Author(s):
Maria Magdalena Riyaniarti Estri Wuryandari, Ninis Yuliati, Vivien Dwi Purnamasari
Email(s):
mm.riyaniarti@iik.ac.id
DOI:
10.52711/0974-360X.2025.00801 
Address:
Maria Magdalena Riyaniarti Estri Wuryandari1, Ninis Yuliati1, Vivien Dwi Purnamasari2
1Departement of Pharmacy, Faculty of Pharmacy, Institut Ilmu Kesehatan Bhakti Wiyata, Kediri, 64114 East Java, Indonesia.
2Bachelor of Publich Health, Faculty of Health Management Technology, Institut Ilmu Kesehatan Bhakti Wiyata, Kediri, 64114 East Java, Indonesia.
*Corresponding Author
Published In:
Volume - 18,
Issue - 11,
Year - 2025
ABSTRACT:
Hepatotoxicity, or liver damage caused by infection or chronic inflammation, is often a challenge in managing typhoid fever. This infection triggers an immune response involving various immune cells, including NK cells and macrophages. NK cells play a crucial role in identifying and destroying infected cells, while macrophages are involved in pathogen phagocytosis and cytokine production, which can exacerbate inflammation. Objective: The present study aimed to evaluate Moringa oleifera extract effects on S. typhi infection in mice. Materials and method: Female Balb/C mice were randomly divided into eight groups. The treatment groups were orally administered with extract Moringa oleifera at doses 14, 42, and 84 mg/kg BW during the 28 days experimental period. Then S. typhi was introduced to mice through intraperitoneal injection except in the healthy groups. The extract Moringa oleifera administration was continued for the next seven days. Cells that expressed CD11b+TNF-a+, NK+IFN-?+ were assessed by flow cytometry and analysis liver with Hematoxylin and Eosin (HE). Result Our result suggested that Moringa oleifera extract significantly increased (p < 0.05) the expression of CD11b +TNF-a+, NK+IFN-?+ subsets. Conclusion: The Moringa leaf extract has the potential to act as an immunomodulatory agent by regulating the immune response through the reduction of pro-inflammatory cytokines such as IFN-?+ and TNF-a+. This mechanism ultimately decreases inflammation and improves the liver condition of mice infected with Salmonella typhi.
Cite this article:
Maria Magdalena Riyaniarti Estri Wuryandari, Ninis Yuliati, Vivien Dwi Purnamasari. Red Moringa oleifera Demonstrates Protective Hepatotoxicy effects in Mice Infected with Salmonella typhi by Suppressing Natural Killer (NK) and Macrophage. Research Journal Pharmacy and Technology. 2025;18(11):5557-2. doi: 10.52711/0974-360X.2025.00801
Cite(Electronic):
Maria Magdalena Riyaniarti Estri Wuryandari, Ninis Yuliati, Vivien Dwi Purnamasari. Red Moringa oleifera Demonstrates Protective Hepatotoxicy effects in Mice Infected with Salmonella typhi by Suppressing Natural Killer (NK) and Macrophage. Research Journal Pharmacy and Technology. 2025;18(11):5557-2. doi: 10.52711/0974-360X.2025.00801 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2025-18-11-63
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