Author(s):
Sachin A Kumbar, Abhirami PV, Anusha S, Ranjitha Acharya, Arvinda Pai, Pankaj Kumar
Email(s):
pankajpgr@nitte.edu.in
DOI:
10.52711/0974-360X.2025.00783 
Address:
Sachin A Kumbar1, Abhirami PV1, Anusha S1, Ranjitha Acharya1, Arvinda Pai2, Pankaj Kumar1*
1Nitte (Deemed to be University), NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Department of Pharmaceutical Chemistry, Mangalore, India.
2Department of Pharmaceutical Chemistry, MCOPS, MAHE, Manipal, Karnataka, India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 11,
Year - 2025
ABSTRACT:
Diabetes mellitus is a growing concern, and coumarins with thiazole groups have shown promise in managing the disease with fewer side effects. Thiazolyl coumarin derivatives were synthesized and characterized via IR, Mass, and ¹H NMR spectroscopy. In-silico analysis against a-glucosidase and a-amylase revealed that compounds C1, C2, and C3 had the highest docking scores compared to acarbose. Antioxidant and antidiabetic activities were assessed, with C4 showing the strongest a-amylase inhibition and C7 the highest a-glucosidase inhibition. Compounds C1 and C3 showed significant activity in both assays, making them strong candidates for further hypoglycaemic development.
Cite this article:
Sachin A Kumbar, Abhirami PV, Anusha S, Ranjitha Acharya, Arvinda Pai, Pankaj Kumar. Multicomponent Synthesis, In-silico ADMET Properties, Docking Studies, Antidiabetic and Antioxidant Activities of Novel Thiazolyl fused Chromen-2-one derivatives. Research Journal Pharmacy and Technology. 2025;18(11):5431-7. doi: 10.52711/0974-360X.2025.00783
Cite(Electronic):
Sachin A Kumbar, Abhirami PV, Anusha S, Ranjitha Acharya, Arvinda Pai, Pankaj Kumar. Multicomponent Synthesis, In-silico ADMET Properties, Docking Studies, Antidiabetic and Antioxidant Activities of Novel Thiazolyl fused Chromen-2-one derivatives. Research Journal Pharmacy and Technology. 2025;18(11):5431-7. doi: 10.52711/0974-360X.2025.00783 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2025-18-11-45
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