Author(s):
David Tjahyadi, Edy Parwanto, Hosea Jaya Edy, Joey Joshua Vidova Tjahyadi, Laurentia Gabrielle, Ashaolu Victoria Oladimeji, Seçil Karahüseyin
Email(s):
davesaboch@trisakti.ac.id
DOI:
10.52711/0974-360X.2025.00745 
Address:
David Tjahyadi1*, Edy Parwanto 2, Hosea Jaya Edy3, Joey Joshua Vidova Tjahyadi4, Laurentia Gabrielle4, Ashaolu Victoria Oladimeji5, Seçil Karahüseyin6
1Department of Histology, Faculty of Medicine, Universitas Trisakti, Indonesia.
2Department of Biology, Faculty of Medicine, Universitas Trisakti, Indonesia.
3Study Program of Pharmacy, Faculty of Math and Natural Sciences, Universitas Sam Ratulangi, Indonesia.
4Medical Education Program, Faculty of Medicine, Universitas Trisakti, Indonesia.
5Department of Chemistry, Loyola Institute of Frontier Energy, Loyola College, Chennai, India.
6Department of Pharmacognosy, Faculty of Pharmacy, Çukurova Universitesi, Turkey.
*Corresponding Author
Published In:
Volume - 18,
Issue - 11,
Year - 2025
ABSTRACT:
Lantana camara Linn. has potential as an anti-bacterial. The results of our preliminary research show that changes in levels of quercetin, gallic acid, and tannin affect the antibacterial effectiveness of E. coli, S. aureus, and P aeruginosa. In addition, changes in the levels of Fe, Zn, quercetin, gallic acid and tannin in the preparations mentioned above are caused by free radicals. Free radicals can be counteracted with antioxidants, for example ascorbic acid. The aim of this research is to determine the effect of adding 10% or 15% ascorbic acid to the L. camara Linn. leaf extract cream preparation on antioxidant activity. Apart from that, we also carry out cream standardization and irritation tests. In this study there were 6 groups of cream, namely cream 1 to cream 6. Cream 1 is the cream containing 4% LELC. Cream 2 is the cream containing 4% LELC+10% ASC AC. Cream 3 is the cream containing 4% LELC+15% ASC AC. Cream 4 is the cream containing 5% LELC. Cream 5 is the cream containing 5% LELC +10% ASC AC. Cream 6 is the cream containing 5% LELC+15% ASC AC. Organoleptic test results of cream in these studies shows a semi-solid form, has a characteristic odor of LELC, blackish green color, pH around 5, homogeneous, spread ability ranges from 3.8 – 3.9cm. IC50 of cream containing 5% LELC+15% ASC AC=2.64ppm. Cream containing 5% LELC+15% ASC AC contains flavonoids, phenolics, and tannins of 0.637±0.018mg/g; 0.487±0.005mg/g; and 0.83±0.06 mg/g, respectively. During the observation, no erythema or edema was found due to exposure to cream containing 5% LELC+15% ASC AC. As a control, the cream base also did not irritate the skin. Thus, the cream containing 5% LELC was proven to be non-irritating to the skin.
Cite this article:
David Tjahyadi, Edy Parwanto, Hosea Jaya Edy, Joey Joshua Vidova Tjahyadi, Laurentia Gabrielle, Ashaolu Victoria Oladimeji, Seçil Karahüseyin. Cream of Lantana camara Linn. Enriched with Ascorbic Acid does not Irritate the Skin. Research Journal Pharmacy and Technology. 2025;18(11):5161-9. doi: 10.52711/0974-360X.2025.00745
Cite(Electronic):
David Tjahyadi, Edy Parwanto, Hosea Jaya Edy, Joey Joshua Vidova Tjahyadi, Laurentia Gabrielle, Ashaolu Victoria Oladimeji, Seçil Karahüseyin. Cream of Lantana camara Linn. Enriched with Ascorbic Acid does not Irritate the Skin. Research Journal Pharmacy and Technology. 2025;18(11):5161-9. doi: 10.52711/0974-360X.2025.00745 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2025-18-11-7
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