hadi, Nurul Mardiati, Nur Mahdi, Amalia Khairunnisa, Aisya Aqifah, Hasyrul Hamzah, Siswadi. Nanogel Formulations of Kratom (Mitragyna speciosa) Extract: A Promising Antibiofilm agent for Diabetic Ulcer Infections. Research Journal Pharmacy and Technology. 2025;18(11):5216-2. doi: 10.52711/0974-360X.2025.00752
Cite(Electronic):
Deni Setiawan, Samsul Hadi, Nurul Mardiati, Nur Mahdi, Amalia Khairunnisa, Aisya Aqifah, Hasyrul Hamzah, Siswadi. Nanogel Formulations of Kratom (Mitragyna speciosa) Extract: A Promising Antibiofilm agent for Diabetic Ulcer Infections. Research Journal Pharmacy and Technology. 2025;18(11):5216-2. doi: 10.52711/0974-360X.2025.00752 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2025-18-11-14
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