Author(s):
Shefali P. Thakkar, Nikita C. Naterwalla, Kirti S. Laddha
Email(s):
pajwanis@gmail.com
DOI:
10.52711/0974-360X.2025.00760 
Address:
Shefali P. Thakkar1*, Nikita C. Naterwalla1, Kirti S. Laddha2
1Department of Research and Product Development, Arelang Naturals Pvt. Ltd., Lower Parel, Mumbai - 400013, Maharashtra, India.
2Department of Medicinal and Natural Products, Institute of Chemical Technology, Matunga, Mumbai - 400019, Maharashtra, India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 11,
Year - 2025
ABSTRACT:
The study aimed to evaluate the efficacy of "Rekindle for Women," a plant-based candyceutical, in alleviating the symptoms of hormonal imbalance in females over a 90-day period. Rekindle for Women includes a carefully selected blend of ingredients, such as flaxseed, soya isoflavones, black cohosh, saffron, ginseng, and shatavari, each known for their roles in promoting hormonal health. A total of 121 women, aged 20-60 years, participated in this focused group study, rating their experiences on a scale of 1-10 across several parameters: menstrual cycle regulation, abdominal pain/cramps, mood swings, bloating, libido, hot/cold flashes, and vaginal dryness. Statistical analysis revealed significant improvements in key symptoms, particularly in menstrual cycle regulation (average score: 7.49), reduction of abdominal pain/cramps (7.55), and reduction of mood swings (7.61). The greatest benefits were observed among women with PCOD and perimenopausal symptoms. The findings suggest that "Rekindle for Women," composed of flaxseed, soya isoflavones, black cohosh, saffron, ginseng, and shatavari, is effective in addressing hormonal imbalances. These results support its potential as a natural intervention for women's hormonal health, warranting further research and clinical trials to confirm its efficacy.
Cite this article:
Shefali P. Thakkar, Nikita C. Naterwalla, Kirti S. Laddha. Efficacy of "Rekindle for Women" Candyceutical in Hormonal Balance: A 90-Day Focused Group Study. Research Journal Pharmacy and Technology. 2025;18(11):5275-0. doi: 10.52711/0974-360X.2025.00760
Cite(Electronic):
Shefali P. Thakkar, Nikita C. Naterwalla, Kirti S. Laddha. Efficacy of "Rekindle for Women" Candyceutical in Hormonal Balance: A 90-Day Focused Group Study. Research Journal Pharmacy and Technology. 2025;18(11):5275-0. doi: 10.52711/0974-360X.2025.00760 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2025-18-11-22
REFERENCES:
1. Segarra I, Menárguez M, Roqué MV. Women's health, hormonal balance and personal autonomy. Front Med (Lausanne). 2023; 10: 1167504. doi:10.3389/fmed.2023.1167504.
2. R. Renuka. A Study to Assess the Impact of Physical Activity on Menopausal Symptoms among Women in a Selected Area, Coimbatore. Asian J. Nur. Edu. and Research. 2015; 5(1): 78-81.
3. Sanasam Birjeni Devi, C. Susila. Diagnosis, causal factors and associated diseases of PCOS: A Mini-review. Asian Journal of Nursing Education and Research. 2022; 12(1): 138-3.
4. Omkar A. Devade, Rohan D. Londhe, Nisarga V. Sokate, Utkarsha R. Randave, Pallavi A. Ranpise. A Review on: Polycystic Ovarian Disorder. Asian Journal of Research in Pharmaceutical Sciences. 2022; 12(3): 219-6.
5. Harper-Harrison G, Carlson K, Shanahan MM. Hormone Replacement Therapy. StatPearls [Internet]. 2024; [Updated 2024 Aug 11].
6. Arjun Singh. An Overview on Phytoestrogen based antihypertensive agent for their potential Pharmacological Mechanism. Research Journal of Pharmaceutical Dosage Forms and Technology. 2023; 15(3): 211-4.
7. Ahsas Goyal, Jeetendra Kumar Gupta, Debapriya Garabadu. Phytoestrogens are emerging medicine in Prevention and Management of Cognitive deficits in Postmenopausal Women. Research J. Pharm. and Tech. 2021; 14(1): 513-515.
8. Abha Kispotta, Lija Prince, Saumya Thomas. An Experimental study to assess the effectiveness of Flax Seed Supplement for reducing PCOD symptoms among female of reproductive age group in Namkum, Ranchi, Jharkhand. International Journal of Advances in Nursing Management. 2022; 10(4): 379-4.
9. Canivenc-Lavier MC, Bennetau-Pelissero C. Phytoestrogens and health effects. Nutrients. 2023; 15(2): 317. doi:10.3390/nu15020317.
10. Al-Madhagy S, Ashmawy NS, Mamdouh A, Eldahshan OA, Farag MA. A comprehensive review of the health benefits of flaxseed oil in relation to its chemical composition and comparison with other omega-3-rich oils. Eur J Med Res. 2023; 28(1): 240. doi:10.1186/s40001-023-00705-y.
11. Nowak DA, Snyder DC, Brown AJ, Demark-Wahnefried W. The effect of flaxseed supplementation on hormonal levels associated with polycystic ovarian syndrome: A case study. Curr Top Nutraceutical Res. 2007; 5(4): 177-81.
12. Brouns F. Soya isoflavones: A new and promising ingredient for the health foods sector. Food Res Int. 2002; 35(2–3): 187-93. doi:10.1016/S0963-9969(01)00132-1.
13. Křížová L, Dadáková K, Kašparovská J, Kašparovský T. Isoflavones. Molecules. 2019; 24(6): 1076. doi:10.3390/ molecules24061076.
14. Pejčić T, Zeković M, Bumbaširević U, et al. The role of isoflavones in the prevention of breast cancer and prostate cancer. Antioxidants (Basel). 2023; 12(2): 368. doi:10.3390/ antiox12020368.
15. Chen LR, Ko NY, Chen KH. Isoflavone supplements for menopausal women: A systematic review. Nutrients. 2019; 11(11): 2649. doi:10.3390/nu11112649.
16. Chen LR, Chen KH. Utilization of isoflavones in soybeans for women with menopausal syndrome: An overview. Int J Mol Sci. 2021; 22(6): 3212. doi:10.3390/ijms22063212.
17. Gómez-Zorita S, González-Arceo M, Fernández-Quintela A, et al. Scientific evidence supporting the beneficial effects of isoflavones on human health. Nutrients. 2020; 12(12): 3853. doi:10.3390/ nu12123853.
18. Borrelli F, Ernst E. Black cohosh (Cimicifuga racemosa) for menopausal symptoms: A systematic review of its efficacy. Pharmacol Res. 2008; 58(1): 8-14. doi:10.1016/ j.phrs.2008.03.002.
19. Mohapatra S, Iqubal A, Ansari MJ, et al. Benefits of black cohosh (Cimicifuga racemosa) for women’s health: An up-close and in-depth review. Pharmaceuticals. 2022; 15(3): 278. doi:10.3390/ ph15030278.
20. Powell SL, Gödecke T, Nikolic D, et al. In vitro serotonergic activity of black cohosh and identification of N(omega)-methylserotonin as a potential active constituent. J Agric Food Chem. 2008; 56(24): 11718-26. doi:10.1021/jf801724c.
21. Hill DA, Crider M, Hill SR. Hormone therapy and other treatments for symptoms of menopause. Am Fam Physician. 2016; 94(11): 884-9.
22. Sarri G, Pedder H, Dias S, et al. Vasomotor symptoms resulting from natural menopause: A systematic review and network meta-analysis of treatment effects from the National Institute for Health and Care Excellence guideline on menopause. BJOG. 2017; 124(10): 1514-23. doi:10.1111/1471-0528.14557.
23. Anaeigoudari F, Anaeigoudari A, Kheirkhah-Vakilabad A. A review of therapeutic impacts of saffron (Crocus sativus L.) and its constituents. Physiol Rep. 2023; 11(15). doi:10.14814/ phy2.15366.
24. El Midaoui A, Ghzaiel I, Vervandier-Fasseur D, et al. Saffron (Crocus sativus L.): A source of nutrients for health and for the treatment of neuropsychiatric and age-related diseases. Nutrients. 2022; 14(3): 597. doi:10.3390/nu14030597.
25. Kishu Tripathi. Herbs for Depression: A Review . Research J. Science and Tech. 2009; 1(2): 55-62.
26. Jackson PA, Forster J, Khan J, et al. Effects of saffron extract supplementation on mood, well-being, and response to a psychosocial stressor in healthy adults: A randomized, double-blind, parallel group clinical trial. Front Nutr. 2021; 7: 606124. doi:10.3389/fnut.2020.606124.
27. Lopresti AL, Smith SJ. The effects of a saffron extract (affron®) on menopausal symptoms in women during perimenopause: A randomized double-blind placebo-controlled study. J Menopausal Med. 2021; 27(2): 66-78. doi:10.6112/jmm.2021.27.2.66.
28. Nanda S, Madan K. The role of safranal and saffron stigma extracts in oxidative stress, diseases, and photoaging: A systematic review. Heliyon. 2021; 7(2). doi:10.1016/ j.heliyon.2021.e06243.
29. Liao LY, He YF, Li L, et al. A preliminary review of studies on adaptogens: Comparison of their bioactivity in TCM with that of ginseng-like herbs used worldwide. Chin Med. 2018; 13: 57. doi:10.1186/s13020-018-0185-2.
30. Hou W, Wang Y, Zheng P, Cui R. Effects of ginseng on neurological disorders. Front Cell Neurosci. 2020; 14: 55. doi:10.3389/fncel.2020.00055.
31. Lee S, Rhee DK. Effects of ginseng on stress-related depression, anxiety, and the hypothalamic-pituitary-adrenal axis. J Ginseng Res. 2017; 41(4): 589-94. doi:10.1016/j.jgr.2016.09.008.
32. Park J, Song H, Kim SK, et al. Effects of ginseng on two main sex steroid hormone receptors: estrogen and androgen receptors. J Ginseng Res. 2017; 41(2): 215-21. doi:10.1016/j.jgr.2016.06.007.
33. Lee HW, Ang L, Lee MS. Using ginseng for menopausal women's health care: A systematic review of randomized placebo-controlled trials. Complement Ther Clin Pract. 2022; 48: 101615. doi:10.1016/j.ctcp.2022.101615.
34. Alok S, Jain SK, Verma A, et al. Plant profile, phytochemistry, and pharmacology of Asparagus racemosus (Shatavari): A review. Asian Pac J Trop Dis. 2013; 3(3): 242-51. doi:10.1016/S2222-1808(13)60068-4.
35. Sri Devi Masilamani, Rajeswari Hari, Gomathi Kannaiyram, Priya Chokkalingam. Asparagus racemosus – A potential PCOD healer through the management of hyperglycaemia and hyperandrogenism, An In vitro and in silico approach. Research Journal of Pharmacy and Technology 2023; 16(5): 2096-2.
36. Sharma K, Bhatnagar M. Asparagus racemosus (Shatavari): A versatile female tonic. Int J Pharm Biol Arch. 2011; 2(3): 855-63.
37. Pandey AK, Gupta A, Tiwari M, et al. Impact of stress on female reproductive health disorders: Possible beneficial effects of shatavari (Asparagus racemosus). Biomed Pharmacother. 2018; 103: 46-49. doi:10.1016/j.biopha.2018.04.049.
38. Gudise VS, Dasari MP, Kuricheti SS. Efficacy and safety of shatavari root extract for the management of menopausal symptoms: A double-blind multicenter randomized controlled trial. Cureus. 2024; 16(4). doi:10.7759/cureus.42564.